{"id":"https://openalex.org/W2409792149","doi":null,"title":"beta-Sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle.","display_name":"beta-Sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2409792149","mag":"2409792149","pmid":"https://pubmed.ncbi.nlm.nih.gov/9568122"},"language":"en","primary_location":{"id":"pmid:9568122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016850242","display_name":"Atif B. Awad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A B Awad","raw_affiliation_strings":["Department of Physical Therapy, Exercise and Nutrition Sciences, SUNY/Buffalo, NY 14214, USA. awad@acsu.buffalo.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, Exercise and Nutrition Sciences, SUNY/Buffalo, NY 14214, USA. awad@acsu.buffalo.edu","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112148259","display_name":"Rebecca L. von Holtz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L von Holtz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025503623","display_name":"J P Cone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Cone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037617915","display_name":"Carol S. Fink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Fink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070755803","display_name":"Y C Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y C Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6471,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.83984932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"1A","first_page":"471","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sphingomyelin-cycle","display_name":"sphingomyelin cycle","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ceramide-production","display_name":"ceramide production","score":0.8109999895095825},{"id":"https://openalex.org/keywords/sphingosine","display_name":"sphingosine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7540000081062317},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9369999766349792},{"id":"https://openalex.org/keywords/protein-kinase-c-pathway","display_name":"protein kinase C pathway","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.7699050307273865},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7146867513656616},{"id":"https://openalex.org/C2779718769","wikidata":"https://www.wikidata.org/wiki/Q412457","display_name":"Phytosterol","level":2,"score":0.6988818645477295},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6436952948570251},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6223800182342529},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.5996497273445129},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5991150140762329},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5936734676361084},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.5397016406059265},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.517115592956543},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.4904603660106659},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.465353786945343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41416236758232117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37817108631134033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3044753074645996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19125422835350037},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07375341653823853},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012855","descriptor_name":"Sitosterols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9568122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2409792149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W32400621","https://openalex.org/W2368048764","https://openalex.org/W1996784811","https://openalex.org/W1997701398","https://openalex.org/W2383887515","https://openalex.org/W2056972390","https://openalex.org/W2416853832","https://openalex.org/W2016776899","https://openalex.org/W1515302524","https://openalex.org/W1515558138"],"abstract_inverted_index":{"The":[0],"present":[1],"study":[2],"examined":[3],"the":[4,12,23,27,39,80,86,89],"SM":[5,90],"cycle":[6,91],"as":[7,45,64],"a":[8,76,94],"mechanism":[9],"to":[10,47,66],"explain":[11],"inhibitory":[13],"effect":[14,53,72],"of":[15,30,88,99],"SIT":[16,21,31,49,62],"on":[17,54,73],"HT-29":[18,100],"cell":[19],"growth.":[20],"was":[22],"main":[24],"phytosterol":[25],"in":[26,38,79,96],"diet.":[28],"Supplementation":[29],"at":[32],"16":[33],"microM":[34],"for":[35],"5":[36],"days":[37],"media":[40],"inhibited":[41],"growth":[42,97],"by":[43,102],"55%":[44],"compared":[46,65],"cholesterol.":[48,67],"supplementation":[50,63,69],"had":[51,70],"no":[52,71],"sphingosine":[55],"production.":[56],"Ceramide":[57],"production":[58],"increased":[59],"45%":[60],"with":[61],"Sterol":[68],"phospholipase":[74],"C,":[75],"key":[77],"enzyme":[78],"PKC":[81],"pathway.":[82],"We":[83],"concluded":[84],"that":[85],"activation":[87],"may":[92],"play":[93],"role":[95],"inhibition":[98],"cells":[101],"SIT.":[103]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
