{"id":"https://openalex.org/W2409753545","doi":"https://doi.org/10.1093/ajh/4.9.735","title":"Plasma Renin Activity and Norepinephrine as Predictors for Antihypertensive Effects of Nifedipine and Captopril","display_name":"Plasma Renin Activity and Norepinephrine as Predictors for Antihypertensive Effects of Nifedipine and Captopril","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W2409753545","doi":"https://doi.org/10.1093/ajh/4.9.735","mag":"2409753545","pmid":"https://pubmed.ncbi.nlm.nih.gov/1930858"},"language":"en","primary_location":{"id":"doi:10.1093/ajh/4.9.735","doi":"https://doi.org/10.1093/ajh/4.9.735","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/4.9.735","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070364832","display_name":"Miho Kusaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405284155","display_name":"Saiseikai Hiroshima Hospital","ror":"https://ror.org/031ts9w93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284155"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Miho Kusaka","raw_affiliation_strings":["Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026210593","display_name":"Keiichiro Atarashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405284155","display_name":"Saiseikai Hiroshima Hospital","ror":"https://ror.org/031ts9w93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichiro Atarashi","raw_affiliation_strings":["Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105194224","display_name":"Koji Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405284155","display_name":"Saiseikai Hiroshima Hospital","ror":"https://ror.org/031ts9w93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Matsumoto","raw_affiliation_strings":["Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041963986","display_name":"Yukinobu Sumida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405284155","display_name":"Saiseikai Hiroshima Hospital","ror":"https://ror.org/031ts9w93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukinobu Sumida","raw_affiliation_strings":["Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043663301","display_name":"Hideo Matsuura","orcid":"https://orcid.org/0000-0002-0907-2153","observed_orcids":["https://orcid.org/0000-0002-0907-2153"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405284155","display_name":"Saiseikai Hiroshima Hospital","ror":"https://ror.org/031ts9w93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Matsuura","raw_affiliation_strings":["Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101340","display_name":"Tetsuji Shingu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405284155","display_name":"Saiseikai Hiroshima Hospital","ror":"https://ror.org/031ts9w93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuji Shingu","raw_affiliation_strings":["Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072691675","display_name":"Goto Kajiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]},{"id":"https://openalex.org/I4405284155","display_name":"Saiseikai Hiroshima Hospital","ror":"https://ror.org/031ts9w93","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Goto Kajiyama","raw_affiliation_strings":["Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saiseikai Hiroshima Hospital, 1st Department of Internal Medicine, Hiroshima University, Japan","institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070364832"],"corresponding_institution_ids":["https://openalex.org/I113306721","https://openalex.org/I4405284155"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":0.707,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68557308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"9","first_page":"735","last_page":"739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.2451000064611435,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/captopril","display_name":"captopril","score":1.0},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antihypertensive-efficacy","display_name":"antihypertensive efficacy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6019999980926514},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.7820000052452087},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.972000002861023},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8769999742507935},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.967795193195343},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.9287500977516174},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.808862566947937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7848422527313232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.707459568977356},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6597128510475159},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.6194939613342285},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6163305044174194},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.6139445304870605},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.5891193151473999},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.45733198523521423},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.29925018548965454},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.05637425184249878},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.048901379108428955}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajh/4.9.735","doi":"https://doi.org/10.1093/ajh/4.9.735","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/4.9.735","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:1930858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1930858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7038061744","https://openalex.org/W2324113071","https://openalex.org/W1987533286","https://openalex.org/W2164701299","https://openalex.org/W2016606639","https://openalex.org/W1965094135","https://openalex.org/W2082318070","https://openalex.org/W2400589292","https://openalex.org/W2042490342","https://openalex.org/W2314497937"],"abstract_inverted_index":{"To":[0],"examine":[1],"predictors":[2],"for":[3,47,124],"the":[4,11,90,222],"efficacy":[5],"of":[6,13,80,92,128,136,226],"antihypertensive":[7,218],"agents,":[8],"we":[9],"investigated":[10],"effects":[12],"nifedipine":[14,41,95,137,213,227],"and":[15,21,50,77,83,88,96,154,164,193,214,220],"captopril":[16,60,97,206,215,238],"on":[17,142],"blood":[18],"pressure":[19,67],"(BP)":[20],"humoral":[22,143],"factors":[23],"in":[24,174,190,205,231,242],"patients":[25,32,192],"with":[26,38,59,180,195,234,244],"essential":[27,30,52,232],"hypertension.":[28],"Eleven":[29],"hypertensive":[31],"(mean":[33,54],"age:":[34,55],"54)":[35],"were":[36,57,85,216],"treated":[37,58],"long":[39,223],"acting":[40],"at":[42,61,89],"20":[43],"to":[44,63,106,116],"40":[45],"mg/day":[46],"8":[48],"weeks":[49],"25":[51],"hypertensives":[53,233],"51)":[56],"37.5":[62],"75":[64],"mg/day.":[65],"Blood":[66],"was":[68,177],"measured":[69],"every":[70],"2":[71,109,115],"weeks.":[72],"Plasma":[73],"renin":[74],"activity":[75],"(PRA),":[76],"plasma":[78,156,246],"concentrations":[79],"aldosterone,":[81],"epinephrine":[82,157],"norepinephrine":[84,165,197,247],"determined":[86],"before":[87],"end":[91],"treatment.":[93,207],"Both":[94],"decreased":[98,155],"BP":[99,102,176],"(nifedipine:":[100],"mean":[101,175],"119":[103],"+/-":[104,108,114,118],"3":[105],"101":[107],"mm":[110],"Hg,":[111],"captopril:":[112],"124":[113],"100":[117],"2,":[119],"P":[120,186,201],"less":[121,151,161,169,187,202],"than":[122,152,162,170,188,203],".01":[123],"each),":[125],"whereas":[126],"neither":[127],"them":[129],"affected":[130],"heart":[131],"rate.":[132],"The":[133,172,208],"8-week":[134],"treatment":[135,225],"showed":[138],"no":[139],"significant":[140],"effect":[141],"factors.":[144],"Captopril":[145],"increased":[146],"PRA":[147,182],"by":[148,158,166],"63%":[149],"(P":[150,160,168],".05)":[153],"42%":[159],".01)":[163,189,204],"35%":[167],".01).":[171],"change":[173],"positively":[178],"correlated":[179],"pretreatment":[181,196],"(r":[183,198],"=":[184,199],"0.68,":[185],"nifedipine-treated":[191],"inversely":[194],"-0.53,":[200],"results":[209],"suggest":[210],"that":[211,221],"both":[212],"effective":[217,230,241],"agents":[219],"term":[224],"is":[228,239],"more":[229,240],"lower":[235],"PRA,":[236],"while":[237],"those":[243],"higher":[245],"concentration.":[248]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}