{"id":"https://openalex.org/W2409705697","doi":"https://doi.org/10.1016/j.jalz.2015.06.1787","title":"P4\u2010082: Hippocampal mean diffusivity is a biomarker of neuronal injury in patients with mild cognitive impairment and Alzheimer's disease dementia","display_name":"P4\u2010082: Hippocampal mean diffusivity is a biomarker of neuronal injury in patients with mild cognitive impairment and Alzheimer's disease dementia","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W2409705697","doi":"https://doi.org/10.1016/j.jalz.2015.06.1787","mag":"2409705697"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2015.06.1787","doi":"https://doi.org/10.1016/j.jalz.2015.06.1787","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.06.1787","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045956136","display_name":"Ignacio Demey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ignacio Demey","raw_affiliation_strings":["INEBA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INEBA, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035781007","display_name":"Fernando Ventrice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Ventrice","raw_affiliation_strings":["INEBA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INEBA, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080524982","display_name":"Galeno Jes\u00fas Rojas","orcid":"https://orcid.org/0000-0002-3912-9421","observed_orcids":["https://orcid.org/0000-0002-3912-9421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Galeno Rojas","raw_affiliation_strings":["INEBA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INEBA, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066984112","display_name":"Ricardo Allegri","orcid":"https://orcid.org/0000-0001-7166-1234","observed_orcids":["https://orcid.org/0000-0001-7166-1234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allegri Ricardo","raw_affiliation_strings":["INEBA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INEBA, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110242153","display_name":"Ver\u00f3nica Somale","orcid":"https://orcid.org/0000-0001-9072-2792","observed_orcids":["https://orcid.org/0000-0001-9072-2792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica Somale","raw_affiliation_strings":["INEBA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INEBA, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024679142","display_name":"Victoria Zubiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Zubiri","raw_affiliation_strings":["INEBA, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INEBA, Buenos Aires, Argentina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045956136"],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.2253,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56390146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"7S_Part_17","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.7205230593681335},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6476957201957703},{"id":"https://openalex.org/C2778048536","wikidata":"https://www.wikidata.org/wiki/Q1545429","display_name":"Parahippocampal gyrus","level":4,"score":0.5857855677604675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5515753626823425},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5512233972549438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5319179892539978},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4873405396938324},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4872678518295288},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.48578670620918274},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4398082196712494},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4394795298576355},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4127892851829529},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3594781160354614},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31911954283714294},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.316593736410141},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.1787925362586975},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1356903314590454},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2015.06.1787","doi":"https://doi.org/10.1016/j.jalz.2015.06.1787","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.06.1787","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2262584144","https://openalex.org/W2568315036","https://openalex.org/W2128776571","https://openalex.org/W2092993734","https://openalex.org/W2162192631","https://openalex.org/W2161266529","https://openalex.org/W1632809898","https://openalex.org/W2028395540","https://openalex.org/W2045333811","https://openalex.org/W2067735194"],"abstract_inverted_index":{"Different":[0],"areas":[1,47,236,258],"of":[2,25,39,48,104,115,156],"the":[3,23,37,49,100,107,113,116,118,123,140,154,170,185,209,212,228,234,262,267,273,285],"medial":[4,50],"temporal":[5,51],"cortex":[6],"are":[7],"usually":[8],"involved":[9],"in":[10,16,54,58,99,248],"Alzheimer's":[11,68],"Disease":[12,69],"(AD).":[13],"Mean":[14],"Diffusivity":[15],"Magnetic":[17],"Resonance":[18],"Imaging":[19],"(MD-MRI)":[20],"measurements":[21,152],"enable":[22],"analysis":[24],"water":[26],"movements":[27],"at":[28,46,112,139,184,211,256,284],"tissue":[29],"level,":[30],"and":[31,57,67,85,94,122,173,192,201,221,245,251],"increased":[32],"diffusivity":[33],"is":[34],"associated":[35],"with":[36,60,83,88,127,136,146,165,169,175,177],"presence":[38],"microstructure":[40,269],"damages.":[41],"Objective:":[42],"To":[43],"analyze":[44],"MD-MRI":[45,105,149,243,255],"cortex,":[52],"both":[53],"healthy":[55,78],"controls":[56,200],"patients":[59,82,87,167,174,190],"degenerative":[61],"amnesic":[62],"Mild":[63],"Cognitive":[64],"Impairment":[65],"(aMCI)":[66],"Dementia":[70],"(ADD).":[71],"Forty-eight":[72],"individuals":[73],"(age":[74],"74.71\u00b17.18":[75],"years)":[76],"[16":[77],"control":[79],"individuals,":[80],"15":[81],"aMCI,":[84],"17":[86],"ADD],":[89],"right-handed,":[90],"paired":[91],"by":[92,281],"age":[93],"education":[95],"level":[96,114],"were":[97,110,134,182,205,278],"included":[98],"study.":[101],"The":[102],"findings":[103,133,277],"among":[106,208,261],"different":[108],"groups":[109,158,210,230],"analyzed":[111],"hippocampus,":[117],"Parahippocampal":[119],"Gyrus":[120],"(PG),":[121],"Entorhinal":[124],"Cortex":[125],"(EC)":[126],"ANOVA":[128],"(post-hoc":[129],"Bonferroni":[130],"test).":[131],"These":[132,276],"correlated":[135],"their":[137],"performance":[138,247,283],"California":[141],"Verbal":[142],"Learning":[143],"Test":[144],"(CVLT),":[145],"Pearson":[147],"test.":[148],"right":[150,222],"hippocampus":[151,187],"enabled":[153],"identification":[155],"3":[157,229,263],"(ADD-controls:":[159,215,219,224],"p<0.001,":[160],"ADD-aMCI:":[161],"p<0,05,":[162],"aMCI-controls:":[163],"p<0.05),":[164,216,220],"ADD":[166],"presenting":[168],"highest":[171],"values,":[172],"aMCI":[176,202],"intermediate":[178],"results.":[179],"Significant":[180],"differences":[181,197,260],"noted":[183,198,207],"left":[186,213,217],"between":[188,199,242],"ADD-aMCI":[189],"(p<0.01)":[191],"ADD-controls":[193],"(p<0.001),":[194],"without":[195],"significant":[196,239],"patients.":[203],"Differences":[204],"also":[206,279],"PG":[214],"EC":[218,223],"p<0.01).":[225],"When":[226],"analyzing":[227],"as":[231],"a":[232],"whole,":[233],"6":[235],"assessed":[237],"showed":[238],"negative":[240],"correlations":[241],"values":[244],"patient":[246],"CVLT":[249],"coding":[250],"delay":[252],"recall":[253],"tests.":[254],"these":[257,291],"revealed":[259],"groups,":[264],"thus":[265],"reflecting":[266],"progressive":[268],"damage":[270],"present":[271],"throughout":[272],"AD":[274],"spectrum.":[275],"evidenced":[280],"patients'":[282],"episodic":[286],"memory":[287],"tests":[288],"based":[289],"on":[290],"structures.":[292]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
