{"id":"https://openalex.org/W2409657284","doi":"https://doi.org/10.1152/ajpgi.1984.247.5.g567","title":"Autonomic regulation of somatostatin release: studies with primary cultures of canine fundic mucosal cells","display_name":"Autonomic regulation of somatostatin release: studies with primary cultures of canine fundic mucosal cells","publication_year":1984,"publication_date":"1984-11-01","ids":{"openalex":"https://openalex.org/W2409657284","doi":"https://doi.org/10.1152/ajpgi.1984.247.5.g567","mag":"2409657284","pmid":"https://pubmed.ncbi.nlm.nih.gov/6149698"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1984.247.5.g567","doi":"https://doi.org/10.1152/ajpgi.1984.247.5.g567","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1984.247.5.g567","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058981662","display_name":"Tadataka Yamada","orcid":"https://orcid.org/0000-0001-8031-4023","observed_orcids":["https://orcid.org/0000-0001-8031-4023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Yamada","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083325211","display_name":"Andrew H. Soll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. H. Soll","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076040986","display_name":"J. Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Park","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002463388","display_name":"JANET DIXON ELASHOFF","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Elashoff","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.26,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.77169647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"247","issue":"5","first_page":"G567","last_page":"G573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7143999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.16769999265670776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/somatostatin-like-immunoreactivity","display_name":"somatostatin-like immunoreactivity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fundic-mucosa","display_name":"fundic mucosa","score":0.8059999942779541},{"id":"https://openalex.org/keywords/parietal-cells","display_name":"parietal cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/autonomic-regulation","display_name":"autonomic regulation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/gastrin","display_name":"gastrin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.949999988079071},{"id":"https://openalex.org/keywords/cholinergic-modulation","display_name":"cholinergic modulation","score":0.578000009059906},{"id":"https://openalex.org/keywords/adrenergic-regulation","display_name":"adrenergic regulation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.8029999732971191},{"id":"https://openalex.org/keywords/phentolamine","display_name":"phentolamine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pirenzepine","display_name":"pirenzepine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.7839999794960022},{"id":"https://openalex.org/keywords/methoxamine","display_name":"methoxamine","score":0.6899999976158142},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.843999981880188},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.6169999837875366},{"id":"https://openalex.org/keywords/primary-culture","display_name":"primary cell culture","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8611863851547241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8507118225097656},{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.8348613977432251},{"id":"https://openalex.org/C2780745239","wikidata":"https://www.wikidata.org/wiki/Q685119","display_name":"Methoxamine","level":4,"score":0.8251268863677979},{"id":"https://openalex.org/C2780253649","wikidata":"https://www.wikidata.org/wiki/Q420360","display_name":"Phentolamine","level":3,"score":0.5126830339431763},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5105867981910706},{"id":"https://openalex.org/C2780648677","wikidata":"https://www.wikidata.org/wiki/Q425296","display_name":"Prazosin","level":4,"score":0.5037538409233093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5013294219970703},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.48543959856033325},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.45239678025245667},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.428394079208374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3302062451839447},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3283706307411194},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2587360441684723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17754977941513062}],"mesh":[{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1984.247.5.g567","doi":"https://doi.org/10.1152/ajpgi.1984.247.5.g567","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1984.247.5.g567","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:6149698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6149698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413382917","https://openalex.org/W1972916223","https://openalex.org/W2429942289","https://openalex.org/W2414195060","https://openalex.org/W2134275599","https://openalex.org/W1973600365","https://openalex.org/W2061617031","https://openalex.org/W2059635804","https://openalex.org/W2144953427","https://openalex.org/W2052045221"],"abstract_inverted_index":{"Using":[0],"a":[1,57,73,162],"newly":[2],"developed":[3],"system":[4],"for":[5,43],"culturing":[6],"canine":[7,27,194],"fundic":[8,28,195],"mucosal":[9],"cells,":[10],"we":[11],"examined":[12],"regulation":[13],"of":[14,17,77,140,166,180],"the":[15,64,78,83,111,118,129,132,138,167,178,193],"secretion":[16,55,102,152],"somatostatinlike":[18],"immunoreactivity":[19],"(SLI)":[20],"by":[21,36,92,110,117,154],"cholinergic":[22],"and":[23,39,48,157,201],"adrenergic":[24,134,142],"transmitters.":[25],"Enzyme-dispersed":[26],"mucosa":[29,196],"cells":[30,191],"were":[31],"enriched":[32],"in":[33,49,56,103,192],"SLI":[34,54,101,151],"content":[35],"counterflow":[37],"elutriation":[38],"cultured":[40],"on":[41],"collagen":[42],"42":[44],"h.":[45],"Epinephrine":[46],"alone,":[47],"combination":[50],"with":[51,82],"gastrin,":[52,155],"stimulated":[53,153],"dose-dependent":[58],"fashion.":[59],"Propranolol":[60],"did":[61],"not":[62,116],"alter":[63],"response":[65,104,130],"to":[66,88,105,131],"dibutyryl":[67,158],"cAMP":[68],"or":[69],"gastrin":[70],"but":[71,115],"produced":[72,161],"parallel,":[74],"rightward":[75,164],"shift":[76,165],"epinephrine":[79],"dose-response":[80,169],"curve":[81,94,170],"dissociation":[84],"constant":[85],"(Ki)":[86],"determined":[87],"be":[89],"14":[90],"nM":[91],"nonlinear":[93],"fitting.":[95],"Phentolamine,":[96],"an":[97,107,141],"alpha-adrenergic":[98],"antagonist,":[99],"enhanced":[100],"epinephrine,":[106,156],"effect":[108],"reversed":[109],"alpha":[112,119,143],"1-agonist":[113],"methoxamine":[114,124],"2-agonist":[120],"clonidine.":[121],"However,":[122],"neither":[123],"nor":[125],"clonidine":[126],"alone":[127],"inhibited":[128,150,177],"beta-selective":[133],"agonist":[135],"isoproterenol;":[136],"thus,":[137],"existence":[139],"1-inhibitory":[144],"receptor":[145],"remained":[146],"uncertain.":[147],"Carbachol":[148],"noncompetitively":[149],"cAMP.":[159],"Atropine":[160],"parallel":[163],"carbachol":[168,181],"(Ki":[171,182],"=":[172,183],"0.4":[173],"nM).":[174,185],"Pirenzepine":[175],"also":[176],"effects":[179],"35":[184],"Our":[186],"studies":[187],"suggest":[188],"that":[189],"SLI-containing":[190],"possess":[197],"stimulatory":[198],"beta-adrenergic":[199],"receptors":[200],"inhibitory":[202],"muscarinic":[203],"receptors.":[204]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}