{"id":"https://openalex.org/W2409648774","doi":null,"title":"Prolonged treatment with acrivastine for seasonal allergic rhinitis.","display_name":"Prolonged treatment with acrivastine for seasonal allergic rhinitis.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2409648774","mag":"2409648774","pmid":"https://pubmed.ncbi.nlm.nih.gov/2570001"},"language":"en","primary_location":{"id":"pmid:2570001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2570001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of international medical research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G Bruno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Bruno","raw_affiliation_strings":["First Department of Clinical Medicine, Policlinico Umberto I, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Clinical Medicine, Policlinico Umberto I, Rome, Italy","institution_ids":["https://openalex.org/I2800330116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059081126","display_name":"Gennaro D\u2019Amato","orcid":"https://orcid.org/0000-0002-0503-9428","observed_orcids":["https://orcid.org/0000-0002-0503-9428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D'Amato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015853031","display_name":"Gennaro Sergio Del Giacco","orcid":"https://orcid.org/0000-0001-9169-9440","observed_orcids":["https://orcid.org/0000-0001-9169-9440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Del Giacco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091836347","display_name":"Francesca Locci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Locci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047759290","display_name":"Gale Nm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N M Gale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086680967","display_name":"E Errigo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Errigo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112728407","display_name":"G Melillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Melillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1803,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.54918494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17 Suppl 2","issue":null,"first_page":"40B","last_page":"46B"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acrivastine","display_name":"acrivastine","score":1.0},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.9559999704360962},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.8370000123977661},{"id":"https://openalex.org/keywords/symptom-management","display_name":"symptom management","score":0.9589999914169312},{"id":"https://openalex.org/keywords/adverse-experiences","display_name":"adverse experiences","score":0.48899999260902405},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7139999866485596},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8890557289123535},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8571350574493408},{"id":"https://openalex.org/C2776880894","wikidata":"https://www.wikidata.org/wiki/Q324089","display_name":"Antihistamine","level":2,"score":0.7142922282218933},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.6999208331108093},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.5699503421783447},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5606614351272583},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5540979504585266},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45437946915626526},{"id":"https://openalex.org/C2776989088","wikidata":"https://www.wikidata.org/wiki/Q16364","display_name":"Throat","level":2,"score":0.4114556312561035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34080350399017334},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27674514055252075},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014311","descriptor_name":"Triprolidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014311","descriptor_name":"Triprolidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2570001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2570001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of international medical research","raw_type":"Clinical Trial"},{"id":"mag:2409648774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2570001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2335872315","https://openalex.org/W2419639319","https://openalex.org/W2413913008","https://openalex.org/W2182163202","https://openalex.org/W2419712681","https://openalex.org/W2080008296","https://openalex.org/W1984249906","https://openalex.org/W3043842238","https://openalex.org/W2128180999","https://openalex.org/W1977910080"],"abstract_inverted_index":{"In":[0],"a":[1],"double-blind,":[2],"placebo-controlled":[3],"multicentre":[4],"study,":[5],"the":[6,15,22,42,65,76,88,94,100,142,148,168],"antihistamine":[7],"acrivastine,":[8],"was":[9,35,61,84],"used":[10],"over":[11,160],"prolonged":[12,161],"periods":[13,162],"for":[14,128,167],"treatment":[16,24,73,124,152,169],"of":[17,26,44,91,105,144,150,170],"seasonal":[18,171],"allergic":[19,172],"rhinitis.":[20,173],"After":[21],"initial":[23],"period":[25],"10":[27],"days,":[28],"8":[29],"mg":[30],"acrivastine":[31,60,113,138],"three":[32,130],"times":[33],"daily":[34],"significantly":[36],"superior":[37],"to":[38,87,103,114,119,164],"placebo":[39,95,123,140],"in":[40,64,93,117,141],"controlling":[41],"symptoms":[43],"sneezing,":[45],"itchy":[46,52,55],"nose,":[47,49],"running":[48],"watery":[50],"eyes,":[51],"eyes":[53],"and":[54,69,139,157],"throat.":[56],"The":[57,107],"benefit":[58],"from":[59,99],"also":[62],"apparent":[63],"second":[66],"(14":[67],"days)":[68,72,166],"third":[70],"(28":[71],"periods,":[74],"although":[75],"difference":[77],"no":[78,134],"longer":[79],"reached":[80],"statistical":[81],"significance.":[82],"This":[83],"probably":[85],"due":[86],"large":[89],"proportion":[90],"non-responders":[92],"group":[96],"who":[97],"withdrew":[98],"study":[101],"owing":[102],"lack":[104],"efficacy.":[106],"investigators":[108],"rated":[109],"symptom":[110],"control":[111,121],"with":[112,122],"be":[115],"'good'":[116],"comparison":[118],"'poor'":[120],"(P":[125],"=":[126],"0.01)":[127],"all":[129],"periods.":[131],"There":[132],"were":[133],"significant":[135],"differences":[136],"between":[137],"incidence":[143],"adverse":[145],"experiences":[146],"at":[147],"end":[149],"each":[151],"period.":[153],"Acrivastine":[154],"is":[155],"effective":[156],"well":[158],"tolerated":[159],"(up":[163],"52":[165]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}