{"id":"https://openalex.org/W2409645804","doi":"https://doi.org/10.1387/ijdb.8877443","title":"Morphogenesis of the axolotl pronephric duct: a model system for the study of cell migration in vivo","display_name":"Morphogenesis of the axolotl pronephric duct: a model system for the study of cell migration in vivo","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2409645804","doi":"https://doi.org/10.1387/ijdb.8877443","mag":"2409645804","pmid":"https://pubmed.ncbi.nlm.nih.gov/8877443"},"language":"en","primary_location":{"id":"doi:10.1387/ijdb.8877443","doi":"https://doi.org/10.1387/ijdb.8877443","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.8877443","pdf_url":"https://ijdb.ehu.eus/article/pdf/8877443","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ijdb.ehu.eus/article/pdf/8877443","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060387069","display_name":"Julie Drawbridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Drawbridge","raw_affiliation_strings":["Department of Molecular Biology , Princeton University , Princeton , New Jersey , USA","Department of Molecular Biology, Princeton University, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology , Princeton University , Princeton , New Jersey , USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, New Jersey, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103512422","display_name":"Malcolm S. Steinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Steinberg","raw_affiliation_strings":["Department of Molecular Biology , Princeton University , Princeton , New Jersey , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology , Princeton University , Princeton , New Jersey , USA","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":null,"apc_paid":null,"fwci":0.2378,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.50374632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"40","issue":"4","first_page":"709","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.4666000008583069,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pronephric-duct","display_name":"pronephric duct","score":0.8709999918937683},{"id":"https://openalex.org/keywords/morphogenesis","display_name":"morphogenesis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/axolotl","display_name":"axolotl","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ureteric-bud","display_name":"ureteric bud","score":0.7699999809265137},{"id":"https://openalex.org/keywords/metanephros","display_name":"metanephros","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mesonephros","display_name":"mesonephros","score":0.7870000004768372},{"id":"https://openalex.org/keywords/vas-deferens","display_name":"vas deferens","score":0.765999972820282},{"id":"https://openalex.org/keywords/somites","display_name":"somites","score":0.5640000104904175},{"id":"https://openalex.org/keywords/mesoderm","display_name":"mesoderm","score":0.6399999856948853},{"id":"https://openalex.org/keywords/environmental-cues","display_name":"environmental cues","score":0.6330000162124634},{"id":"https://openalex.org/keywords/cell-surface-recognition","display_name":"cell surface recognition","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9220122694969177},{"id":"https://openalex.org/C85380620","wikidata":"https://www.wikidata.org/wiki/Q583232","display_name":"Mesonephric duct","level":3,"score":0.8779181838035583},{"id":"https://openalex.org/C184750944","wikidata":"https://www.wikidata.org/wiki/Q557677","display_name":"Primordium","level":3,"score":0.7151108980178833},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.6970646381378174},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.6691074967384338},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6438435912132263},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.5879525542259216},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5811893343925476},{"id":"https://openalex.org/C31697123","wikidata":"https://www.wikidata.org/wiki/Q2656768","display_name":"Pronephros","level":4,"score":0.5792149305343628},{"id":"https://openalex.org/C182928434","wikidata":"https://www.wikidata.org/wiki/Q6047369","display_name":"Intermediate mesoderm","level":5,"score":0.5157935619354248},{"id":"https://openalex.org/C130010870","wikidata":"https://www.wikidata.org/wiki/Q2500532","display_name":"Ureteric bud","level":5,"score":0.5135898590087891},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5008845329284668},{"id":"https://openalex.org/C43768951","wikidata":"https://www.wikidata.org/wiki/Q1468875","display_name":"Mesonephros","level":4,"score":0.4467528164386749},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4419460594654083},{"id":"https://openalex.org/C78214289","wikidata":"https://www.wikidata.org/wiki/Q882043","display_name":"Blastema","level":3,"score":0.4399249851703644},{"id":"https://openalex.org/C2779945282","wikidata":"https://www.wikidata.org/wiki/Q22718","display_name":"Axolotl","level":3,"score":0.4143815040588379},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.30176717042922974},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2958611249923706},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.22179579734802246},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19870781898498535},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.19424253702163696},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.1119081974029541},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.10187387466430664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09887123107910156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08498430252075195},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000557","descriptor_name":"Ambystoma","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014649","descriptor_name":"Vas Deferens","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1387/ijdb.8877443","doi":"https://doi.org/10.1387/ijdb.8877443","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.8877443","pdf_url":"https://ijdb.ehu.eus/article/pdf/8877443","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},{"id":"pmid:8877443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8877443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of developmental biology","raw_type":"Journal Article"},{"id":"mag:2409645804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8877443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1387/ijdb.8877443","doi":"https://doi.org/10.1387/ijdb.8877443","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.8877443","pdf_url":"https://ijdb.ehu.eus/article/pdf/8877443","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3978670374","display_name":"ENGINEERING CELL ADHESION FOR ORGAN DESIGN","funder_award_id":"5r01hd030345-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6748498965","display_name":"MOLECULAR BASIS OF PRONEPHRIC DUCT CELL GUIDANCE","funder_award_id":"R01CA013605","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7273093464","display_name":"ALKALINE PHOSPHATASE'S ROLE IN VERTEBRATE MORPHOGENESIS","funder_award_id":"1f32hd007753-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2409645804.pdf","grobid_xml":"https://content.openalex.org/works/W2409645804.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038261092","https://openalex.org/W2134842638","https://openalex.org/W2425789064","https://openalex.org/W2050871222","https://openalex.org/W1965902071","https://openalex.org/W2402365432","https://openalex.org/W1995465266","https://openalex.org/W2124634308","https://openalex.org/W2473399032","https://openalex.org/W1983640735"],"abstract_inverted_index":{"Pronephric":[0],"duct":[1],"(PND)":[2],"morphogenesis":[3],"is":[4,19],"a":[5],"critical":[6],"early":[7],"event":[8],"in":[9,68,81,160,171],"the":[10,13,20,30,34,40,44,48,58,66,76,89,97,100,110,124,128,134,147,152,155,165,173,177],"development":[11],"of":[12,33,43,57,65,75,88,127,154],"vertebrate":[14],"excretory":[15],"system.":[16],"This":[17,162],"structure":[18],"exit":[21],"channel":[22],"for":[23,151],"both":[24],"pronephric":[25],"and":[26,36,50,60,85,176],"mesonephric":[27,59],"filtrate,":[28],"forms":[29],"ureteric":[31,51],"bud":[32,52],"metanephros":[35],"gives":[37],"rise":[38],"to":[39],"ductus":[41],"deferens":[42],"testis.":[45],"In":[46,78,96],"addition,":[47],"PND":[49,67,90,101,148],"epithelia":[53],"induce":[54],"terminal":[55],"differentiation":[56],"metanephric":[61],"mesenchyme,":[62],"respectively.":[63],"Elongation":[64],"all":[69],"vertebrates":[70],"involves":[71],"active":[72],"cell":[73,94,158,178],"migration":[74,159,187],"primordium.":[77],"urodele":[79],"embryos--unlike":[80],"some":[82],"anuran,":[83],"avian":[84],"mammalian":[86],"embryos--elongation":[87],"occurs":[91],"solely":[92],"by":[93],"migration.":[95],"axolotl":[98],"embryo,":[99],"primordium":[102,119],"segregates":[103],"as":[104],"an":[105],"ovoid":[106],"tissue":[107],"mass":[108],"from":[109],"anterodorsal":[111],"flank":[112],"mesoderm":[113],"directly":[114],"beneath":[115],"somites":[116,130],"3-7.":[117],"The":[118,136],"then":[120],"extends":[121],"caudally":[122],"along":[123],"ventral":[125],"border":[126],"developing":[129],"until":[131],"it":[132],"reaches":[133],"cloaca.":[135],"ease":[137],"with":[138],"which":[139],"these":[140],"embryos":[141],"can":[142],"be":[143],"manipulated":[144],"microsurgically":[145],"makes":[146],"system":[149],"ideal":[150],"study":[153],"mechanisms":[156],"controlling":[157],"vivo.":[161],"review":[163],"summarizes":[164],"progress":[166],"that":[167,182],"has":[168],"been":[169],"made":[170],"characterizing":[172],"environmental":[174],"cues":[175],"surface":[179],"recognition":[180],"systems":[181],"drive":[183],"this":[184],"tightly":[185],"regulated":[186],"event.":[188]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}