{"id":"https://openalex.org/W2409638947","doi":null,"title":"Iron and the liver.","display_name":"Iron and the liver.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2409638947","mag":"2409638947","pmid":"https://pubmed.ncbi.nlm.nih.gov/16462704"},"language":"en","primary_location":{"id":"pmid:16462704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16462704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/612286","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032998749","display_name":"Elena Corradini","orcid":"https://orcid.org/0000-0001-9477-2164","observed_orcids":["https://orcid.org/0000-0001-9477-2164"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Corradini","raw_affiliation_strings":["Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francesca Ferrara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Ferrara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047570187","display_name":"Antonello Pietrangelo","orcid":"https://orcid.org/0000-0002-7411-935X","observed_orcids":["https://orcid.org/0000-0002-7411-935X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonello Pietrangelo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6399,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71864198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2 Suppl 2","issue":null,"first_page":"245","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.7889999747276306},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9049999713897705},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hepcidin","display_name":"hepcidin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hemochromatosis","display_name":"hemochromatosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/iron-toxicity","display_name":"iron toxicity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.7409999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hepatocyte-injury","display_name":"hepatocyte injury","score":0.5429999828338623},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/kupffer-cells","display_name":"Kupffer cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metal-transporters","display_name":"metal transporters","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7699999809265137},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.6050000190734863},{"id":"https://openalex.org/keywords/chelation-therapy","display_name":"chelation therapy","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.6620082259178162},{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.614316463470459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5603365302085876},{"id":"https://openalex.org/C2775832776","wikidata":"https://www.wikidata.org/wiki/Q65122087","display_name":"Ferrous","level":2,"score":0.5071346759796143},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.48700886964797974},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48596417903900146},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.476176917552948},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.4653528332710266},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3896372616291046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3607100248336792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3220841884613037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30217164754867554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2372150719165802},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22534850239753723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20979169011116028},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064451","descriptor_name":"Hepcidins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16462704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16462704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/612286","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/612286","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2409638947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16462704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/612286","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/612286","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1989020470","https://openalex.org/W2022151749","https://openalex.org/W2356672495","https://openalex.org/W954397266","https://openalex.org/W4387611682","https://openalex.org/W1968052682","https://openalex.org/W4237761817","https://openalex.org/W7092486","https://openalex.org/W2802714615","https://openalex.org/W7135753139"],"abstract_inverted_index":{"Iron":[0,96],"is":[1,12,49,104,187,220],"an":[2],"important":[3],"bio-catalyst":[4],"of":[5,25,41,62,108,160,182,192,210,229],"oxidation-reduction":[6],"reactions":[7],"in":[8,32,59,82,129,157,165,196,216,242,247],"the":[9,23,50,60,70,78,158,214],"cell":[10],"and":[11,38,57,86,103,113,132,138,143,149,164,174,179,206,222,251],"essential":[13],"for":[14,54],"life.":[15],"Paradoxically,":[16],"it":[17],"may":[18,45,153,239],"also":[19],"be":[20],"lethal":[21],"when":[22],"fraction":[24],"redox-active":[26,161,257],"metal":[27,162,166,183,194,211,258],"ions":[28,163],"exceeds":[29],"that":[30,168],"sequestered":[31],"specialized":[33],"proteins":[34],"or":[35,124],"cellular":[36],"compartments,":[37],"uncontrolled":[39],"production":[40],"free":[42,111],"radical":[43],"species":[44],"arise.":[46],"The":[47,177,227],"liver":[48,215,245],"main":[51],"body":[52],"site":[53],"iron":[55,63,71,84,91,217],"stores":[56],"central":[58],"regulation":[61],"homeostasis.":[64],"Important":[65],"iron-proteins,":[66],"such":[67,134,202],"as":[68,135,145,147,203],"hepcidin,":[69],"regulatory":[72],"hormone,":[73],"are":[74,254],"specifically":[75],"produced":[76],"by":[77,120,125,256],"liver.":[79],"Pathogenic":[80],"mutations":[81],"hepatic":[83,130,139],"transporters":[85],"regulators":[87],"lead":[88],"to":[89,106,171,232],"hereditary":[90],"overload":[92,195,218],"diseases,":[93],"including":[94],"hemochromatosis.":[95],"toxicity":[97],"depends":[98],"on":[99],"its":[100],"excessive":[101],"accumulation":[102],"due":[105],"promotion":[107],"oxidant":[109],"stress:":[110],"radicals":[112],"membrane":[114],"oxidation":[115],"by-products":[116],"cause":[117,154],"hepatocellular":[118],"death":[119],"triggering":[121],"organelle":[122],"dysfunction,":[123],"activating":[126],"cells":[127,137],"involved":[128],"inflammation":[131],"fibrogenesis,":[133],"Kupffer":[136],"stellate":[140],"cells.":[141],"Xenobiotics":[142],"hepatotoxins":[144],"well":[146],"immunological":[148],"host":[150],"defense":[151],"mechanisms":[152],"subtle":[155],"changes":[156],"pool":[159],"compartmentalization":[167],"potentially":[169],"contribute":[170],"hepatotoxic,":[172],"inflammatory":[173],"fibrogenic":[175,252],"events.":[176],"hepatotoxic":[178],"profibrogenic":[180],"potential":[181],"ions,":[184],"particularly":[185,237],"iron,":[186,238],"dramatic":[188],"at":[189],"moderate":[190],"levels":[191],"tissue":[193],"concomitance":[197],"with":[198],"other":[199,243],"inciting":[200],"insults,":[201],"alcohol":[204],"abuse":[205],"viral":[207],"hepatitis.":[208],"Removal":[209],"excess":[212],"from":[213],"diseases":[219,246],"beneficial":[221],"prevents":[223],"progression":[224],"toward":[225],"cirrhosis.":[226],"development":[228],"drugs":[230],"able":[231],"block":[233],"catalytically":[234],"active":[235],"metals,":[236],"prove":[240],"effective":[241],"chronic":[244],"which":[248],"inflammatory,":[249],"degenerative":[250],"processes":[253],"fueled":[255],"ions.":[259]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
