{"id":"https://openalex.org/W2409635342","doi":null,"title":"Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.","display_name":"Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.","publication_year":1995,"publication_date":"1995-10-19","ids":{"openalex":"https://openalex.org/W2409635342","mag":"2409635342","pmid":"https://pubmed.ncbi.nlm.nih.gov/7478573"},"language":"en","primary_location":{"id":"pmid:7478573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7478573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112147820","display_name":"Chang Yan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Y Chen","raw_affiliation_strings":["Cancer Research Center, Boston University School of Medicine, Massachusetts 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Center, Boston University School of Medicine, Massachusetts 02118, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083735394","display_name":"Douglas V. Faller","orcid":"https://orcid.org/0000-0002-2454-3478","observed_orcids":["https://orcid.org/0000-0002-2454-3478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D V Faller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9799,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.96645796,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"8","first_page":"1487","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.29589998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ras-p21","display_name":"p21ras","score":0.9409999847412109},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.875},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.5580000281333923},{"id":"https://openalex.org/keywords/bcl-2-phosphorylation","display_name":"Bcl-2 phosphorylation","score":0.824999988079071},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.6230000257492065},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/t-lymphoblastoid-cells","display_name":"T-lymphoblastoid cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8131798505783081},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.7404059171676636},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.7382982969284058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6852809190750122},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6067790389060974},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5663244724273682},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5435732007026672},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4793068468570709},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47723984718322754},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47028565406799316},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4257369637489319},{"id":"https://openalex.org/C2777061661","wikidata":"https://www.wikidata.org/wiki/Q423934","display_name":"Phosphoprotein","level":3,"score":0.41216111183166504},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34560441970825195},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2314445674419403},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1634025275707245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1503584384918213},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08496299386024475},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0720754861831665}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7478573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7478573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2409635342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7478573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993112793","https://openalex.org/W1969742569","https://openalex.org/W2073038957","https://openalex.org/W2015190128","https://openalex.org/W2189096243","https://openalex.org/W1965069029","https://openalex.org/W1972749842","https://openalex.org/W1747665148","https://openalex.org/W2061432892","https://openalex.org/W2070090561"],"abstract_inverted_index":{"Normal":[0],"and":[1,18,89,109,149],"activated":[2,38,121],"Ras":[3],"proteins":[4],"are":[5,23],"known":[6],"to":[7,53,125],"act":[8],"as":[9],"signal":[10],"transducers,":[11],"mediating":[12],"mitogenic":[13,29],"responses.":[14],"Interactions":[15],"of":[16,28,37,60,65,74,85,113,120,127,135],"p21ras":[17],"protein":[19],"kinase":[20],"C":[21],"(PKC)":[22],"required":[24],"in":[25,40,67,117,123,139],"a":[26,43,107],"number":[27],"or":[30,58,137],"activation":[31],"signaling":[32],"pathways.":[33],"The":[34],"constitutive":[35],"expression":[36,64],"v-Haras":[39],"Jurkat":[41],"cells,":[42],"human":[44],"T":[45],"lymphoblastoid":[46],"cell":[47,79],"line,":[48],"renders":[49],"the":[50,63,94,110,118],"cells":[51,140],"susceptible":[52],"apoptosis":[54,71,138],"during":[55,72],"transient":[56],"down-regulation":[57],"inhibition":[59,126],"PKC.":[61,128],"Similarly,":[62],"v-Ki-ras":[66],"murine":[68],"fibroblasts":[69],"induces":[70],"suppression":[73,84],"PKC":[75,87,148],"activity.":[76],"This":[77],"Ras-specific":[78],"death":[80],"is":[81,106,115],"dependent":[82],"upon":[83],"cellular":[86],"activity,":[88],"can":[90],"be":[91],"blocked":[92],"by":[93],"survival-promoting":[95],"bcl-2":[96],"gene":[97],"product.":[98],"In":[99],"vivo":[100],"phosphorylation":[101,111],"studies":[102],"indicate":[103],"that":[104],"Bcl-2":[105,114],"phosphoprotein,":[108],"state":[112],"modulated":[116],"setting":[119],"p21Ha-ras":[122],"response":[124],"These":[129],"findings":[130],"suggest":[131],"an":[132],"interactive":[133],"regulation":[134],"growth":[136],"which":[141],"involves":[142],"at":[143],"least":[144],"three":[145],"molecules:":[146],"p21ras,":[147],"Bcl-2.":[150]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
