{"id":"https://openalex.org/W2409601017","doi":null,"title":"[Evolution of aneuploidy from diploid colorectal carcinoma as revealed by the analyses of ploidy heterogeneity and Ras mutation patterns].","display_name":"[Evolution of aneuploidy from diploid colorectal carcinoma as revealed by the analyses of ploidy heterogeneity and Ras mutation patterns].","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W2409601017","mag":"2409601017","pmid":"https://pubmed.ncbi.nlm.nih.gov/7611777"},"language":"ja","primary_location":{"id":"pmid:7611777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7611777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078617499","display_name":"Hiroyuki Sugihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Sugihara","raw_affiliation_strings":["Dept. of Pathology, Kyoto Prefectural University of Medicine","Department of Pathology Kyoto Prefectural University of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pathology, Kyoto Prefectural University of Medicine","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Pathology Kyoto Prefectural University of Medicine","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012037200","display_name":"Kanade Katsura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Katsura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079228591","display_name":"Kyoko Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yokoyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Hattori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hattori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"S Fujita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34566116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22 Suppl 2","issue":null,"first_page":"140","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/kras-codon-12-mutation","display_name":"K-ras codon 12 mutation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tumor-clonality","display_name":"tumor clonality","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.9352037310600281},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.8951654434204102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7880841493606567},{"id":"https://openalex.org/C2776626444","wikidata":"https://www.wikidata.org/wiki/Q213410","display_name":"Polyploid","level":4,"score":0.6241172552108765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4475204348564148},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4304066300392151},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4110139012336731},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3300217092037201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.061241358518600464},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.054444849491119385},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7611777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7611777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},{"id":"mag:2409601017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7611777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1556604979","https://openalex.org/W2466037492","https://openalex.org/W2018130509","https://openalex.org/W2135521209","https://openalex.org/W2150170909","https://openalex.org/W1999803187","https://openalex.org/W2095133141","https://openalex.org/W2043050170","https://openalex.org/W2062475303","https://openalex.org/W1998813778"],"abstract_inverted_index":{"UNLABELLED:":[0],"To":[1,52],"analyze":[2],"ploidy":[3,13,41,152],"alterations":[4],"during":[5],"progression":[6],"of":[7,19,36,48,56,107,139,146],"colorectal":[8],"tumors,":[9],"we":[10],"mapped":[11],"the":[12,32,37,54,60,64,86,121,131,147,158,176],"constitutions":[14],"by":[15,45],"cytofluorometry":[16],"using":[17],"(measurements":[18],"metaphase":[20],"cells":[21,132,172],"in)":[22],"tissue":[23,33,102],"sections":[24,103],"as":[25,27],"well":[26],"cell":[28,179],"suspensions":[29],"isolated":[30,133],"from":[31,104,134,175],"sections.":[34],"Clonality":[35],"tumor":[38,62,75,178],"with":[39,114,142,150,157,181],"heterogeneous":[40,151],"constitution":[42],"was":[43,99,117,128],"checked":[44],"mutation":[46,156,159],"pattern":[47],"K-ras":[49],"codon":[50],"12.":[51],"assess":[53],"significance":[55],"polyploidy":[57,83],"detected":[58,100,129],"in":[59,95,101,120,130],"diploid":[61,74,80,112,135,163,177],"component,":[63],"present":[65],"materials":[66],"were":[67,90],"confined":[68],"to":[69,162],"23":[70],"tumors":[71,81,109,141,149],"that":[72,84,110,170],"contained":[73],"cells.":[76],"RESULTS:":[77],"1)":[78],"Eight":[79],"without":[82],"invaded":[85],"submucosa":[87],"or":[88],"deeper":[89],"greater":[91],"than":[92],"2":[93,140],"cm":[94],"diameter.":[96],"2)":[97],"Aneuploidy":[98],"9":[105],"out":[106],"15":[108],"had":[111,154],"component":[113],"polyploidy,":[115,182],"and":[116,164],"occasionally":[118],"predominant":[119],"extramucosal":[122],"invasive":[123],"parts.":[124,166],"3)":[125],"Near-diploid":[126],"aneuploidy":[127],"(+":[136],"polyploid)":[137],"regions":[138],"aneuploidy.":[143,187],"4)":[144],"Three":[145],"6":[148],"constituents":[153],"ras":[155],"patterns":[160],"common":[161],"aneuploid":[165,171],"These":[167],"findings":[168],"suggest":[169],"evolve":[173],"preferentially":[174],"population":[180],"which":[183],"often":[184],"include":[185],"near-diploid":[186]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
