{"id":"https://openalex.org/W2409588678","doi":null,"title":"[Stability of 5-fluorouracil solutions according to different parameters].","display_name":"[Stability of 5-fluorouracil solutions according to different parameters].","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2409588678","mag":"2409588678","pmid":"https://pubmed.ncbi.nlm.nih.gov/8745668"},"language":"fr","primary_location":{"id":"pmid:8745668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8745668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du cancer","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009787714","display_name":"Muriel Barberi\u2010Heyob","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Barberi-Heyob","raw_affiliation_strings":["Laboratoire de recherche en oncologie, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de recherche en oncologie, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013503712","display_name":"M Watelet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Watelet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028755998","display_name":"J.L. Merlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Merlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045224198","display_name":"C Bleger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Bleger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"B Schroeder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Schroeder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.35346425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"82","issue":"12","first_page":"1025","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13279","display_name":"Safe Handling of Antineoplastic Drugs","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3609","display_name":"Occupational Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/storage-conditions","display_name":"storage conditions","score":0.6019999980926514},{"id":"https://openalex.org/keywords/crystallization","display_name":"crystallization","score":0.734000027179718},{"id":"https://openalex.org/keywords/pharmaceutical-formulations","display_name":"drug formulation","score":0.3720000088214874},{"id":"https://openalex.org/keywords/light-exposure","display_name":"light exposure","score":0.5820000171661377},{"id":"https://openalex.org/keywords/temperature-effects","display_name":"temperature effects","score":0.7760000228881836},{"id":"https://openalex.org/keywords/drug-concentration","display_name":"drug concentration","score":0.4300000071525574},{"id":"https://openalex.org/keywords/plastic-bags","display_name":"plastic bags","score":0.5649999976158142},{"id":"https://openalex.org/keywords/syringes","display_name":"syringes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pharmaceutical-excipients","display_name":"pharmaceutical excipients","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C2778562268","wikidata":"https://www.wikidata.org/wiki/Q102769","display_name":"Sodium hydroxide","level":2,"score":0.6296262741088867},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6061273813247681},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5576608777046204},{"id":"https://openalex.org/C3019474993","wikidata":"https://www.wikidata.org/wiki/Q1539975","display_name":"Sterile water","level":2,"score":0.4541572332382202},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.37856364250183105},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3254355490207672},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0879259705543518},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002021","descriptor_name":"Buffers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004349","descriptor_name":"Drug Packaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004356","descriptor_name":"Drug Storage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008029","descriptor_name":"Lighting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8745668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8745668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du cancer","raw_type":"Comparative Study"},{"id":"mag:2409588678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8745668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966275239","https://openalex.org/W2333184122","https://openalex.org/W2735718414","https://openalex.org/W1572462072","https://openalex.org/W4220820862","https://openalex.org/W2135497024","https://openalex.org/W1568774821","https://openalex.org/W2009922298","https://openalex.org/W1839402750","https://openalex.org/W1968123121"],"abstract_inverted_index":{"To":[0],"follow":[1],"therapeutic":[2],"evolutions":[3],"and":[4,47,53,61,65,72,132,151,182,228,241],"to":[5,43,108,208,291],"ensure":[6],"an":[7],"international":[8],"homogeneity,":[9],"\"Produits":[10],"Roche\"":[11],"Laboratories":[12],"recently":[13],"modified":[14],"the":[15,20,37,89,99,135,156,167,191,201,221,254,280,292],"conditioning":[16],"of":[17,40,101,117,137,158,178,190,220,234,244,284,294],"5-fluorouracil":[18],"(5-FU):":[19],"Tris":[21],"buffer":[22],"was":[23,75,85,149],"replaced":[24],"by":[25,77],"sodium":[26],"hydroxide":[27],"(pH":[28],"9.4).":[29],"For":[30,111,128,236],"these":[31],"newly-formulated":[32],"5-FU":[33,74,109,118,281],"solutions,":[34],"we":[35,96,215,246],"studied":[36],"optimal":[38,203],"conditions":[39],"storage":[41,168,206,256,267],"according":[42,107],"concentration":[44],"(0.2;":[45],"1.5":[46,242],"10":[48,131,263],"mg/ml),":[49],"temperature":[50],"(4,":[51],"21":[52,172],"37":[54],"degrees":[55,94,173,298],"C),":[56],"light":[57],"(without,":[58],"natural,":[59],"artificial)":[60],"duration":[62],"(7,":[63],"15":[64],"30":[66,232],"days)":[67],"for":[68,88,126,180],"plastic":[69,112,237],"bags,":[70],"syringes":[71,183],"cassettes.":[73],"dosaged":[76],"High":[78],"Performance":[79],"Liquid":[80],"Chromatography":[81],"(HPLC).":[82],"No":[83],"staining":[84],"observed,":[86],"but":[87],"samples":[90],"placed":[91],"at":[92,114,130,171,184,239,296],"4":[93,297],"C,":[95],"detected":[97],"macroscopically":[98],"apparition":[100],"crystals,":[102],"more":[103],"or":[104],"less":[105,141],"rapidly":[106],"concentration.":[110],"bags":[113,238],"0.2":[115,240],"mg/ml":[116,186,243,264],"in":[119,140,153,169,200,271],"NaCl":[120],"(0.9%),":[121],"48":[122],"hours":[123],"were":[124],"sufficient":[125],"crystallisation.":[127],"preparations":[129],"50":[133,185],"mg/ml,":[134],"formation":[136,157],"crystals":[138],"occurred":[139],"than":[142],"24":[143],"hours.":[144],"However,":[145,199],"no":[146,277],"microscopic":[147],"analysis":[148],"performed":[150],"therefore,":[152],"shorter":[154],"delays,":[155],"microcrystals":[159],"can":[160,273],"be":[161,212,274,289],"envisaged.":[162],"After":[163],"7":[164,269],"days,":[165],"only":[166],"darkness":[170,272],"C":[174],"yields":[175],"good":[176],"results":[177],"stability":[179],"cassettes":[181],"with":[187,276],"a":[188,205,217,266],"degradation":[189],"active":[192,222],"component":[193],"that":[194],"does":[195],"not":[196,248],"exceed":[197],"2%.":[198],"same":[202],"conditions,":[204,257],"superior":[207],"14":[209,260],"days":[210,233,270],"cannot":[211],"envisaged":[213,275],"since":[214],"noted":[216],"10%":[218],"diminution":[219],"component,":[223],"then":[224],"this":[225],"loss":[226],"intensifies":[227],"reaches":[229],"18%":[230],"after":[231],"storage.":[235],"5-FU,":[245],"did":[247],"measure":[249],"any":[250],"significant":[251],"difference":[252],"between":[253],"various":[255],"even":[258],"during":[259,268],"days.":[261],"At":[262],"concentration,":[265,285],"repercussion":[278],"on":[279],"stability.":[282],"Independently":[283],"special":[286],"attention":[287],"must":[288],"paid":[290],"risk":[293],"crystallisation":[295],"C.":[299]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}