{"id":"https://openalex.org/W2409575223","doi":null,"title":"[Expressions and clinical significance of high mobility group box-1 mRNA and protein in laryngeal squamous cell carcinoma tissues and serum].","display_name":"[Expressions and clinical significance of high mobility group box-1 mRNA and protein in laryngeal squamous cell carcinoma tissues and serum].","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2409575223","mag":"2409575223","pmid":"https://pubmed.ncbi.nlm.nih.gov/22932142"},"language":"zh","primary_location":{"id":"pmid:22932142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22932142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101774615","display_name":"Ying Guo","orcid":"https://orcid.org/0000-0001-6898-418X","observed_orcids":["https://orcid.org/0000-0001-6898-418X"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Guo","raw_affiliation_strings":["Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694769","display_name":"Yong Liu","orcid":"https://orcid.org/0000-0002-0574-2877","observed_orcids":["https://orcid.org/0000-0002-0574-2877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113965887","display_name":"Pingqing Tan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping-qing Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Guo Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102910728","display_name":"Zhongwu Su","orcid":"https://orcid.org/0000-0003-0758-9308","observed_orcids":["https://orcid.org/0000-0003-0758-9308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhong-wu Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082719789","display_name":"Yongquan Tian","orcid":"https://orcid.org/0000-0002-0497-2494","observed_orcids":["https://orcid.org/0000-0002-0497-2494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-quan Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100974682","display_name":"Yuanzheng Qiu","orcid":"https://orcid.org/0009-0004-6732-2108","observed_orcids":["https://orcid.org/0009-0004-6732-2108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan-zheng Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9798,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.74201389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"47","issue":"6","first_page":"487","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.12120000272989273,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.7369999885559082},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.847000002861023},{"id":"https://openalex.org/keywords/t-stage","display_name":"T stage","score":0.7850000262260437},{"id":"https://openalex.org/keywords/clinical-stage","display_name":"clinical stage","score":0.8259999752044678},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6851575374603271},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6825557351112366},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6601666212081909},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.6561790704727173},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5636064410209656},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.45278945565223694},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44237300753593445},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.43982231616973877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3590524196624756},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3522559702396393},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3482140898704529},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21296831965446472},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12702569365501404},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07283833622932434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22932142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22932142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery","raw_type":"English Abstract"},{"id":"mag:2409575223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22932142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2465218273","https://openalex.org/W2895304251","https://openalex.org/W2027701512","https://openalex.org/W2412713056","https://openalex.org/W2367160649","https://openalex.org/W2383052594","https://openalex.org/W4395084762","https://openalex.org/W2347698850","https://openalex.org/W2367208966","https://openalex.org/W1986342867"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,15,46,54,71,92,129],"mRNA":[4,50,95,154,226],"and":[5,18,28,39,51,56,75,104,114,142,155,172,186,190,205,213,227,246],"protein":[6,52,68,132,156,199,228],"expressions":[7,47,229],"of":[8,20,48,98,135,159,230],"high":[9],"mobility":[10],"group":[11],"box-1":[12],"(HMGB1)":[13],"in":[14,53,61,70,76,101,105,201,235],"tumor":[16,188],"tissues":[17,60,103,109],"sera":[19],"patients":[21,63,72,202],"with":[22,64,73,82,163,182,203,241],"laryngeal":[23],"squamous":[24],"cell":[25],"carcinoma":[26],"(LSCC)":[27],"their":[29],"clinical":[30,166,244],"significance.":[31],"METHODS:":[32],"Semi-quantitative":[33],"reverse":[34],"transcriptase-polymerase":[35],"chain":[36],"reaction":[37],"(RT-PCR)":[38],"Western":[40,125],"blot":[41,126],"were":[42,80,110,138,161,208,232,238],"used":[43],"to":[44],"detected":[45,81],"HMGB1":[49,67,99,136,160,198,231],"tumors":[55],"adjacent":[57,106],"normal":[58,107],"epithelial":[59,108],"30":[62],"LSCC.":[65],"Serum":[66],"levels":[69,97,134,158,200],"LSCC":[74,102,204],"10":[77],"healthy":[78,206],"volunteers":[79,207],"enzyme-linked":[83],"immunosorbent":[84],"adsorption":[85],"experiment":[86],"(ELISA).":[87],"RESULTS:":[88],"RT-PCR":[89],"demonstrated":[90],"that":[91,128],"mean":[93,130],"relative":[94,131],"expression":[96,133,157],"(HMGB1/GAPDH)":[100],"1.25":[111],"\u00b1":[112,116,140,144,210,215],"0.12":[113],"0.32":[115],"0.04,":[117],"respectively":[118],"(t":[119,146,218],"=":[120,147,219],"40.27,":[121],"P":[122,149,175,193,221],"<":[123,150,176],"0.05).":[124,195,223],"revealed":[127],"(HMGB1/\u03b2-actin)":[137],"1.29":[139],"0.10":[141],"0.34":[143],"0.03":[145],"49.84,":[148],"0.05),":[151,177],"respectively.":[152],"Both":[153,225],"associated":[162,239],"T":[164,242],"stage,":[165,167,243],"lymph":[168,247],"node":[169,248],"metastasis":[170],"status":[171],"smoking":[173],"(all":[174,192],"but":[178],"no":[179],"significant":[180],"correlation":[181],"age,":[183],"alcohol":[184],"consumption":[185],"primary":[187],"grade":[189],"location":[191],">":[194,222],"Mean":[196],"serum":[197],"(24.80":[209],"14.08)":[211],"ng/ml":[212,217],"(23.58":[214],"14.69)":[216],"0.37,":[220],"CONCLUSIONS:":[224],"obviously":[233],"elevated":[234],"LSCC,":[236],"which":[237],"closely":[240],"stage":[245],"metastasis.":[249]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}