{"id":"https://openalex.org/W2409568440","doi":null,"title":"Variant subpopulations of Staphylococcus aureus as cause of persistent and recurrent infections.","display_name":"Variant subpopulations of Staphylococcus aureus as cause of persistent and recurrent infections.","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W2409568440","mag":"2409568440","pmid":"https://pubmed.ncbi.nlm.nih.gov/7889317"},"language":"en","primary_location":{"id":"pmid:7889317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7889317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious agents and disease","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086481621","display_name":"Richard A. Proctor","orcid":"https://orcid.org/0000-0003-3011-7958","observed_orcids":["https://orcid.org/0000-0003-3011-7958"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Proctor","raw_affiliation_strings":["Department of Medicine, University of Wisconsin Medical School, Madison 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin Medical School, Madison 53706","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035775142","display_name":"James M Balwit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Balwit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027594295","display_name":"\u00d3mar Vesga","orcid":"https://orcid.org/0000-0002-4308-7930","observed_orcids":["https://orcid.org/0000-0002-4308-7930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Vesga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1684,"has_fulltext":false,"cited_by_count":137,"citation_normalized_percentile":{"value":0.87958083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"6","first_page":"302","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/small-colony-variants","display_name":"small colony variants","score":0.9990000128746033},{"id":"https://openalex.org/keywords/persistent-infection","display_name":"persistent infection","score":0.8960000276565552},{"id":"https://openalex.org/keywords/recurrent-infections","display_name":"recurrent infections","score":0.9639999866485596},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9649999737739563},{"id":"https://openalex.org/keywords/alpha-toxin","display_name":"alpha-toxin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/infection-relapse","display_name":"infection relapse","score":0.8199999928474426},{"id":"https://openalex.org/keywords/colony-morphology","display_name":"colony morphology","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8809399604797363},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7012583613395691},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6818852424621582},{"id":"https://openalex.org/C2910180214","wikidata":"https://www.wikidata.org/wiki/Q96072446","display_name":"Colony morphology","level":3,"score":0.4933229982852936},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4891234040260315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4883415400981903},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.46301552653312683},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.4460950195789337},{"id":"https://openalex.org/C2992965680","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Clinical microbiology","level":2,"score":0.4222147464752197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36109498143196106},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3175114393234253},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15336069464683533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1337956190109253}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7889317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7889317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious agents and disease","raw_type":"Journal Article"},{"id":"mag:2409568440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7889317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2156726015","https://openalex.org/W2082352465","https://openalex.org/W2005955658","https://openalex.org/W167245868","https://openalex.org/W2088960594","https://openalex.org/W2005075413","https://openalex.org/W2152594398","https://openalex.org/W2408385638","https://openalex.org/W2079774537","https://openalex.org/W2105614444"],"abstract_inverted_index":{"While":[0],"S.":[1,115],"aureus":[2,116],"small":[3],"colony":[4,79],"variants":[5],"(SCVs)":[6],"have":[7,17],"been":[8,20,55],"recognized":[9],"in":[10,45,89],"clinical":[11,91],"materials":[12],"for":[13,31,109],"decades,":[14],"only":[15],"recently":[16],"these":[18,46,82],"strains":[19,84],"linked":[21],"to":[22,35,42,57,71,98,107],"persistent,":[23],"resistant,":[24],"and":[25,76,94,113],"relapsing":[26,112],"infections.":[27,117],"The":[28],"biochemical":[29],"basis":[30],"this":[32],"phenotype":[33],"appears":[34],"be":[36,86,96],"reduced":[37],"electron":[38],"transport,":[39],"which":[40],"leads":[41],"many":[43],"changes":[44],"organisms,":[47],"including":[48],"decreased":[49],"alpha-toxin":[50,53],"production.":[51],"Reduced":[52],"has":[54],"found":[56],"facilitate":[58],"bacterial":[59],"survival":[60],"within":[61],"cultured":[62],"endothelial":[63],"cells.":[64],"This":[65],"SCV":[66],"subpopulation":[67],"is":[68],"more":[69],"resistant":[70,83,97,114],"antibiotics,":[72],"grows":[73],"very":[74],"slowly,":[75],"demonstrates":[77],"unusual":[78],"morphology.":[80],"Hence,":[81],"can":[85],"easily":[87],"overloaded":[88],"the":[90,105],"microbiology":[92],"laboratory,":[93],"may":[95],"conventional":[99],"antibiotic":[100],"therapy.":[101],"Clinicians":[102],"should":[103],"ask":[104],"laboratory":[106],"search":[108],"SCVs":[110],"with":[111]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
