{"id":"https://openalex.org/W2409564652","doi":null,"title":"Immunofluorometric study of Bcl-2 and Bax expression in clinical fresh tumor samples from breast cancer patients.","display_name":"Immunofluorometric study of Bcl-2 and Bax expression in clinical fresh tumor samples from breast cancer patients.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2409564652","mag":"2409564652","pmid":"https://pubmed.ncbi.nlm.nih.gov/12680147"},"language":"en","primary_location":{"id":"pmid:12680147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12680147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008044041","display_name":"Fernando Mart\u00ednez\u2010Arribas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Mart\u00ednez-Arribas","raw_affiliation_strings":["Fundaci\u00f3n Tejerina-Centro de Patolog\u00eda de la Mama, Calle Jos\u00e9 Abascal 40, 28003 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n Tejerina-Centro de Patolog\u00eda de la Mama, Calle Jos\u00e9 Abascal 40, 28003 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111983598","display_name":"Mar\u00eda-Jos\u00e9 N\u00fa\u00f1ez-Villar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J N\u00fa\u00f1ez-Villar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065128576","display_name":"Lucas Ar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A R Lucas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075656728","display_name":"Jaime S\u00e1nchez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S\u00e1nchez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108537832","display_name":"Armando Tejerina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tejerina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076986738","display_name":"Jos\u00e9 Schneider","orcid":"https://orcid.org/0000-0003-4503-9956","observed_orcids":["https://orcid.org/0000-0003-4503-9956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Schneider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5105,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.8207789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"23","issue":"1B","first_page":"565","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.15150000154972076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hormone-receptors","display_name":"hormone receptors","score":0.6449999809265137},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/c-erbb-2","display_name":"c-erbB-2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.6449999809265137},{"id":"https://openalex.org/keywords/dna-ploidy","display_name":"DNA ploidy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8109999895095825},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9020000100135803},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4050000011920929},{"id":"https://openalex.org/keywords/immunofluorescence","display_name":"immunofluorescence","score":0.6809999942779541},{"id":"https://openalex.org/keywords/gene-expression-correlation","display_name":"gene expression correlation","score":0.45399999618530273},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6230000257492065},{"id":"https://openalex.org/keywords/antiapoptotic-genes","display_name":"anti-apoptotic genes","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7946734428405762},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6588101387023926},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5824418663978577},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5746866464614868},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5557085871696472},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.5514567494392395},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5207121968269348},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4871344268321991},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47574564814567566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4383782744407654},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3899405300617218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3773040473461151},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34279000759124756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3415260910987854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27733612060546875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011003","descriptor_name":"Ploidies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015200","descriptor_name":"Fluoroimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12680147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12680147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2409564652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12680147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009042807","https://openalex.org/W2124182127","https://openalex.org/W1040485","https://openalex.org/W2414638174","https://openalex.org/W2022000463","https://openalex.org/W2363446699","https://openalex.org/W2011174531","https://openalex.org/W4401501717","https://openalex.org/W2164059332","https://openalex.org/W2118975674"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"balance":[2],"between":[3],"the":[4,7,12,22,48,61,72,92,95,110,119,130,158,163,180,184,187,219,230,267,292,332,347,355,364],"expression":[5,31,49,93,120,185,192,215,245,251,280,337,353],"of":[6,21,25,50,71,89,94,121,142,179,186,291,312,349,367],"antiapoptotic":[8],"gene":[9,14],"Bcl-2":[10,28,97,191,295,298,336,350],"and":[11,29,58,68,98,125,129,147,149,161,200,249,255,274,299,319],"proapoptotic":[13],"Bax":[15,30,99,279,352],"is":[16],"considered":[17],"a":[18,37,341],"good":[19],"indicator":[20],"apoptotic":[23,235,343],"activity":[24],"tumor":[26,78],"cells.":[27],"seem":[32],"also":[33,104],"to":[34,46,59,109,117,174,229,330,360],"individually":[35],"play":[36],"prognostic":[38],"role":[39],"in":[40,53,172,216,305,322,338,354],"breast":[41,55,82,307],"cancer.":[42],"Our":[43],"aim":[44],"was":[45,103,258],"study":[47,118,231,268],"both":[51,156],"genes":[52],"fresh":[54],"cancer":[56,83,308],"samples,":[57],"correlate":[60,283],"obtained":[62],"results":[63],"with":[64,139,195,210,242,284,317],"other":[65,286],"available":[66],"clinical":[67,287,306],"biological":[69,289],"parameters":[70,290],"tumors.":[73,325],"MATERIALS":[74],"AND":[75],"METHODS:":[76],"Fresh":[77],"specimens":[79,309],"from":[80],"86":[81],"patients":[84,135,165],"were":[85,113,153,227,264],"studied":[86,188],"by":[87,310,363],"means":[88,311],"immunofluorocytometry":[90],"for":[91,115,157,162],"apoptosis-associated":[96],"genes.":[100],"Additionally,":[101],"DNA-ploidy":[102],"measured.":[105],"Paraffin":[106],"blocks":[107],"corresponding":[108],"same":[111,356],"tumors":[112,226,263],"used":[114],"immunohistochemistry,":[116],"hormone":[122],"receptors":[123],"(ER":[124],"PR),":[126],"p53,":[127],"c-erb-B2":[128,211,250],"Ki67":[131],"labelling":[132],"index.":[133],"Fourteen":[134],"had":[136],"been":[137],"treated":[138,225,262],"four":[140],"cycles":[141],"induction":[143],"chemotherapy":[144],"(cyclo-phosphamide,":[145],"adriamycin":[146],"5-fluorouracil),":[148],"separate":[150],"statistical":[151],"analyses":[152],"carried":[154],"out":[155],"whole":[159],"group,":[160],"62":[164],"not":[166,270,282,359],"having":[167],"received":[168],"any":[169,176,285],"treatment":[170,182],"whatsoever,":[171],"order":[173],"exclude":[175],"potential":[177],"influence":[178],"chemotherapeutic":[181],"on":[183],"antigens.":[189],"RESULTS:":[190],"correlated":[193,240],"significantly":[194,241,315],"estrogen":[196],"(p":[197,202,212,246,252,271],"=":[198,203,213,247,253,272,276],"0.002)":[199],"progesterone":[201,243],"0.012)":[204],"receptor":[205,244],"expression,":[206],"as":[207,209],"well":[208],"0.045)":[214],"chemotherapy-na\u00efve":[217],"tumors,":[218,293],"correlation":[220,257],"being":[221],"completely":[222],"lost":[223],"if":[224],"added":[228],"group.":[232],"A":[233],"high":[234,342],"index":[236],"(Bcl2/Bax":[237],"<":[238],"0.5)":[239],"0.037)":[248],"0.018),":[254],"this":[256],"maintained,":[259],"whether":[260],"previously":[261,323],"included":[265],"into":[266],"or":[269,288],"0.038":[273],"p":[275],"0.027,":[277],"respectively).":[278],"did":[281],"including":[294],"expression.":[296],"CONCLUSION:":[297],"Bax-expression":[300],"can":[301],"be":[302,331,361],"easily":[303],"determined":[304],"immunofluorocytometry.":[313],"Bcl-2-expression":[314],"correlates":[316],"hormone-receptor-":[318],"c-erb-B2-expression":[320],"exclusively":[321],"untreated":[324],"This,":[326],"however,":[327],"seems":[328,358],"only":[329],"case":[333],"when":[334],"considering":[335],"isolation,":[339],"since":[340],"index,":[344],"which":[345],"considers":[346],"ratio":[348],"versus":[351],"tumor,":[357],"affected":[362],"previous":[365],"use":[366],"chemotherapy.":[368]},"counts_by_year":[{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
