{"id":"https://openalex.org/W2409528478","doi":null,"title":"Evaluation of the hypothalamic-pituitary-gonadal axis in males with systemic lupus erythematosus.","display_name":"Evaluation of the hypothalamic-pituitary-gonadal axis in males with systemic lupus erythematosus.","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2409528478","mag":"2409528478","pmid":"https://pubmed.ncbi.nlm.nih.gov/9632070"},"language":"en","primary_location":{"id":"pmid:9632070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9632070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085597243","display_name":"S T Vilarinho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S T Vilarinho","raw_affiliation_strings":["Department of Clinical Medicine, School of Medicine, State University of Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, School of Medicine, State University of Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056941981","display_name":"L\u00edlian Tereza Lavras Costallat","orcid":"https://orcid.org/0000-0002-3077-9479","observed_orcids":["https://orcid.org/0000-0002-3077-9479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L T Costallat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1902,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.78322522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"25","issue":"6","first_page":"1097","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.13490000367164612,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/male-patients","display_name":"male patients","score":0.7009999752044678},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.7089999914169312},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9309999942779541},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9810000061988831},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.796999990940094},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/androstenedione","display_name":"androstenedione","score":0.9480000138282776},{"id":"https://openalex.org/keywords/leydig-cell-function","display_name":"Leydig cell function","score":0.7459999918937683},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin-stimulation","display_name":"human chorionic gonadotropin stimulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/glucocorticoid-therapy","display_name":"glucocorticoid therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/testicular-function","display_name":"testicular function","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8800047039985657},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8643149137496948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7486281991004944},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6745526790618896},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6153109073638916},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.5973888635635376},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5657310485839844},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.5365156531333923},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5049040913581848},{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.5047701597213745},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4921378493309021},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.4745382070541382},{"id":"https://openalex.org/C146819174","wikidata":"https://www.wikidata.org/wiki/Q1703595","display_name":"Hypothalamic\u2013pituitary\u2013gonadal axis","level":4,"score":0.437202513217926},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.27305975556373596},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9632070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9632070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:2409528478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9632070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113314714","https://openalex.org/W2419128767","https://openalex.org/W2404303578","https://openalex.org/W2058256922","https://openalex.org/W2081420601","https://openalex.org/W2013667866","https://openalex.org/W2584182091","https://openalex.org/W2384858855","https://openalex.org/W2004099162","https://openalex.org/W2360977519"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,173,214],"hypothalamic-pituitary-gonadal":[4],"axis":[5],"in":[6,78,147,150,179,182,189,207,219],"male":[7,18],"patients":[8,19,148,180,220],"with":[9,20,25,90,107,122,159,197,221,236],"systemic":[10],"lupus":[11],"erythematosus":[12],"(SLE).":[13],"METHODS:":[14],"We":[15],"studied":[16],"7":[17],"SLE":[21,41,123],"and":[22,37,71,86,99,103,130,141],"compared":[23],"them":[24],"10":[26],"age":[27],"matched":[28],"healthy":[29],"controls.":[30,151,183],"Clinical":[31],"data,":[32],"laboratory":[33],"tests,":[34],"drugs":[35],"used,":[36],"disease":[38],"activity":[39],"for":[40,115],"(SLE":[42],"Disease":[43],"Activity":[44],"Index)":[45],"were":[46,76,118,144,204],"determined.":[47],"The":[48,152,184,223],"basal":[49,126,200],"serum":[50],"levels":[51,127,143,191,201],"of":[52,84,101,128,155,202,232,242],"cortisol,":[53],"total":[54],"testosterone":[55,58],"(T),":[56],"free":[57],"(FT),":[59],"androstenedione,":[60],"dehydroepiandrosterone":[61],"sulfate":[62],"(DHEAS),":[63],"estradiol":[64],"(E2),":[65],"prolactin":[66],"(PRL),":[67],"luteinizing":[68,91],"hormone":[69,74,92,94],"(LH),":[70],"follicle":[72],"stimulating":[73],"(FSH)":[75],"measured":[77],"all":[79],"individuals.":[80],"In":[81,168],"addition,":[82],"response":[83,100,154,231],"LH":[85,190],"FSH":[87,203],"to":[88,105,170,234],"stimulation":[89,106,158,196,235],"releasing":[93],"(LHRH,":[95],"100":[96],"microg,":[97],"intravenously)":[98],"T":[102,129],"FT":[104,131,156,233],"human":[108],"chorionic":[109],"gonadotropins":[110],"(HCG,":[111],"1500":[112],"u":[113],"intramuscular":[114],"3":[116],"days)":[117],"examined.":[119],"RESULTS:":[120],"Patients":[121],"had":[124,225],"lower":[125,146,178],"than":[132,149,181],"controls":[133],"but":[134,238],"this":[135],"difference":[136],"was":[137,176,217],"not":[138,187],"significant.":[139],"DHEAS":[140],"A":[142],"significantly":[145,177,205],"low":[153],"after":[157,195],"HCG":[160],"indicated":[161],"diminished":[162,226],"testis":[163,224],"function":[164,216],"(mainly":[165],"Leidyg":[166],"cells).":[167],"contrast":[169],"other":[171],"studies,":[172],"E2":[174],"level":[175],"groups":[185],"did":[186],"differ":[188],"at":[192],"baseline":[193],"or":[194],"LHRH.":[198],"However,":[199],"higher":[206],"patients.":[208],"CONCLUSION:":[209],"These":[210],"results":[211],"suggest":[212],"that":[213],"hypothalamic-pituitary-axis":[215],"normal":[218],"SLE.":[222],"function,":[227],"shown":[228],"by":[229],"reduced":[230],"HCG,":[237],"possible":[239],"inhibitory":[240],"effects":[241],"glucocorticoid":[243],"therapy":[244],"must":[245],"be":[246],"considered.":[247]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
