{"id":"https://openalex.org/W2409324014","doi":null,"title":"Risk assessment of human myelotoxicity of anticancer drugs: a predictive model and the in vitro colony forming unit granulocyte/macrophage (CFU-GM) assay.","display_name":"Risk assessment of human myelotoxicity of anticancer drugs: a predictive model and the in vitro colony forming unit granulocyte/macrophage (CFU-GM) assay.","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2409324014","mag":"2409324014","pmid":"https://pubmed.ncbi.nlm.nih.gov/16526561"},"language":"en","primary_location":{"id":"pmid:16526561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16526561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061679683","display_name":"Noriko Masubuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"N Masubuchi","raw_affiliation_strings":["Drug Metabolism and Physicochemistry Research Laboratory, Daiichi, Pharmaceutical Co., Ltd. 16-13 Kita-Kasai 1-Chome Edogawa-ku Tokyo 134-8630, Japan. masub4p6@daiichipharm.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Physicochemistry Research Laboratory, Daiichi, Pharmaceutical Co., Ltd. 16-13 Kita-Kasai 1-Chome Edogawa-ku Tokyo 134-8630, Japan. masub4p6@daiichipharm.co.jp","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061679683"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2246,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.4875979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"61","issue":"2","first_page":"135","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.04699999839067459,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9810000061988831},{"id":"https://openalex.org/keywords/camptothecin-derivatives","display_name":"camptothecin derivatives","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.8799999952316284},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.9240000247955322},{"id":"https://openalex.org/keywords/9-aminocamptothecin","display_name":"9-aminocamptothecin","score":0.972000002861023},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/predictive-toxicology","display_name":"predictive toxicology","score":0.5299999713897705},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.8679068684577942},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7666434049606323},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7443802356719971},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6835814118385315},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6712251901626587},{"id":"https://openalex.org/C2781209748","wikidata":"https://www.wikidata.org/wiki/Q419953","display_name":"Topotecan","level":3,"score":0.6617792248725891},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.48956212401390076},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4436357319355011},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.43994051218032837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4378453493118286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3363325595855713},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2970260977745056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29568296670913696},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2435895800590515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17556166648864746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10931304097175598},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001855","descriptor_name":"Bone Marrow Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:16526561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16526561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107117613","https://openalex.org/W1995743646","https://openalex.org/W2043298989","https://openalex.org/W2312176571","https://openalex.org/W2064527585","https://openalex.org/W2040259461","https://openalex.org/W2232149995","https://openalex.org/W1497855761","https://openalex.org/W2050254443","https://openalex.org/W31822687"],"abstract_inverted_index":{"Myelotoxicity":[0],"is":[1,14,27,142],"one":[2],"of":[3,10,30,41,58,73,117,157,160,196,210],"the":[4,8,31,52,95,130,145,155,163,167,175,182,208],"major":[5],"limitations":[6],"to":[7,16,45,50,93,129],"use":[9],"anticancer":[11,212],"drugs.":[12],"It":[13],"desirable":[15],"evaluate":[17],"human":[18,53,110,132,176],"myelotoxicity":[19,72,116],"before":[20],"a":[21,47,87],"Phase":[22],"I":[23],"study,":[24],"however,":[25],"this":[26,42,187,197],"difficult":[28],"because":[29],"differences":[32],"in":[33,120,146,151,200,207],"susceptibility":[34],"between":[35],"humans":[36,85],"and":[37,68,84,98,105,111,124,150,172],"animals.":[38],"The":[39,71,137,194],"purpose":[40],"study":[43],"was":[44,76],"establish":[46],"reliable":[48],"method":[49],"predict":[51],"maximum":[54],"tolerated":[55],"dose":[56],"(MTD)":[57],"five":[59,183],"camptothecin":[60,69,74,184],"derivatives:":[61],"SN-38,":[62],"DX-8951f,":[63],"topotecan":[64],"(TPT),":[65],"9-aminocamptothecin":[66],"(9-AC),":[67],"(CAM).":[70],"derivatives":[75,185],"evaluated":[77],"on":[78,154],"bone":[79],"marrow":[80],"from":[81],"mice,":[82],"dogs,":[83],"using":[86,109],"14-day":[88],"colony-forming":[89],"unit-granulocyte/macrophage":[90],"(CFU-GM)":[91],"assay":[92,149],"determine":[94],"50%,":[96],"75%,":[97],"90%":[99],"inhibitory":[100],"concentration":[101],"values":[102,114],"(IC50,":[103],"IC75,":[104],"IC90,":[106],"respectively).":[107],"Then,":[108],"murine":[112],"IC90":[113],"for":[115,181,199],"these":[118],"compounds,":[119],"vivo":[121,152],"toxicological":[122],"data,":[123],"pharmacokinetic":[125],"parameters":[126,153],"(data":[127],"referred":[128],"literature),":[131],"MTDs":[133,177],"were":[134,178],"predicted":[135,180],"retrospectively.":[136],"mechanism-based":[138],"prediction":[139],"model":[140,188,198],"which":[141],"proposed":[143],"uses":[144],"vitro":[147,201],"CFU-GM":[148],"basis":[156],"free":[158],"fraction":[159],"area":[161],"under":[162],"concentration-curve":[164],"(AUC)":[165],"at":[166],"MTD":[168],"(r2":[169],"=":[170],"0.887)":[171],"suggests":[173],"that":[174],"well":[179],"by":[186,191],"rather":[189],"than":[190],"other":[192],"models.":[193],"application":[195],"hematotoxicology":[202],"could":[203],"be":[204],"very":[205],"useful":[206],"development":[209],"new":[211],"agents.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
