{"id":"https://openalex.org/W2409199620","doi":null,"title":"Allergen specific immunoglobulins during pregnancy.","display_name":"Allergen specific immunoglobulins during pregnancy.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2409199620","mag":"2409199620"},"language":"en","primary_location":{"id":"pmh:oai:shura.shu.ac.uk:19325","doi":null,"is_oa":true,"landing_page_url":"http://shura.shu.ac.uk/19325/1/10694206.pdf","pdf_url":"http://shura.shu.ac.uk/19325/1/10694206.pdf","source":{"id":"https://openalex.org/S4306401600","display_name":"SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71422933","host_organization_name":"Sheffield Hallam University","host_organization_lineage":["https://openalex.org/I71422933"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://shura.shu.ac.uk/19325/1/10694206.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019217273","display_name":"Utpal Barua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Utpal Barua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019217273"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.796999990940094},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.8209999799728394},{"id":"https://openalex.org/keywords/igg4","display_name":"IgG4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/timothy-grass-pollen","display_name":"timothy grass pollen","score":0.9340000152587891},{"id":"https://openalex.org/keywords/first-trimester-abortion","display_name":"first-trimester abortion","score":0.7609999775886536},{"id":"https://openalex.org/keywords/maternal-allergy","display_name":"maternal allergy","score":0.6200000047683716},{"id":"https://openalex.org/keywords/serum-immunoglobulin-levels","display_name":"serum immunoglobulin levels","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.8591454029083252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8166958093643188},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.7468706369400024},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.6396538019180298},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5848337411880493},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.49054640531539917},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44324642419815063},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.342958927154541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07102617621421814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:shura.shu.ac.uk:19325","doi":null,"is_oa":true,"landing_page_url":"http://shura.shu.ac.uk/19325/1/10694206.pdf","pdf_url":"http://shura.shu.ac.uk/19325/1/10694206.pdf","source":{"id":"https://openalex.org/S4306401600","display_name":"SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71422933","host_organization_name":"Sheffield Hallam University","host_organization_lineage":["https://openalex.org/I71422933"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/591380","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/591380","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:hdl:10068/593131","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/593131","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:2409199620","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/357946","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2525751617","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/332941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:shura.shu.ac.uk:19325","doi":null,"is_oa":true,"landing_page_url":"http://shura.shu.ac.uk/19325/1/10694206.pdf","pdf_url":"http://shura.shu.ac.uk/19325/1/10694206.pdf","source":{"id":"https://openalex.org/S4306401600","display_name":"SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71422933","host_organization_name":"Sheffield Hallam University","host_organization_lineage":["https://openalex.org/I71422933"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2409199620.pdf","grobid_xml":"https://content.openalex.org/works/W2409199620.grobid-xml"},"referenced_works_count":155,"referenced_works":["https://openalex.org/W4585564","https://openalex.org/W41536116","https://openalex.org/W44628373","https://openalex.org/W84007045","https://openalex.org/W137391211","https://openalex.org/W143532817","https://openalex.org/W152056593","https://openalex.org/W163565054","https://openalex.org/W304190930","https://openalex.org/W375044034","https://openalex.org/W1481838430","https://openalex.org/W1530305302","https://openalex.org/W1536259804","https://openalex.org/W1540318921","https://openalex.org/W1554034936","https://openalex.org/W1567233573","https://openalex.org/W1568665194","https://openalex.org/W1571559996","https://openalex.org/W1601830049","https://openalex.org/W1606354783","https://openalex.org/W1625181872","https://openalex.org/W1657740120","https://openalex.org/W1680932833","https://openalex.org/W1912839853","https://openalex.org/W1931351697","https://openalex.org/W1964520555","https://openalex.org/W1966628430","https://openalex.org/W1969827707","https://openalex.org/W1972831560","https://openalex.org/W1973104855","https://openalex.org/W1973678926","https://openalex.org/W1974224445","https://openalex.org/W1976168109","https://openalex.org/W1976736206","https://openalex.org/W1978211572","https://openalex.org/W1978411158","https://openalex.org/W1980204379","https://openalex.org/W1982200418","https://openalex.org/W1987657678","https://openalex.org/W1987778648","https://openalex.org/W1988231921","https://openalex.org/W1988253898","https://openalex.org/W1989619947","https://openalex.org/W1991791073","https://openalex.org/W1992787013","https://openalex.org/W1992984917","https://openalex.org/W1993048215","https://openalex.org/W1993181800","https://openalex.org/W1997808959","https://openalex.org/W1997922548","https://openalex.org/W1998710143","https://openalex.org/W2002837243","https://openalex.org/W2004351423","https://openalex.org/W2009127104","https://openalex.org/W2009437387","https://openalex.org/W2009986041","https://openalex.org/W2010920010","https://openalex.org/W2012213345","https://openalex.org/W2012708666","https://openalex.org/W2014950046","https://openalex.org/W2016585176","https://openalex.org/W2017200961","https://openalex.org/W2017912503","https://openalex.org/W2019944640","https://openalex.org/W2021728568","https://openalex.org/W2022546816","https://openalex.org/W2022708464","https://openalex.org/W2023122744","https://openalex.org/W2025257148","https://openalex.org/W2025296932","https://openalex.org/W2025593994","https://openalex.org/W2025645627","https://openalex.org/W2029305137","https://openalex.org/W2033101704","https://openalex.org/W2034415458","https://openalex.org/W2034925526","https://openalex.org/W2036674363","https://openalex.org/W2037175180","https://openalex.org/W2038811742","https://openalex.org/W2039318775","https://openalex.org/W2041130538","https://openalex.org/W2041845273","https://openalex.org/W2044390886","https://openalex.org/W2045068174","https://openalex.org/W2045659803","https://openalex.org/W2047744017","https://openalex.org/W2050568232","https://openalex.org/W2052846990","https://openalex.org/W2054867101","https://openalex.org/W2059364790","https://openalex.org/W2060128281","https://openalex.org/W2062795290","https://openalex.org/W2062956316","https://openalex.org/W2063610609","https://openalex.org/W2065342543","https://openalex.org/W2066551498","https://openalex.org/W2070001148","https://openalex.org/W2074025808","https://openalex.org/W2079861713","https://openalex.org/W2082726492","https://openalex.org/W2082794327","https://openalex.org/W2083923976","https://openalex.org/W2084794735","https://openalex.org/W2086943230","https://openalex.org/W2088978121","https://openalex.org/W2089842758","https://openalex.org/W2095170663","https://openalex.org/W2100898144","https://openalex.org/W2102824566","https://openalex.org/W2123733931","https://openalex.org/W2128824858","https://openalex.org/W2134674910","https://openalex.org/W2135051950","https://openalex.org/W2137351162","https://openalex.org/W2139350387","https://openalex.org/W2153554554","https://openalex.org/W2157605027","https://openalex.org/W2161752363","https://openalex.org/W2202996231","https://openalex.org/W2231973414","https://openalex.org/W2314570011","https://openalex.org/W2318861253","https://openalex.org/W2319838259","https://openalex.org/W2327878210","https://openalex.org/W2329388211","https://openalex.org/W2335739883","https://openalex.org/W2342112188","https://openalex.org/W2394720977","https://openalex.org/W2395678205","https://openalex.org/W2396442897","https://openalex.org/W2400618816","https://openalex.org/W2401297663","https://openalex.org/W2402923440","https://openalex.org/W2405306094","https://openalex.org/W2405766451","https://openalex.org/W2410503802","https://openalex.org/W2410892587","https://openalex.org/W2411405470","https://openalex.org/W2411918240","https://openalex.org/W2412279696","https://openalex.org/W2414954902","https://openalex.org/W2416737798","https://openalex.org/W2416956871","https://openalex.org/W2418684231","https://openalex.org/W2419106848","https://openalex.org/W2419434584","https://openalex.org/W2419600710","https://openalex.org/W2460317904","https://openalex.org/W2472636316","https://openalex.org/W2475180765","https://openalex.org/W2615977127","https://openalex.org/W2799543564","https://openalex.org/W2896651885","https://openalex.org/W3009548062","https://openalex.org/W4300892348"],"related_works":["https://openalex.org/W2096385235","https://openalex.org/W2185472904","https://openalex.org/W2023120351","https://openalex.org/W2899769653","https://openalex.org/W2096056925","https://openalex.org/W1964221054","https://openalex.org/W4391976501","https://openalex.org/W2754389877","https://openalex.org/W2115916330","https://openalex.org/W2917340244"],"abstract_inverted_index":{"In":[0,191],"this":[1],"study":[2],"the":[3,19,43,61,91,110,135,157,167,193,198,209,212,219,234,256,260,284,292,322,328],"serum":[4,45,62,146,199],"concentration":[5,47,63,147,200,220,240],"of":[6,64,76,122,148,159,177,201,221,233,241,255,281,287],"IgE":[7,150,160,187,203,223],"and":[8,11,27,33,71,103,133,172,195,302,310,325],"IgG4":[9,77,97,123,243],"(total":[10],"allergen":[12],"specific":[13],"taking":[14],"Timothy":[15],"grass":[16],"pollen":[17],"as":[18,81],"model":[20],"allergen)":[21],"have":[22],"been":[23],"investigated":[24],"prospectively":[25],"during":[26,53,106,131,189,228],"after":[28],"pregnancy":[29,132,248],"in":[30,50,60,85,101,109,134,151,165,208,216,247,249,259,271,276,321,327],"healthy":[31],"women":[32,34,70,88,105,114,197,277,331],"suffering":[35],"from":[36],"allergic":[37,69,73,102,113,152,210,217,323],"rhinitis.":[38],"The":[39,239,316],"results":[40,127],"show":[41,128],"that":[42,129],"total":[44,149],"IgG":[46,65],"remained":[48],"unchanged":[49],"both":[51,130,192],"groups":[52],"pregnancy.":[54,190],"There":[55,265],"was":[56,139,161,204,224,244,319],"no":[57],"significant":[58],"difference":[59],"4":[66],"between":[67,299],"pregnant":[68,87,194,330],"non-pregnant":[72,111,136,196,235,261],"women.":[74,315],"Levels":[75],"were":[78,99,306,312],"approximately":[79],"twice":[80],"high":[82],"(p<":[83,143,237,263,332],"0.01)":[84],"non-allergic":[86,92,104,125,154,213],"compared":[89],"to":[90,175,186,267,307,313],"nonpregnant":[93],"control":[94],"group.":[95],"Total":[96],"concentrations":[98],"similar":[100],"pregnancy;":[107],"however,":[108],"state":[112,137],"had":[115],"significantly":[116,142,162,206],"(p":[117],"=":[118],"0.017)":[119],"higher":[120],"levels":[121,188],"than":[124,153,211],"women.The":[126],"there":[138],"a":[140],"highly":[141,205],"0.001)":[144],"greater":[145,207],"subjects.":[155,214],"Although":[156],"level":[158,236,257],"(p=0.004)":[163],"lower":[164,227],"pregnancy,":[166,229],"differences":[168],"are":[169],"relatively":[170],"small":[171],"seem":[173],"unlikely":[174],"be":[176,268],"great":[178],"physiological":[179],"significance.":[180],"Allergic":[181],"symptomatology":[182],"did":[183],"not":[184],"correspond":[185],"antigen-specific":[202,222,242],"However,":[215],"women,":[218],"very":[225],"much":[226],"at":[230,291],"about":[231,253],"6%":[232],"0.001).":[238,264,333],"also":[245],"reduced":[246],"allergy":[250,308],"sufferers,":[251],"being":[252],"half":[254],"found":[258],"individuals":[262],"appeared":[266],"an":[269],"increase":[270],"spontaneous":[272],"first":[273],"trimester":[274],"abortion":[275,317],"who":[278],"suffered":[279],"symptoms":[280],"allergy.":[282],"From":[283],"case":[285],"histories":[286],"all":[288],"418":[289],"pregnancies":[290],"Langold":[293],"Health":[294],"Centre":[295],"ante-natal":[296],"clinic":[297],"attending":[298],"September":[300],"1976":[301],"December":[303],"1990,":[304],"192":[305],"sufferers":[309],"226":[311],"normal":[314,329],"rate":[318],"16.7%":[320],"group":[324],"5.3%":[326]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
