{"id":"https://openalex.org/W2409133809","doi":null,"title":"In vitro myelotoxicity of 2',3'-dideoxynucleosides on human hematopoietic progenitor cells.","display_name":"In vitro myelotoxicity of 2',3'-dideoxynucleosides on human hematopoietic progenitor cells.","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W2409133809","mag":"2409133809","pmid":"https://pubmed.ncbi.nlm.nih.gov/2379548"},"language":"en","primary_location":{"id":"pmid:2379548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2379548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110396195","display_name":"De\u2010Lin Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091357","display_name":"Hipple Cancer Research Center","ror":"https://ror.org/00e4xmg89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210091357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Du","raw_affiliation_strings":["Hipple Cancer Research Center, Dayton, Ohio 45439-2092"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hipple Cancer Research Center, Dayton, Ohio 45439-2092","institution_ids":["https://openalex.org/I4210091357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067664883","display_name":"Donna A. Volpe","orcid":"https://orcid.org/0000-0002-8286-9679","observed_orcids":["https://orcid.org/0000-0002-8286-9679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Volpe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030654482","display_name":"Charles K. Grieshaber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C K Grieshaber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"M J Murphy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5957,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92873622,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"7","first_page":"832","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9190000295639038},{"id":"https://openalex.org/keywords/2-3-dideoxynucleosides","display_name":"2',3'-dideoxynucleosides","score":0.9629999995231628},{"id":"https://openalex.org/keywords/2-3-dideoxyadenosine","display_name":"2',3'-dideoxyadenosine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/2-3-dideoxyinosine","display_name":"2',3'-dideoxyinosine","score":1.0},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.902999997138977},{"id":"https://openalex.org/keywords/bfu-e","display_name":"BFU-E","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cfu-e","display_name":"CFU-E","score":0.996999979019165},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.7519999742507935},{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.8250373005867004},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7907991409301758},{"id":"https://openalex.org/C2777279920","wikidata":"https://www.wikidata.org/wiki/Q2931384","display_name":"CFU-GM","level":4,"score":0.7042542695999146},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5306882858276367},{"id":"https://openalex.org/C192285135","wikidata":"https://www.wikidata.org/wiki/Q954757","display_name":"Colony-forming unit","level":3,"score":0.517011284828186},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48146191239356995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46918821334838867},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.4537700414657593},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4500763714313507},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.418051540851593},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4038001000881195},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40371447801589966},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3639828562736511},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.28573501110076904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12567859888076782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10325208306312561},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05771493911743164},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2379548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2379548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"mag:2409133809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2379548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2012939528","display_name":"IN VITRO ANTINEOPLASTIC DRUG TOXICOLOGY CHARACTERIZATION","funder_award_id":"n44cm077831-000","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041252461","https://openalex.org/W1963848480","https://openalex.org/W2415396987","https://openalex.org/W2008113775","https://openalex.org/W1843999247","https://openalex.org/W2140613041","https://openalex.org/W2021333879","https://openalex.org/W2407540129","https://openalex.org/W359643759","https://openalex.org/W2107511601"],"abstract_inverted_index":{"Three":[0],"nucleoside":[1],"analogues,":[2],"2',3'-dideoxyadenosine":[3],"(ddA),":[4],"2',3'-dideoxyinosine":[5],"(ddI),":[6],"and":[7,29,35,69,85,98,121,138,146,154,159,178],"2',3'-dideoxycytosine":[8],"(ddC),":[9],"were":[10,43,73,100,117,161],"evaluated":[11],"for":[12,48,109],"their":[13],"potential":[14],"myelotoxic":[15,129,163],"effects":[16],"to":[17,45,53,81,96,107,119,125,130,157,164,172,176,187],"normal":[18],"human":[19,82,131,165],"hematopoietic":[20,132,166],"progenitor":[21,41,94],"cells.":[22],"The":[23],"myeloid":[24],"(granulocyte-monocyte":[25],"colony-forming":[26,37],"units,":[27,33,38],"CFU-gm)":[28],"erythroid":[30,36],"(erythroid":[31],"burst-forming":[32],"BFU-e:":[34],"CFU-e)":[39],"committed":[40],"cells":[42],"exposed":[44,61],"the":[46,63],"agents":[47],"a":[49,56,169],"1-h":[50,89,110,153,170],"period":[51],"prior":[52],"culture":[54,65],"in":[55],"microcapillary":[57],"assay":[58],"or":[59,90],"continuously":[60],"during":[62],"entire":[64],"period.":[66],"Both":[67],"ddA":[68,97,120,158,177],"ddI":[70,99,160],"(100":[71,113],"microM)":[72],"mildly":[74],"toxic":[75,186],"(less":[76],"than":[77],"50%":[78],"colony":[79,142],"inhibition)":[80],"CFU-gm,":[83],"BFU-e,":[84],"CFU-e":[86],"following":[87],"either":[88],"continuous":[91,155,181],"exposures.":[92],"Marrow":[93],"sensitivities":[95],"indistinguishable.":[101],"Colony":[102],"inhibition":[103],"ranged":[104],"from":[105],"47%":[106],"67%":[108],"ddC":[111,126,173,182],"exposure":[112,124,171,183],"microM),":[114],"values":[115],"that":[116,152],"comparable":[118],"ddI.":[122],"Continuous":[123],"was":[127,174,184],"highly":[128],"progenitors,":[133],"with":[134],"concentrations":[135],"of":[136],"10":[137],"100":[139],"microM":[140],"suppressing":[141],"formation":[143],"by":[144],"79%-92%":[145],"93%-97%,":[147],"respectively.":[148],"These":[149],"results":[150],"demonstrate":[151],"exposures":[156],"similarly":[162],"cells,":[167],"whereas":[168],"equivalent":[175],"ddI,":[179],"yet":[180],"extremely":[185],"marrow":[188],"cell":[189],"progenitors.":[190]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
