{"id":"https://openalex.org/W2408975187","doi":"https://doi.org/10.11477/mf.1436202965","title":"[Molecular subgrouping and characterization analysis of medulloblastomas in a cohort of Japanese patients].","display_name":"[Molecular subgrouping and characterization analysis of medulloblastomas in a cohort of Japanese patients].","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W2408975187","doi":"https://doi.org/10.11477/mf.1436202965","mag":"2408975187","pmid":"https://pubmed.ncbi.nlm.nih.gov/25672552"},"language":"ja","primary_location":{"id":"pmid:25672552","doi":"https://doi.org/10.11477/mf.1436202965","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25672552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"No shinkei geka. Neurological surgery","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072042064","display_name":"Takafumi Wataya","orcid":"https://orcid.org/0000-0002-1197-5861","observed_orcids":["https://orcid.org/0000-0002-1197-5861"]},"institutions":[{"id":"https://openalex.org/I4210161002","display_name":"Shizuoka Children's Hospital","ror":"https://ror.org/05x23rx38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161002"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Wataya","raw_affiliation_strings":["Department of Neurosurgery, Shizuoka Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shizuoka Children's Hospital","institution_ids":["https://openalex.org/I4210161002"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Minoru Hamasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minoru Hamasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100644772","display_name":"Michael D. Taylor","orcid":"https://orcid.org/0000-0001-7009-3466","observed_orcids":["https://orcid.org/0000-0001-7009-3466","https://orcid.org/0009-0001-7181-1906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael D Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19693451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"2","first_page":"117","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":1.0},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/wnt-subgroup","display_name":"WNT subgroup","score":0.7300000190734863},{"id":"https://openalex.org/keywords/shh-subgroup","display_name":"SHH subgroup","score":0.984000027179718},{"id":"https://openalex.org/keywords/group-3-medulloblastoma","display_name":"Group 3 medulloblastoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/group-4-medulloblastoma","display_name":"Group 4 medulloblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.753000020980835},{"id":"https://openalex.org/keywords/cerebellar-hemispheres","display_name":"cerebellar hemispheres","score":0.8320000171661377},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.5299999713897705},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.9591284990310669},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6016982197761536},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.579947829246521},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5486375689506531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5466904044151306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4962928891181946},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35574451088905334}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057089","descriptor_name":"Pathology, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25672552","doi":"https://doi.org/10.11477/mf.1436202965","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25672552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"No shinkei geka. Neurological surgery","raw_type":"English Abstract"},{"id":"mag:2408975187","doi":"https://doi.org/10.11477/mf.1436202965","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25672552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2326316618","https://openalex.org/W4232086884","https://openalex.org/W4404237192","https://openalex.org/W2618958001","https://openalex.org/W2329510863","https://openalex.org/W2118124054","https://openalex.org/W6983829417","https://openalex.org/W7134925918","https://openalex.org/W2588363929","https://openalex.org/W2619997683"],"abstract_inverted_index":{"Medulloblastoma":[0,24],"is":[1,256,261],"the":[2,52,72,106,110,115,120,127,142,146,149,169,184,190,208,219,233,269],"most":[3],"common":[4],"solid":[5],"malignancy":[6],"and":[7,56,95,124,159,259],"cause":[8],"of":[9,59,62,75,78,105,109,114,119,126,133,148,179,183,207,213,225,235,246,252,272],"oncologic":[10],"death":[11],"among":[12],"children.":[13],"Recent":[14],"advances":[15],"in":[16,80,141,174,189,205,218,254,274],"genomic":[17],"analysis":[18,74,250],"obtained":[19],"through":[20],"international":[21],"large-scale":[22],"collaborations,":[23],"Advanced":[25],"Genomics":[26],"International":[27],"Consortium(MAGIC),":[28],"have":[29],"revealed":[30],"that":[31,51,103,197],"medulloblastomas":[32,63,107,137,182,214,253,273],"can":[33],"be":[34,216],"classified":[35],"into":[36],"at":[37],"least":[38],"four":[39],"distinct":[40],"subgroups":[41,61,77,85],"depending":[42],"on":[43],"their":[44],"molecular":[45,57,76,241,249,270],"expression":[46],"profiles.":[47],"These":[48],"studies":[49],"showed":[50],"prognosis,":[53,226],"age":[54,91,155],"distributions,":[55,92],"mechanisms":[58],"these":[60],"completely":[64],"differ":[65],"from":[66],"each":[67,163],"other.":[68],"Here":[69],"we":[70],"report":[71],"first":[73],"medulloblastoma":[79,200],"Japanese":[81],"patients(Shizuoka":[82],"cohort).":[83],"Molecular":[84,211],"were":[86,98,108,165,202],"predicted":[87,102],"for":[88,162,223,229],"18":[89],"medulloblastomas;and":[90],"radiographic":[93],"features,":[94],"histological":[96],"characteristics":[97],"analyzed.":[99],"It":[100],"was":[101,138,152],"11%":[104],"WNT":[111],"type,":[112,117,123],"50%":[113],"SHH":[116,150,185,209],"6%":[118],"group":[121,128,134,164],"3":[122,135],"33%":[125],"4":[129],"type.":[130,210],"The":[131,193,244],"percentage":[132,147],"type":[136,151,186],"smaller":[139],"than":[140],"MAGIC":[143,170],"study,":[144,177],"while":[145],"larger.":[153],"However,":[154],"distribution,":[156],"recurrence-free":[157],"survival,":[158],"overall":[160],"survival":[161],"quite":[166],"similar":[167],"to":[168],"study.":[171],"In":[172],"addition,":[173],"an":[175],"imaging":[176],"78%":[178],"patients":[180],"with":[181],"presented":[187],"tumors":[188,206],"cerebellar":[191],"hemispheres.":[192],"classical":[194],"pathohistological":[195],"hallmarks":[196],"may":[198],"predict":[199],"prognosis":[201],"mainly":[203],"seen":[204],"subgrouping":[212],"could":[215],"important":[217],"future,":[220],"not":[221],"only":[222],"prediction":[224],"but":[227],"also":[228],"decision":[230],"making":[231],"regarding":[232],"use":[234],"future":[236],"new":[237],"treatments":[238],"such":[239],"as":[240],"targeting":[242],"therapy.":[243],"establishment":[245],"a":[247],"public":[248],"system":[251],"Japan":[255],"greatly":[257],"desired,":[258],"it":[260],"currently":[262],"under":[263],"development;this":[264],"database":[265],"will":[266],"help":[267],"establish":[268],"diagnosis":[271],"Japan.":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}