{"id":"https://openalex.org/W2408921920","doi":null,"title":"Production of granulocyte/macrophage colony-stimulating factor in human airways during allergen-induced late-phase reactions in atopic subjects.","display_name":"Production of granulocyte/macrophage colony-stimulating factor in human airways during allergen-induced late-phase reactions in atopic subjects.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W2408921920","mag":"2408921920","pmid":"https://pubmed.ncbi.nlm.nih.gov/1477181"},"language":"en","primary_location":{"id":"pmid:1477181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1477181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lymphokine and cytokine research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046666804","display_name":"Masaya Kato","orcid":"https://orcid.org/0000-0002-8863-8775","observed_orcids":["https://orcid.org/0000-0002-8863-8775"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Kato","raw_affiliation_strings":["Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044688547","display_name":"M.C. Liu","orcid":"https://orcid.org/0000-0003-3232-8732","observed_orcids":["https://orcid.org/0000-0003-3232-8732"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Liu","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029619543","display_name":"Becky A. Stealey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B A Stealey","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025967136","display_name":"B. Friedman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Friedman","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111846072","display_name":"Lawrence M. Lichtenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Lichtenstein","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113602044","display_name":"Solbert Permutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Permutt","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109881458","display_name":"Robert P. Schleimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R P Schleimer","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.6266,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.73331224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"11","issue":"6","first_page":"287","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/late-phase-allergic-reaction","display_name":"late-phase allergic reaction","score":0.8180000185966492},{"id":"https://openalex.org/keywords/allergen-challenge","display_name":"allergen challenge","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8659999966621399},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.800000011920929},{"id":"https://openalex.org/keywords/cytokine-activity","display_name":"cytokine activity","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7500544786453247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6967111229896545},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6622231006622314},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.5619492530822754},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.5270246267318726},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.4248579740524292},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3997153043746948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3986510634422302},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.3119702935218811},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.296586811542511},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.253139853477478}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1477181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1477181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lymphokine and cytokine research","raw_type":"Journal Article"},{"id":"mag:2408921920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1477181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1601089559","https://openalex.org/W2430676660","https://openalex.org/W2087510566","https://openalex.org/W2034050426","https://openalex.org/W1908107679","https://openalex.org/W2089257031","https://openalex.org/W1963606005","https://openalex.org/W2012829998","https://openalex.org/W2165854800","https://openalex.org/W2019066740"],"abstract_inverted_index":{"Granulocyte-macrophage":[0],"colony-stimulating":[1],"factor":[2],"(GM-CSF)":[3],"and":[4,18,23,50,110,178,193,214],"interleukin-3":[5],"(IL-3)":[6],"are":[7],"hematopoietic":[8],"growth":[9],"factors":[10],"that":[11,181],"have":[12],"been":[13],"shown":[14],"to":[15,130,155],"induce":[16],"proliferation":[17],"activation":[19],"of":[20,38,48,101,137,184,208,217],"inflammatory":[21],"cells,":[22],"may":[24],"play":[25],"a":[26,171],"role":[27],"in":[28,40,43,54,60,70,144,196,210,219],"allergic":[29,41,72],"reactions.":[30],"Since":[31],"little":[32],"is":[33,128],"known":[34],"about":[35],"the":[36,44,46,61,102,120,182,185,206,215],"involvement":[37],"cytokines":[39],"inflammation":[42],"lung,":[45],"levels":[47],"GM-CSF":[49,132,177,203,209],"IL-3":[51,179],"were":[52,94,107,117],"measured":[53],"bronchoalveolar":[55],"lavage":[56],"(BAL)":[57],"fluids":[58,81,106,190],"obtained":[59],"late":[62],"phase":[63],"after":[64,83],"segmental":[65],"lung":[66],"antigen":[67],"(Ag)":[68],"challenge":[69,93,157],"14":[71,103],"rhinitis":[73],"subjects":[74],"with":[75],"or":[76,88,90,133],"without":[77],"bronchial":[78],"asthma.":[79],"BAL":[80,105,189,212,220],"either":[82,131],"Ag":[84],"(ragweed,":[85],"dust":[86],"mite,":[87],"timothy)":[89],"saline":[91,156],"control":[92],"recovered":[95],"19":[96],"h":[97],"later.":[98],"In":[99],"6":[100],"patients,":[104],"concentration-dialyzed":[108],"(20x)":[109],"assayed":[111],"for":[112],"cytokine":[113],"activity.":[114,204],"Cytokine":[115],"assays":[116],"performed":[118],"using":[119,170],"human":[121],"megakaryocytic":[122],"leukemic":[123],"cell":[124],"line":[125],"M-07e,":[126],"which":[127],"responsive":[129],"IL-3.":[134],"The":[135],"level":[136,207],"GM-CSF-equivalents":[138],"was":[139,187],"approximately":[140],"25":[141],"times":[142],"higher":[143],"Ag-challenged":[145,211],"sites":[146,158,195],"(49.9":[147],"+/-":[148,152,160],"12.7":[149],"pg/ml;":[150],"mean":[151],"SEM),":[153],"compared":[154],"(2.2":[159],"1.0,":[161],"p":[162,229],"<":[163,230],"0.01,":[164],"n":[165,232],"=":[166,227,233],"9).":[167],"Neutralization":[168],"experiments":[169],"polyclonal":[172],"specific":[173],"antibody":[174],"(Ab)":[175],"against":[176],"revealed":[180],"bulk":[183],"activity":[186],"GM-CSF.":[188],"from":[191,221],"Ag-":[192],"saline-challenged":[194],"one":[197],"nonatopic":[198],"subject":[199,223],"contained":[200],"no":[201],"significant":[202],"Furthermore,":[205],"fluid":[213],"percentage":[216],"eosinophils":[218],"each":[222],"correlated":[224],"significantly":[225],"(r":[226],"0.73,":[228],"0.005,":[231],"14).(ABSTRACT":[234],"TRUNCATED":[235],"AT":[236],"250":[237],"WORDS)":[238]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}