{"id":"https://openalex.org/W2408898441","doi":"https://doi.org/10.1055/s-0038-1665405","title":"Levels of Prothrombin Fragment F1+2 in Patients with Hyperhomocysteinemia and a History of Venous Thromboembolism","display_name":"Levels of Prothrombin Fragment F1+2 in Patients with Hyperhomocysteinemia and a History of Venous Thromboembolism","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2408898441","doi":"https://doi.org/10.1055/s-0038-1665405","mag":"2408898441","pmid":"https://pubmed.ncbi.nlm.nih.gov/9408013"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1665405","doi":"https://doi.org/10.1055/s-0038-1665405","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1665405","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060041875","display_name":"Paul Alexander Kyrle","orcid":"https://orcid.org/0000-0002-8813-8228","observed_orcids":["https://orcid.org/0000-0002-8813-8228"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Paul A Kyrle","raw_affiliation_strings":["The Department of Internal Medicine I, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine I, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067725288","display_name":"A St\u00fcmpflen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas St\u00fcmpflen","raw_affiliation_strings":["The Department of Internal Medicine II, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine II, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060584054","display_name":"Mirko Hirschl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210101126","display_name":"Hanusch Hospital","ror":"https://ror.org/0163qhr63","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210101126"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Mirko Hirschl","raw_affiliation_strings":["The Department of Hanuschkrankenhaus, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Hanuschkrankenhaus, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210101126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008309350","display_name":"Christine Bialonczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210093545","display_name":"Wilhelminen Hospital","ror":"https://ror.org/00qcsrr17","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210093545","https://openalex.org/I4210117134"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christine Bialonczyk","raw_affiliation_strings":["The Department of Wilhelminenspital, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Wilhelminenspital, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210093545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108380214","display_name":"Kurt R Herkner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Kurt Herkner","raw_affiliation_strings":["The Children's Hospital, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112019613","display_name":"Wolfgang Speiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Wolfgang Speiser","raw_affiliation_strings":["The Clinical Institute of Medical and Chemical Laboratory Diagnostic, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Institute of Medical and Chemical Laboratory Diagnostic, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110862720","display_name":"Ansgar Weltermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ansgar Weltermann","raw_affiliation_strings":["The Department of Internal Medicine I, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine I, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080975285","display_name":"Alexandra Kaider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Alexandra Kaider","raw_affiliation_strings":["The Department of Medical Computer Sciences, Section of Clinical Biometrics, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Medical Computer Sciences, Section of Clinical Biometrics, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008303162","display_name":"Ingrid Pabinger","orcid":"https://orcid.org/0000-0002-7677-9896","observed_orcids":["https://orcid.org/0000-0002-7677-9896"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ingrid Pabinger","raw_affiliation_strings":["The Department of Internal Medicine I, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine I, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107845763","display_name":"Klaus Lechner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Klaus Lechner","raw_affiliation_strings":["The Department of Internal Medicine I, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine I, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053093013","display_name":"Sabine Eichinger","orcid":"https://orcid.org/0000-0003-1135-4878","observed_orcids":["https://orcid.org/0000-0003-1135-4878"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sabine Eichinger","raw_affiliation_strings":["The Department of Internal Medicine I, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Internal Medicine I, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.686,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.90225933,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"78","issue":"05","first_page":"1327","last_page":"1331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prothrombin-fragment-1-2","display_name":"prothrombin fragment 1+2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":1.0},{"id":"https://openalex.org/keywords/thrombin-generation","display_name":"thrombin generation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oral-anticoagulants","display_name":"oral anticoagulants","score":0.875},{"id":"https://openalex.org/keywords/recurrent-venous-thromboembolism","display_name":"recurrent venous thromboembolism","score":0.9419999718666077},{"id":"https://openalex.org/keywords/thrombosis-risk-factors","display_name":"thrombosis risk factors","score":0.6880000233650208},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.5490000247955322},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8608419895172119},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7586814165115356},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.7509692907333374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7149340510368347},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6911933422088623},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5398591756820679},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.5308884978294373},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.5022940635681152},{"id":"https://openalex.org/C3018972837","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin generation","level":4,"score":0.47583818435668945},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.4316372871398926},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3646792471408844},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36360257863998413},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.328069269657135},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.2437213659286499},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.21091511845588684}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006487","descriptor_name":"Hemostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0038-1665405","doi":"https://doi.org/10.1055/s-0038-1665405","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1665405","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:9408013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9408013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987898914","https://openalex.org/W2065877278","https://openalex.org/W2084332086","https://openalex.org/W2060310184","https://openalex.org/W7150998032","https://openalex.org/W2328530159","https://openalex.org/W1918125325","https://openalex.org/W2012424580","https://openalex.org/W1998940372","https://openalex.org/W135891373"],"abstract_inverted_index":{"Increased":[0],"thrombin":[1,92],"generation":[2,93],"occurs":[3],"in":[4,10,22,84,226,248,281],"many":[5],"individuals":[6],"with":[7,24,47,105,112,164,188,234,253,266,283],"inherited":[8],"defects":[9],"the":[11,85,162,186,193,202,227],"antithrombin":[12],"or":[13,213],"protein":[14],"C":[15],"anticoagulant":[16,259],"pathways":[17],"and":[18,57,95,146,150,166,180,190,235],"is":[19,33,246],"also":[20],"seen":[21,231],"patients":[23,46,59,111,120,163,187,194,233,252,282],"thrombosis":[25],"without":[26,68,121,170,195,236],"a":[27,71,89,177,241,249],"defined":[28],"clotting":[29],"abnormality.":[30],"Hyperhomocysteinemia":[31],"(H-HC)":[32],"an":[34],"important":[35],"risk":[36],"factor":[37],"of":[38,73,91,102,155,161,185,192,205,251,257,269],"venous":[39],"thromboembolism":[40],"(VTE).":[41],"We":[42,238],"prospectively":[43],"followed":[44,218],"48":[45],"H-HC":[48,69,113,122,165,171,189,196,254],"(median":[49,60],"age":[50,61],"62":[51],"years,":[52,63],"range":[53,64,130,139],"26-83;":[54],"18":[55],"males)":[56,67],"183":[58],"50":[62],"18-85;":[65],"83":[66],"for":[70],"period":[72],"up":[74,158],"to":[75,159,168,276],"one":[76],"year.":[77],"Prothrombin":[78],"fragment":[79],"F1+2":[80,117,174,199,216,228],"(F1+2)":[81],"was":[82,230],"determined":[83],"patient's":[86],"plasma":[87],"as":[88],"measure":[90],"during":[94],"at":[96,208,210],"several":[97],"time":[98],"points":[99],"after":[100,153,255],"discontinuation":[101,154,256],"secondary":[103,264],"thromboprophylaxis":[104,265],"oral":[106,156,258,270],"anticoagulants.":[107],"While":[108],"on":[109],"anticoagulants,":[110,157],"had":[114,172,197],"significantly":[115],"higher":[116,173],"levels":[118,175,200,229],"than":[119,176],"(mean":[123],"0.52":[124],"+/-":[125,134],"0.49":[126],"nmol/l,":[127,136],"median":[128,137],"0.4,":[129],"0.2-2.8,":[131],"versus":[132],"0.36":[133],"0.2":[135],"0.3,":[138],"0.1-2.1;":[140],"p":[141],"=":[142],"0.02).":[143],"Three":[144],"weeks":[145],"3,":[147],"6,":[148],"9":[149],"12":[151],"months":[152],"20%":[160],"5":[167],"6%":[169],"corresponding":[178],"age-":[179],"sex-matched":[181],"control":[182],"group.":[183],"16%":[184],"4%":[191],"either":[198],"above":[201],"upper":[203],"limit":[204],"normal":[206],"controls":[207],"least":[209],"2":[211],"occasions":[212],"(an)":[214],"elevated":[215],"level(s)":[217],"by":[219],"recurrent":[220],"VTE.":[221,262],"No":[222],"statistical":[223],"significant":[224],"difference":[225],"between":[232],"H-HC.":[237,284],"conclude":[239],"that":[240],"permanent":[242],"hemostatic":[243,278],"system":[244,279],"activation":[245,280],"detectable":[247],"proportion":[250],"therapy":[260],"following":[261],"Furthermore,":[263],"conventional":[267],"doses":[268],"anticoagulants":[271],"may":[272],"not":[273],"be":[274],"sufficient":[275],"suppress":[277]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}