{"id":"https://openalex.org/W2408880960","doi":null,"title":"Immune mechanisms against canine distemper. II. Role of antibody in antigen modulation and prevention of intercellular and extracellular spread of canine distemper virus.","display_name":"Immune mechanisms against canine distemper. II. Role of antibody in antigen modulation and prevention of intercellular and extracellular spread of canine distemper virus.","publication_year":1979,"publication_date":"1979-12-01","ids":{"openalex":"https://openalex.org/W2408880960","mag":"2408880960","pmid":"https://pubmed.ncbi.nlm.nih.gov/118114","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1457876"},"language":"en","primary_location":{"id":"pmid:118114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/118114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C K Ho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C K Ho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079330921","display_name":"Lorne A. Babiuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Babiuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.28396059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"38","issue":"4","first_page":"765","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11780","display_name":"Rabies epidemiology and control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-distemper-virus","display_name":"canine distemper virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antibody-neutralization","display_name":"antibody neutralization","score":0.7649999856948853},{"id":"https://openalex.org/keywords/antigen-modulation","display_name":"antigen modulation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cytopathic-effect-inhibition","display_name":"cytopathic effect inhibition","score":0.7250000238418579},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2776040883","wikidata":"https://www.wikidata.org/wiki/Q601037","display_name":"Canine distemper","level":3,"score":0.9752888679504395},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7505170106887817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7158600687980652},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.706531822681427},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6877426505088806},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6423029899597168},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5906191468238831},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5618309378623962},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.5547003746032715},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5541478991508484},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.47185608744621277},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.44792884588241577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2854871153831482},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.24114647507667542},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09811270236968994}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004216","descriptor_name":"Distemper","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004216","descriptor_name":"Distemper","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004217","descriptor_name":"Distemper Virus, Canine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:118114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/118114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:2408880960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/118114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W9446994","https://openalex.org/W1523441186","https://openalex.org/W1656157318","https://openalex.org/W1978903086","https://openalex.org/W2000393599","https://openalex.org/W2054899464","https://openalex.org/W2078315929","https://openalex.org/W2150538289","https://openalex.org/W2168929902","https://openalex.org/W2397440942","https://openalex.org/W2405638372","https://openalex.org/W2412862462","https://openalex.org/W2415711120","https://openalex.org/W2415871489"],"related_works":["https://openalex.org/W4406864567","https://openalex.org/W1761015347","https://openalex.org/W2138369560","https://openalex.org/W3187408483","https://openalex.org/W7123281306","https://openalex.org/W2042978450","https://openalex.org/W2272006561","https://openalex.org/W4411730513","https://openalex.org/W2035395769","https://openalex.org/W2264505005"],"abstract_inverted_index":{"Specific":[0],"antibody":[1,30,76,125,141,155],"was":[2,72,77,99],"shown":[3],"to":[4,58,121,127],"be":[5,53],"highly":[6],"effective":[7],"in":[8,46,101,113,142,158],"neutralizing":[9],"extracellular":[10,37],"canine":[11,106],"distemper":[12],"virus":[13,70],"(CDV)":[14],"as":[15,17,90,92],"well":[16],"preventing":[18],"the":[19,40,61,84,143,151],"intercellular":[20],"spread":[21,71],"of":[22,29,36,42,60,67,86,117,124,129,140],"this":[23],"virus.":[24],"Thus,":[25],"relatively":[26],"low":[27],"levels":[28],"neutralized":[31],"1":[32],"x":[33],"10(5)":[34],"TCID50":[35],"CDV":[38,112,149],"and":[39,48,69,133,150],"development":[41],"plaques":[43],"or":[44],"CPE":[45,68,87],"Hep-2":[47],"Vero":[49],"cells":[50,62,108,120],"respectively":[51],"could":[52,81],"prevented":[54],"even":[55],"when":[56,75],"up":[57],"5%":[59],"were":[63],"infected.":[64],"This":[65,96],"inhibition":[66],"most":[73],"pronounced":[74],"added":[78,89],"early":[79],"but":[80],"still":[82],"limit":[83],"degree":[85],"if":[88],"late":[91],"48":[93],"h":[94],"post-infection.":[95],"anti-viral":[97],"activity":[98],"observed":[100],"different":[102],"cell":[103],"types":[104],"including":[105],"macrophages,":[107],"normally":[109],"infected":[110,118],"with":[111],"vivo.":[114],"Prolonged":[115],"exposure":[116],"target":[119],"high":[122],"concentrations":[123],"led":[126],"redistribution":[128],"surface":[130],"viral":[131],"antigens":[132],"their":[134],"subsequent":[135],"disappearance.":[136],"The":[137],"possible":[138],"role":[139],"defence":[144],"against,":[145],"and/or":[146],"recovery":[147,159],"from":[148],"mechanism(s)":[152],"by":[153],"which":[154],"may":[156],"aid":[157],"are":[160],"discussed.":[161]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}