{"id":"https://openalex.org/W2408856290","doi":"https://doi.org/10.5754/hge12404","title":"Hepatogastroenterology","display_name":"Hepatogastroenterology","publication_year":2012,"publication_date":"2012-06-22","ids":{"openalex":"https://openalex.org/W2408856290","doi":"https://doi.org/10.5754/hge12404","mag":"2408856290","pmid":"https://pubmed.ncbi.nlm.nih.gov/22709823"},"language":"en","primary_location":{"id":"doi:10.5754/hge12404","doi":"https://doi.org/10.5754/hge12404","is_oa":false,"landing_page_url":"http://doi.org/10.5754/hge12404","pdf_url":null,"source":{"id":"https://openalex.org/S57276277","display_name":"Hepatogastroenterology","issn_l":"0172-6390","issn":["0172-6390"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"journal"},"parent_works":[],"lineage":["https://openalex.org/W2408856290"],"child_works_count":0,"type":"paratext","is_traditional":false,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078761894","display_name":"Ximing Xu","orcid":"https://orcid.org/0000-0001-7094-0514","observed_orcids":["https://orcid.org/0000-0001-7094-0514"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi-Ming Xu","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112145934","display_name":"Guangjin Yuan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-Jin Yuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101796191","display_name":"Qianwen Li","orcid":"https://orcid.org/0009-0007-0273-5659","observed_orcids":["https://orcid.org/0009-0007-0273-5659","https://orcid.org/0009-0009-8483-6318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian-Wen Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110393208","display_name":"Shun-Lin Shan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shun-Lin Shan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112596495","display_name":"Shen Jiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shen Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1836,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"119","first_page":"2059","last_page":"63"},"is_retracted":false,"is_paratext":true,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.2442999929189682,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9909999966621399},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.7540000081062317},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":1.0},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7730000019073486},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6850000023841858},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.9093618392944336},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7670289278030396},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7112530469894409},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.6353549957275391},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5479772090911865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5366406440734863},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5092736482620239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47515010833740234},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4525146782398224},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4473171830177307},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4369908571243286},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35550370812416077},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32916343212127686},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32581061124801636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2703232765197754},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24322620034217834},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.22116729617118835},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1990787386894226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06866803765296936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04949212074279785},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071250","descriptor_name":"Snail Family Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.5754/hge12404","doi":"https://doi.org/10.5754/hge12404","is_oa":false,"landing_page_url":"http://doi.org/10.5754/hge12404","pdf_url":null,"source":{"id":"https://openalex.org/S57276277","display_name":"Hepatogastroenterology","issn_l":"0172-6390","issn":["0172-6390"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"journal"},{"id":"pmid:22709823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22709823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2505748120","https://openalex.org/W2331261979","https://openalex.org/W2017467444","https://openalex.org/W2005604684","https://openalex.org/W2160213547","https://openalex.org/W2138234499","https://openalex.org/W4283770754","https://openalex.org/W7144124649","https://openalex.org/W3165977449","https://openalex.org/W6997957840"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"EMT":[1,28,93,176],"plays":[2],"an":[3],"essential":[4],"role":[5],"in":[6,94,177,190],"tumor":[7,195],"progression":[8],"and":[9,40,47,64,73,83,103,112,156,193],"metastasis.":[10,196],"Hyperthermia":[11,172],"is":[12,32],"a":[13],"potent":[14],"approach":[15],"for":[16,44,54],"cancers":[17],"with":[18,38,80,140],"low":[19],"side":[20],"effects.":[21],"However,":[22,143],"the":[23,107,113,125,131,149,154,185],"effect":[24],"of":[25,29,62,76,109,115,120,127,151,159,187],"hyperthermia":[26,51,169,182],"on":[27],"cancer":[30,191],"cells":[31,192],"unknown.":[33],"METHODOLOGY:":[34],"Cells":[35],"were":[36,66,78,146,164],"treated":[37],"TGF-\u03b21":[39,91,163],"epidermal":[41],"growth":[42],"factor":[43],"96":[45],"h":[46],"then":[48],"exposed":[49],"to":[50],"at":[52],"43\u00b0C":[53],"0.5":[55],"h.":[56],"Cell":[57,85],"morphology":[58],"was":[59,88,98,122,134],"observed.":[60],"Expressions":[61],"E-cadherin":[63,121],"vimentin":[65,128],"determined":[67],"by":[68,100,136,148,162,168],"Western":[69,81],"blot.":[70],"The":[71,118],"protein":[72,155],"mRNA":[74,157],"expressions":[75,158],"Snail":[77,160],"detected":[79],"blot":[82],"RT-PCR.":[84],"migratory":[86,132],"capacity":[87],"evaluated.":[89],"RESULTS:":[90],"induced":[92,161],"HepG2":[95,178],"cells,":[96,179],"which":[97],"evidenced":[99],"morphological,":[101],"molecular":[102],"functional":[104],"changes,":[105],"including":[106],"formation":[108],"spindle":[110],"shape":[111],"loss":[114],"cell":[116],"contact.":[117],"expression":[119,126],"decreased":[123],"but":[124],"increased;":[129],"also,":[130],"capability":[133],"increased":[135],"2.1\u00b10.19-fold":[137],"as":[138],"compared":[139],"untreated":[141],"cells.":[142],"those":[144],"effects":[145],"inhibited":[147,167],"treatment":[150,170],"hyperthermia.":[152],"Furthermore,":[153],"also":[165],"significantly":[166],"CONCLUSIONS:":[171],"can":[173],"inhibit":[174,194],"TGF-\u03b21-induced":[175],"suggesting":[180],"that":[181],"may":[183],"alter":[184],"properties":[186],"metastatic":[188],"potential":[189]},"counts_by_year":[{"year":2024,"cited_by_count":73},{"year":2023,"cited_by_count":58},{"year":2022,"cited_by_count":76},{"year":2021,"cited_by_count":127},{"year":2020,"cited_by_count":62},{"year":2019,"cited_by_count":64},{"year":2018,"cited_by_count":70},{"year":2017,"cited_by_count":101},{"year":2016,"cited_by_count":92},{"year":2015,"cited_by_count":99},{"year":2014,"cited_by_count":107},{"year":2013,"cited_by_count":90},{"year":2012,"cited_by_count":93}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}