{"id":"https://openalex.org/W2408767944","doi":null,"title":"From gene therapy to virotherapy for ovarian cancer.","display_name":"From gene therapy to virotherapy for ovarian cancer.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2408767944","mag":"2408767944","pmid":"https://pubmed.ncbi.nlm.nih.gov/15729203"},"language":"en","primary_location":{"id":"pmid:15729203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15729203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva ginecologica","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109081532","display_name":"Mariam A. Stoff\u2010Khalili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Stoff-Khalili","raw_affiliation_strings":["Division of Human Gene Therapy, Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Gene Therapy, Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010794657","display_name":"Peter Dall","orcid":"https://orcid.org/0000-0002-0565-7840","observed_orcids":["https://orcid.org/0000-0002-0565-7840"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Dall","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D T Curiel","raw_affiliation_strings":["Radiation Oncology-Cancer Biol"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology-Cancer Biol","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6612,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6922352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"56","issue":"6","first_page":"503","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/virotherapy","display_name":"virotherapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oncolytic-viruses","display_name":"oncolytic viruses","score":0.8109999895095825},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.7540000081062317},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.746999979019165},{"id":"https://openalex.org/keywords/non-viral-vectors","display_name":"non-viral vectors","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.9001413583755493},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8382545709609985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7516785860061646},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6754945516586304},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.6454427242279053},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5094686150550842},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4973504841327667},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4569559097290039},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4452442526817322},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.43990761041641235},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4369286894798279},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35461705923080444},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3298705220222473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29679936170578003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26904475688934326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15142038464546204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07001596689224243},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15729203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15729203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva ginecologica","raw_type":"Comparative Study"},{"id":"mag:2408767944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15729203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4311721979","display_name":"Enhanced CRAd for Pancreatic Cancer","funder_award_id":"R01CA094084","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6751111239","display_name":"Replicative adenoviruses with enhanced infectivity","funder_award_id":"R01CA083821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8627455277","display_name":"Canine model for evaluating CRAD efficacy","funder_award_id":"R01CA093796","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8991414159","display_name":"SPORE IN OVARIAN CANCER","funder_award_id":"P50CA083591","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010441567","https://openalex.org/W2060752753","https://openalex.org/W2810425480","https://openalex.org/W2038131044","https://openalex.org/W2411207062","https://openalex.org/W2314932979","https://openalex.org/W2496446849","https://openalex.org/W2366070813","https://openalex.org/W2085253081","https://openalex.org/W2314016215"],"abstract_inverted_index":{"Ovarian":[0],"cancer":[1,36,107,163],"has":[2,23,157],"the":[3,10,26,60,64,81,99,118,134,137,152,190,195,201,214],"highest":[4],"mortality":[5],"of":[6,9,63,67,83,101,104,154,188,203,216],"all":[7],"cancers":[8],"female":[11],"reproductive":[12],"system.":[13],"Although":[14],"progress":[15],"in":[16,130,161,179,183],"conventional":[17],"therapies":[18],"(surgery,":[19],"chemotherapy":[20],"and":[21,93,206],"irradiation)":[22],"been":[24,141],"achieved,":[25],"5-year":[27],"survival":[28],"rate":[29],"for":[30,51,80,213],"patients":[31],"with":[32,113,123],"advanced":[33],"stage":[34],"ovarian":[35,68,84,106,162,180,217],"is":[37,44,48,75,128,194],"still":[38],"low.":[39],"On":[40],"this":[41,71,144,184],"basis":[42],"it":[43],"clear":[45],"that":[46,136,151],"there":[47],"a":[49,76,170],"need":[50],"novel":[52,77,209],"therapeutic":[53,211],"paradigms.":[54],"Targeted":[55],"approaches":[56,212],"are":[57],"based":[58],"on":[59],"increasing":[61],"knowledge":[62],"molecular":[65],"basics":[66],"cancer.":[69,85,181,218],"In":[70,143,165],"regard,":[72,145],"gene":[73,88,125,204],"therapy":[74,89,126,205],"targeted":[78,210],"approach":[79,153,187],"treatment":[82,215],"However,":[86],"current":[87,124],"delivery":[90,112],"systems":[91],"(viral":[92],"non-viral":[94],"vectors)":[95],"have":[96,140,149],"to":[97,133,159,172],"address":[98],"issues":[100],"inefficient":[102],"transduction":[103,121],"target":[105],"cells":[108],"and/or":[109],"ectopic":[110],"non-target":[111],"attendant":[114],"toxicity.":[115],"Of":[116],"note,":[117],"limited":[119],"tumor":[120,175],"associated":[122],"interventions":[127],"due,":[129],"large":[131],"part,":[132],"fact":[135],"employed":[138],"vectors":[139,156],"replication-incompetent.":[142],"human":[146],"clinical":[147],"trials":[148],"shown":[150],"replication-incompetent":[155],"yet":[158],"succeed":[160],"patients.":[164],"contrast,":[166],"replication-competent":[167],"viruses":[168],"offer":[169],"method":[171],"achieve":[173],"efficient":[174],"cell":[176],"oncolysis":[177],"(virotherapy)":[178],"Thus,":[182],"very":[185],"promising":[186],"virotherapy":[189,207],"replicating":[191],"virus":[192],"itself":[193],"anti-cancer":[196],"agent.":[197],"This":[198],"review":[199],"discusses":[200],"concepts":[202],"as":[208]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}