{"id":"https://openalex.org/W2408709077","doi":"https://doi.org/10.1152/ajplung.1997.272.4.l779","title":"Involvement of NF-kappaB in silica-induced cyclooxygenase II gene expression in rat alveolar macrophages","display_name":"Involvement of NF-kappaB in silica-induced cyclooxygenase II gene expression in rat alveolar macrophages","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2408709077","doi":"https://doi.org/10.1152/ajplung.1997.272.4.l779","mag":"2408709077","pmid":"https://pubmed.ncbi.nlm.nih.gov/9142954"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.1997.272.4.l779","doi":"https://doi.org/10.1152/ajplung.1997.272.4.l779","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1997.272.4.l779","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"F. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Chen","raw_affiliation_strings":["Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033074082","display_name":"Shao\u2010Cong Sun","orcid":"https://orcid.org/0000-0001-7353-9400","observed_orcids":["https://orcid.org/0000-0001-7353-9400"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Sun","raw_affiliation_strings":["Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111701788","display_name":"Douglas C. Kuhn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. C. Kuhn","raw_affiliation_strings":["Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017785941","display_name":"Lesley J. Gaydos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. J. Gaydos","raw_affiliation_strings":["Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088517899","display_name":"Xianglin Shi","orcid":"https://orcid.org/0000-0001-9512-7570","observed_orcids":["https://orcid.org/0000-0001-9512-7570"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Shi","raw_affiliation_strings":["Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Lu","raw_affiliation_strings":["Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108446582","display_name":"Laurence M. Demers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. M. Demers","raw_affiliation_strings":["Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Pennsylvania State University College ofMedicine, The Milton S. Hershey Medical Center, 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9898,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.73955743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"272","issue":"4","first_page":"L779","last_page":"L786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/silica","display_name":"silica","score":0.7620000243186951},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nr8383-cells","display_name":"NR8383 cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/kappab-site","display_name":"kappaB site","score":0.7580000162124634},{"id":"https://openalex.org/keywords/5-flanking-region","display_name":"5'-flanking region","score":0.8029999732971191},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0}],"concepts":[{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.6974080801010132},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6025490760803223},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5803244113922119},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4914511442184448},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4768589437007904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4755277931690216},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47023671865463257},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.45436790585517883},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.448282390832901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44677990674972534},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43796318769454956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3888392150402069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37400487065315247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2669553756713867},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20326682925224304},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07345464825630188}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.1997.272.4.l779","doi":"https://doi.org/10.1152/ajplung.1997.272.4.l779","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1997.272.4.l779","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:9142954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9142954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065856553","https://openalex.org/W2002145523","https://openalex.org/W2151114770","https://openalex.org/W110280024","https://openalex.org/W1481758121","https://openalex.org/W2054106494","https://openalex.org/W3214869368","https://openalex.org/W4211120477","https://openalex.org/W2377506632","https://openalex.org/W2141422576"],"abstract_inverted_index":{"The":[0,100,129],"role":[1],"of":[2,41,51,83,95,166,189],"nuclear":[3],"factor":[4,7],"(NF)-kappaB":[5],"transcription":[6],"in":[8,17,33,44,79,109,114,124,138,146,149],"silica-induced":[9,92,159,182,190],"cyclooxygenase":[10],"(COX)":[11],"II":[12,53,87,98,121,144],"gene":[13,68,88],"expression":[14],"was":[15,135,155,177],"examined":[16],"the":[18,80,84,96,119,139,167,174,187],"rat":[19,85,142],"alveolar":[20],"macrophage":[21],"cell":[22,35],"line":[23,36],"NR8383.":[24],"Our":[25],"results":[26,194],"indicate":[27],"that":[28,73,196],"NF-kappaB":[29,42,160,183,203],"can":[30],"be":[31],"activated":[32],"this":[34],"by":[37,57,173,185],"silica":[38],"exposure.":[39],"Suppression":[40],"activation":[43,184,204],"these":[45],"cells":[46],"leads":[47],"to":[48,157,180],"an":[49,60,197],"attenuation":[50],"COX":[52,86,97,120,143,153,175,206],"mRNA":[54],"accumulation":[55],"induced":[56],"silica.":[58],"Using":[59],"electrophoretic":[61],"mobility":[62],"shift":[63],"assay":[64],"and":[65,111,127,141,148,205],"a":[66,115,152],"reporter":[67],"assay,":[69],"we":[70],"provide":[71],"evidence":[72],"at":[74],"least":[75],"two":[76],"kappaB":[77],"sites":[78],"5'-flanking":[81],"region":[82],"are":[89],"involved":[90],"for":[91],"transcriptional":[93],"control":[94],"gene.":[99],"first":[101],"motif,":[102,131],"-404":[103],"GGGGATTCCC":[104],"-395,":[105],"is":[106,112],"absolutely":[107],"conserved":[108,136],"sequence":[110,147],"localized":[113],"similar":[116],"position":[117],"among":[118],"genes":[122,145],"found":[123],"humans,":[125],"rats,":[126],"mice.":[128],"second":[130],"-91":[132],"GGGGAAAGCC":[133],"-82,":[134],"only":[137],"mouse":[140],"location.":[150],"Aspirin,":[151],"inhibitor,":[154],"shown":[156,179],"suppress":[158],"activation.":[161],"However,":[162],"prostaglandin":[163],"E2,":[164],"one":[165],"important":[168],"downstream":[169],"reaction":[170],"products":[171],"catalyzed":[172],"enzyme,":[176],"also":[178],"attenuate":[181],"retarding":[186],"degradation":[188],"inhibitor":[191],"NF-kappaB.":[192],"These":[193],"suggest":[195],"interdependent":[198],"regulation":[199],"may":[200],"exist":[201],"between":[202],"or":[207],"its":[208],"products.":[209]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
