{"id":"https://openalex.org/W2408598201","doi":"https://doi.org/10.1182/blood.v77.8.1754.1754","title":"In vivo and in vitro complexes of activated protein C with two inhibitors in baboons","display_name":"In vivo and in vitro complexes of activated protein C with two inhibitors in baboons","publication_year":1991,"publication_date":"1991-04-15","ids":{"openalex":"https://openalex.org/W2408598201","doi":"https://doi.org/10.1182/blood.v77.8.1754.1754","mag":"2408598201","pmid":"https://pubmed.ncbi.nlm.nih.gov/1849759"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v77.8.1754.1754","doi":"https://doi.org/10.1182/blood.v77.8.1754.1754","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v77.8.1754.1754","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079018683","display_name":"Francisco Espa\u00f1a","orcid":"https://orcid.org/0000-0001-7829-2021","observed_orcids":["https://orcid.org/0000-0001-7829-2021"]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Espana","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036237322","display_name":"Andr\u00e1s Gruber","orcid":"https://orcid.org/0000-0001-6212-2247","observed_orcids":["https://orcid.org/0000-0001-6212-2247"]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Gruber","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109189203","display_name":"MJ Heeb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MJ Heeb","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023084493","display_name":"SR Hanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SR Hanson","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020795365","display_name":"LA Harker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LA Harker","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102759807","display_name":"John H. Griffin","orcid":"https://orcid.org/0000-0002-4302-2547","observed_orcids":["https://orcid.org/0000-0002-4302-2547"]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JH Griffin","raw_affiliation_strings":["Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Committee on Vascular Biology, Scripps Clinic and Research Foundation, La Jolla, CA","institution_ids":["https://openalex.org/I4210146328"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210146328"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":4.3148,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.94723183,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"77","issue":"8","first_page":"1754","last_page":"1760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activated-protein-c","display_name":"activated protein C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-c-inhibitor","display_name":"protein C inhibitor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.5},{"id":"https://openalex.org/keywords/complex-formation","display_name":"complex formation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.7458831071853638},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.6909787058830261},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.602977454662323},{"id":"https://openalex.org/C51296783","wikidata":"https://www.wikidata.org/wiki/Q1645498","display_name":"Microgram","level":3,"score":0.581979513168335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4609421491622925},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45141837000846863},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.4282490611076355},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3754430115222931},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36484652757644653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35032543540000916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24407607316970825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17914459109306335},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018046","descriptor_name":"Protein C Inhibitor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v77.8.1754.1754","doi":"https://doi.org/10.1182/blood.v77.8.1754.1754","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v77.8.1754.1754","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v77.8.1754.bloodjournal7781754","doi":"https://doi.org/10.1182/blood.v77.8.1754.bloodjournal7781754","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v77.8.1754.bloodjournal7781754","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:1849759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1849759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1598059594","display_name":null,"funder_award_id":"HL 31950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G882865996","display_name":"Thrombus Formation and Antithrombotic Intervention","funder_award_id":"P01HL031950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W63702810","https://openalex.org/W90676001","https://openalex.org/W184609806","https://openalex.org/W1512865667","https://openalex.org/W1517450192","https://openalex.org/W1562054825","https://openalex.org/W1568212318","https://openalex.org/W1569894631","https://openalex.org/W1696947947","https://openalex.org/W1827982969","https://openalex.org/W1967496809","https://openalex.org/W1991766612","https://openalex.org/W1999591312","https://openalex.org/W2006122994","https://openalex.org/W2030037447","https://openalex.org/W2032711004","https://openalex.org/W2038058775","https://openalex.org/W2038681046","https://openalex.org/W2072829381","https://openalex.org/W2074044112","https://openalex.org/W2085445739","https://openalex.org/W2112348962","https://openalex.org/W2150615418","https://openalex.org/W2236732062","https://openalex.org/W2413507176","https://openalex.org/W2414396290","https://openalex.org/W2414783014","https://openalex.org/W2468412663","https://openalex.org/W4298033051"],"related_works":["https://openalex.org/W2414396290","https://openalex.org/W2412666823","https://openalex.org/W2413507176","https://openalex.org/W2072829381","https://openalex.org/W2431263889","https://openalex.org/W1479798081","https://openalex.org/W2030037447","https://openalex.org/W1825221379","https://openalex.org/W341188615","https://openalex.org/W2026024760"],"abstract_inverted_index":{"In":[0],"vivo":[1,236],"complex":[2,54,70,138],"formation":[3,237],"of":[4,21,51,87,113,147,165,177,204,211,238,240,265,278,286],"activated":[5],"protein":[6,9,148],"C":[7,10,149],"with":[8,14,189,242],"inhibitor":[11,245,285],"(APC-PCI)":[12],"and":[13,36,67,79,129,171,173,180,199,206,220,224,259,267],"alpha":[15,260,280],"1-antitrypsin":[16],"(APC-alpha":[17],"1AT)":[18],"following":[19],"infusion":[20,114,146],"0.25":[22],"or":[23],"1.0":[24,196],"mg":[25],"APC/kg":[26],"in":[27,57,152,159,235,248,250],"1":[28,85,111,153,228],"hour":[29,86,112],"into":[30],"baboons":[31],"was":[32,97,119],"studied":[33],"using":[34],"immunoblotting":[35],"sandwich":[37],"enzyme-linked":[38],"immunosorbent":[39],"assay":[40],"(ELISA)s.":[41],"Before":[42],"APC":[43,64,92,170,214,241,266],"infusion,":[44],"detectable":[45],"plasma":[46,194,217],"levels":[47,71,139],"(about":[48],"30":[49,107],"ng/mL)":[50],"APC-alpha":[52,68,101,116,174,207,225],"1AT":[53,69,102,117,175,226,261,281],"were":[55,72,157,184],"found":[56],"the":[58,62,90,94,100,105,115,122,283],"baboon":[59,193,216],"plasma.":[60,252],"At":[61,89],"lower":[63],"dose,":[65,93],"APC-PCI":[66,95,123,172,205,223],"1.4":[73],"+/-":[74,77,81,127,131,197,201],"0.3":[75],"(mean":[76],"SD)":[78],"0.8":[80,200],"0.1":[82,202],"microgram/mL":[83,203],"after":[84,110,227],"infusion.":[88],"higher":[91,120],"level":[96,103,118],"similar":[98],"to":[99,142,215],"during":[104],"first":[106],"minutes,":[108,182],"but":[109,246],"than":[121],"level,":[124],"reaching":[125],"4.1":[126],"1.2":[128,132],"2.9":[130],"microgram/mL,":[133],"respectively.":[134,209,230],"After":[135,186],"24":[136],"hours,":[137],"had":[140],"returned":[141],"basal":[143],"conditions.":[144],"During":[145],"(1.0":[150],"mg/kg":[151],"hour),":[154],"both":[155,257],"complexes":[156,176,239],"detected":[158],"low":[160],"concentrations.":[161],"Following":[162],"bolus":[163],"injection":[164],"APC,":[166,192,279],"half-lives":[167],"(t1/2)":[168],"for":[169],"10,":[178],"40,":[179],"140":[181],"respectively,":[183],"observed.":[185],"1-hour":[187],"incubation":[188],"2.5":[190,219],"micrograms/mL":[191,213,222],"contained":[195],"0.2":[198],"1AT,":[208],"Addition":[210],"10":[212],"yielded":[218],"2.4":[221],"hour,":[229],"Immunoblotting":[231],"analysis":[232],"also":[233],"showed":[234],"an":[243],"auxilliary":[244],"not":[247],"vitro":[249],"citrated":[251],"These":[253],"data":[254],"show":[255],"that":[256,269],"PCI":[258,271],"are":[262],"physiologic":[263],"inhibitors":[264],"suggest":[268],"when":[270],"is":[272],"depleted":[273],"by":[274],"a":[275],"high":[276],"dose":[277],"becomes":[282],"major":[284],"APC.":[287]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}