{"id":"https://openalex.org/W2408355348","doi":null,"title":"Status of oxidant, antioxidantand serum enzymes in thalassaemic children receiving multiple blood transfusions.","display_name":"Status of oxidant, antioxidantand serum enzymes in thalassaemic children receiving multiple blood transfusions.","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2408355348","mag":"2408355348","pmid":"https://pubmed.ncbi.nlm.nih.gov/26228327"},"language":"en","primary_location":{"id":"pmid:26228327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26228327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JPMA. The Journal of the Pakistan Medical Association","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048117520","display_name":"Mahmood Asif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I224549313","display_name":"Punjab Medical College","ror":"https://ror.org/04hbpw172","country_code":"PK","type":"education","lineage":["https://openalex.org/I224549313"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mahmood Asif","raw_affiliation_strings":["Department of Physiology, Punjab Medical College, Faisalabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Punjab Medical College, Faisalabad, Pakistan","institution_ids":["https://openalex.org/I224549313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043049404","display_name":"Zahid Manzoor","orcid":"https://orcid.org/0009-0003-2632-9939","observed_orcids":["https://orcid.org/0009-0003-2632-9939","https://orcid.org/0000-0002-2840-6788"]},"institutions":[{"id":"https://openalex.org/I196431481","display_name":"Isra University","ror":"https://ror.org/04rmz8121","country_code":"PK","type":"education","lineage":["https://openalex.org/I196431481"]},{"id":"https://openalex.org/I92449659","display_name":"Isra University","ror":"https://ror.org/04d4bt482","country_code":"JO","type":"education","lineage":["https://openalex.org/I92449659"]}],"countries":["JO","PK"],"is_corresponding":false,"raw_author_name":"Zahid Manzoor","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine & Allied Medical Sciences, Al-Nafees Medical College, Isra University, Islamabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine & Allied Medical Sciences, Al-Nafees Medical College, Isra University, Islamabad","institution_ids":["https://openalex.org/I196431481","https://openalex.org/I92449659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110392686","display_name":"Muhammad Shehzad Farooq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I224549313","display_name":"Punjab Medical College","ror":"https://ror.org/04hbpw172","country_code":"PK","type":"education","lineage":["https://openalex.org/I224549313"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Shehzad Farooq","raw_affiliation_strings":["Department of Biochemistry, Punjab Medical College, Faisalabad, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Punjab Medical College, Faisalabad, Pakistan","institution_ids":["https://openalex.org/I224549313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112602940","display_name":"Shaukat Hussain Munawar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196431481","display_name":"Isra University","ror":"https://ror.org/04rmz8121","country_code":"PK","type":"education","lineage":["https://openalex.org/I196431481"]},{"id":"https://openalex.org/I92449659","display_name":"Isra University","ror":"https://ror.org/04d4bt482","country_code":"JO","type":"education","lineage":["https://openalex.org/I92449659"]}],"countries":["JO","PK"],"is_corresponding":false,"raw_author_name":"Shaukat Hussain Munawar","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine & Allied Medical Sciences, Al-Nafees Medical College, Isra University, Islamabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine & Allied Medical Sciences, Al-Nafees Medical College, Isra University, Islamabad","institution_ids":["https://openalex.org/I196431481","https://openalex.org/I92449659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065243899","display_name":"Abdul Aziz","orcid":"https://orcid.org/0000-0001-5393-3806","observed_orcids":["https://orcid.org/0000-0001-5393-3806"]},"institutions":[{"id":"https://openalex.org/I127670440","display_name":"Bahauddin Zakariya University","ror":"https://ror.org/05x817c41","country_code":"PK","type":"education","lineage":["https://openalex.org/I127670440"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abdul Aziz","raw_affiliation_strings":["Faculty of Pharmacy, BahauddinZakariya University, Multan, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, BahauddinZakariya University, Multan, Pakistan","institution_ids":["https://openalex.org/I127670440"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101830101","display_name":"Imran Ahmad Khan","orcid":"https://orcid.org/0000-0002-8761-8879","observed_orcids":["https://orcid.org/0000-0002-8761-8879"]},"institutions":[{"id":"https://openalex.org/I127670440","display_name":"Bahauddin Zakariya University","ror":"https://ror.org/05x817c41","country_code":"PK","type":"education","lineage":["https://openalex.org/I127670440"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Imran Ahmad Khan","raw_affiliation_strings":["Faculty of Pharmacy, BahauddinZakariya University, Multan, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, BahauddinZakariya University, Multan, Pakistan","institution_ids":["https://openalex.org/I127670440"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4117,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79918242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"65","issue":"8","first_page":"838","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalassemia","display_name":"thalassemia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6549999713897705},{"id":"https://openalex.org/keywords/multiple-transfusion","display_name":"multiple blood transfusion","score":0.9129999876022339},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.6650000214576721},{"id":"https://openalex.org/keywords/oxidant-status","display_name":"oxidant status","score":0.9049999713897705},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9190000295639038},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.996999979019165},{"id":"https://openalex.org/keywords/paraoxonase","display_name":"paraoxonase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/arylesterase","display_name":"arylesterase","score":0.984000027179718},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":1.0},{"id":"https://openalex.org/keywords/ceruloplasmin","display_name":"ceruloplasmin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.8190000057220459},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8721600770950317},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.7474125623703003},{"id":"https://openalex.org/C2781389560","wikidata":"https://www.wikidata.org/wiki/Q4802704","display_name":"Arylesterase","level":5,"score":0.5127543210983276},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.5026414394378662},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4733296036720276},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.4701804220676422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4636342227458954},{"id":"https://openalex.org/C2776509667","wikidata":"https://www.wikidata.org/wiki/Q7135605","display_name":"Paraoxonase","level":3,"score":0.45182982087135315},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35441410541534424},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34352755546569824},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.24288088083267212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2313714623451233},{"id":"https://openalex.org/C37501387","wikidata":"https://www.wikidata.org/wiki/Q18030661","display_name":"PON1","level":4,"score":0.12583616375923157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06633460521697998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002570","descriptor_name":"Ceruloplasmin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26228327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26228327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JPMA. The Journal of the Pakistan Medical Association","raw_type":"Journal Article"},{"id":"mag:2408355348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26228327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W66608086","https://openalex.org/W1976464405","https://openalex.org/W1983310681","https://openalex.org/W1989100625","https://openalex.org/W1992515297","https://openalex.org/W2004274286","https://openalex.org/W2007619249","https://openalex.org/W2035301690","https://openalex.org/W2038287973","https://openalex.org/W2042203706","https://openalex.org/W2091347655","https://openalex.org/W2123152382","https://openalex.org/W2123764858","https://openalex.org/W2142473051","https://openalex.org/W2168313839","https://openalex.org/W2187345901","https://openalex.org/W2328142025"],"related_works":["https://openalex.org/W6893571021","https://openalex.org/W2497300277","https://openalex.org/W2942576676","https://openalex.org/W2792975918","https://openalex.org/W2113804586","https://openalex.org/W2103655963","https://openalex.org/W2808701174","https://openalex.org/W3110998861","https://openalex.org/W1568104861","https://openalex.org/W2770521606"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3,44,65,72,96,104,110,116,151,158,173,190,207],"levels":[4,144,191],"of":[5,74,112,121,154,160,192,198,206,217,232],"oxidant,":[6],"antioxidant":[7,79,127,220],"and":[8,29,43,88,100,125,142,195,219],"serum":[9,81,161,196],"enzymes":[10,197],"in":[11,47,95,115,133,170,182,211,225],"thalassaemic":[12,31,134,199,226],"children":[13,32,94,135],"receiving":[14,33],"multiple":[15,34,179],"blood":[16,35,180,187],"transfusions.":[17],"METHODS:":[18],"The":[19,119],"case-control":[20],"study":[21],"was":[22,114],"done":[23],"from":[24],"February":[25],"to":[26,137],"August":[27],"2012,":[28],"comprised":[30],"transfusions":[36,181,188],"at":[37],"Allied":[38],"Hospital,":[39,49],"Ali":[40],"Zeb":[41],"Foundation,":[42],"Thalassaemia":[45],"Centre":[46],"Hilal-e-Ahmar":[48],"Faisalabad,":[50],"Pakistan.":[51],"Healthy":[52],"subjects":[53],"were":[54,69,92,107,129,145,166],"also":[55,146],"screened":[56],"for":[57,71],"any":[58],"related":[59],"disease":[60],"condition":[61],"that":[62],"could":[63],"prejudice":[64],"results.":[66],"Blood":[67],"samples":[68],"analysed":[70],"values":[73,120],"total":[75,78,122,126],"oxidant":[76,123,218],"status,":[77],"capacity,":[80],"malondialdehyde,":[82],"catalase,":[83],"paraoxonase,":[84,162],"arylesterase,":[85,163],"glutathione":[86,164],"peroxidase":[87,165],"ceruloplasmin.":[89],"RESULTS:":[90],"There":[91],"180":[93],"study;":[97],"90(50%)":[98,101],"cases":[99,171],"controls.":[102],"Of":[103],"cases,":[105],"48(53.3%)":[106],"under-weight":[108],"while":[109],"weight":[111],"42(46.7%)":[113],"normal":[117,138],"range.":[118],"status":[124,221],"capacity":[128],"significantly":[130,167],"(p<0.01)":[131,168],"higher":[132],"compared":[136],"values.":[139],"Serum":[140],"malondialdehyde":[141],"catalase":[143],"considerably":[147],"elevated":[148],"(p<0.05),":[149],"suggesting":[150],"increased":[152,208],"activity":[153],"these":[155,183,212],"enzymes.":[156],"However,":[157],"concentrations":[159],"lower":[169],"than":[172],"controls,":[174],"displaying":[175],"diminished":[176],"activities":[177],"during":[178,228],"patients.":[184,213],"CONCLUSIONS:":[185],"Multiple":[186],"disconcert":[189],"oxidants,":[193],"antioxidants":[194],"children.":[200],"Oxidative":[201],"damage":[202],"is":[203],"seen":[204],"because":[205],"iron":[209],"overload":[210],"Hence,":[214],"regular":[215],"evaluation":[216],"should":[222],"be":[223],"monitored":[224],"patients":[227],"initial":[229],"few":[230],"years":[231],"life.":[233]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}