{"id":"https://openalex.org/W2408354580","doi":null,"title":"Effect of hyperbarism on collagenous protein metabolism in granulation tissue.","display_name":"Effect of hyperbarism on collagenous protein metabolism in granulation tissue.","publication_year":1975,"publication_date":"1975-01-01","ids":{"openalex":"https://openalex.org/W2408354580","mag":"2408354580","pmid":"https://pubmed.ncbi.nlm.nih.gov/125887"},"language":"en","primary_location":{"id":"pmid:125887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/125887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiologia Bohemoslovaca","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057182681","display_name":"E Mirejovsk\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Mirejovsk\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059836345","display_name":"P Mirejovsk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Mirejovsk\u00fd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025288435","display_name":"JOSEF HURYCH","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Hurych","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34209858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"4","first_page":"345","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-atmospheric-pressure","display_name":"high atmospheric pressure","score":0.6370000243186951},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.8669999837875366},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/collagen-maturation","display_name":"collagen maturation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/collagen-degradation","display_name":"collagen degradation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hydroxyproline","display_name":"hydroxyproline","score":0.9440000057220459},{"id":"https://openalex.org/keywords/non-collagenous-proteins","display_name":"non-collagenous proteins","score":0.7860000133514404},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7900000214576721},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.6790000200271606},{"id":"https://openalex.org/keywords/lysosomal-activation","display_name":"lysosomal activation","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.9526023864746094},{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.9187654256820679},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6634758710861206},{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.6353530287742615},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6049533486366272},{"id":"https://openalex.org/C2780140890","wikidata":"https://www.wikidata.org/wiki/Q1129338","display_name":"Granuloma","level":2,"score":0.5476348996162415},{"id":"https://openalex.org/C88463166","wikidata":"https://www.wikidata.org/wiki/Q1543243","display_name":"Granulation","level":2,"score":0.5289304852485657},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.4629875421524048},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4458167552947998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40529128909111023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.277142733335495},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.2549005448818207},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21944940090179443},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.20561927556991577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16928258538246155},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14080917835235596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1321830153465271},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10009288787841797},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08641490340232849},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001274","descriptor_name":"Atmospheric Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006909","descriptor_name":"Hydroxyproline","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006931","descriptor_name":"Hyperbaric Oxygenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:125887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/125887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiologia Bohemoslovaca","raw_type":"Journal Article"},{"id":"mag:2408354580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/125887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2271900527","https://openalex.org/W2400432905","https://openalex.org/W1692992725","https://openalex.org/W2330721714","https://openalex.org/W2404692673","https://openalex.org/W366121018","https://openalex.org/W1991133334","https://openalex.org/W2125821864","https://openalex.org/W985931079","https://openalex.org/W2029909609"],"abstract_inverted_index":{"Rats":[0],"with":[1,146],"subcutaneously":[2],"implanted":[3],"polyurethane":[4],"sponges":[5],"were":[6,62,77,144],"exposed":[7,28],"6":[8],"hours":[9,30,47],"daily":[10,31],"for":[11,32,213],"7":[12],"days":[13],"to":[14,35,92,124,137,200],"high":[15],"ambient":[16],"atmospheric":[17],"pressures":[18],"(1.5,":[19],"2,":[20,116,183],"2.5":[21,100,117,184],"and":[22,55,58,68,71,75,99,118,174,185,195],"3":[23,36,105,119,128,186,204],"ATA).":[24],"Another":[25],"group":[26],"was":[27,44,95,113,163],"4":[29,33],"weeks":[34],"ATA":[37,129],"before":[38,48],"inducing":[39],"granulation":[40,154,214],"tissue":[41],"formation.":[42],"14C-proline":[43,76],"administered":[45],"16":[46],"terminating":[49],"the":[50,65,69,88,131,134,149,153,159,178,191,201],"experiment.":[51],"Free":[52],"hydroxyproline,":[53],"soluble":[54],"insoluble":[56,93,138],"collagen":[57,86,91,110,132],"total":[59],"noncollagenous":[60],"protein":[61],"isolated":[63],"from":[64],"7-day":[66],"granuloma":[67,135],"amount":[70],"radioactivity":[72],"of":[73,90,109,152,158,172,193],"14C-hydroxyproline":[74],"determined.":[78],"Seven":[79],"days'":[80],"graduated":[81],"hyperbarism":[82],"did":[83],"not":[84,103,164],"affect":[85],"synthesis;":[87],"maturation":[89],"forms":[94,139],"inhibited":[96],"at":[97,104,115,127,182,203],"2":[98],"ATA,":[101,205],"but":[102],"ATA.":[106,120,187],"Stimulated":[107],"degradation":[108],"(free":[111],"hydroxyproline)":[112],"observed":[114],"In":[121,188],"animals":[122],"subjected":[123],"long-term":[125],"exposure":[126],"pressure,":[130],"in":[133,148,177],"matured":[136],"more":[140],"quickly.":[141],"Biochemical":[142],"changes":[143,147],"correlated":[145],"fine":[150],"structure":[151],"tissue.":[155,215],"The":[156],"appearance":[157],"fibroblast":[160],"proteosynthetic":[161],"apparatus":[162],"influenced":[165],"by":[166],"hyperbarism.":[167],"Progressive":[168],"spherical":[169],"transformation,":[170],"fusion":[171],"mitochondria":[173],"lysosomal":[175],"activation":[176],"pericapillary":[179],"fibroblasts":[180],"occurred":[181],"short-term":[189],"experiment,":[190],"formation":[192],"cytosegresomes":[194],"cellular":[196],"necrosis":[197],"also":[198],"contributed":[199],"effect":[202],"which":[206],"is":[207],"thus":[208],"already":[209],"a":[210],"toxic":[211],"pressure":[212]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}