{"id":"https://openalex.org/W2408352480","doi":"https://doi.org/10.1152/ajpheart.1997.273.3.h1324","title":"Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits","display_name":"Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2408352480","doi":"https://doi.org/10.1152/ajpheart.1997.273.3.h1324","mag":"2408352480","pmid":"https://pubmed.ncbi.nlm.nih.gov/9321822"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1997.273.3.h1324","doi":"https://doi.org/10.1152/ajpheart.1997.273.3.h1324","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1997.273.3.h1324","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072860296","display_name":"Claudio J. Maldonado","orcid":"https://orcid.org/0000-0002-2034-2273","observed_orcids":["https://orcid.org/0000-0002-2034-2273"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Maldonado","raw_affiliation_strings":["Experimental Research Laboratory, University of Louisville, Kentucky40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Research Laboratory, University of Louisville, Kentucky40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029768980","display_name":"Yumin Qiu","orcid":"https://orcid.org/0000-0002-5609-0784","observed_orcids":["https://orcid.org/0000-0002-5609-0784"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Qiu","raw_affiliation_strings":["Experimental Research Laboratory, University of Louisville, Kentucky40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Research Laboratory, University of Louisville, Kentucky40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000397083","display_name":"Xian\u2010Liang Tang","orcid":"https://orcid.org/0000-0002-5987-340X","observed_orcids":["https://orcid.org/0000-0002-5987-340X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. L. Tang","raw_affiliation_strings":["Experimental Research Laboratory, University of Louisville, Kentucky40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Research Laboratory, University of Louisville, Kentucky40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022509151","display_name":"M. V. Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. V. Cohen","raw_affiliation_strings":["Experimental Research Laboratory, University of Louisville, Kentucky40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Research Laboratory, University of Louisville, Kentucky40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060190034","display_name":"John A. Auchampach","orcid":"https://orcid.org/0000-0002-8005-4599","observed_orcids":["https://orcid.org/0000-0002-8005-4599"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Auchampach","raw_affiliation_strings":["Experimental Research Laboratory, University of Louisville, Kentucky40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Research Laboratory, University of Louisville, Kentucky40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008671980","display_name":"Roberto Bolli","orcid":"https://orcid.org/0000-0002-9160-8614","observed_orcids":["https://orcid.org/0000-0002-9160-8614"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Bolli","raw_affiliation_strings":["Experimental Research Laboratory, University of Louisville, Kentucky40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Research Laboratory, University of Louisville, Kentucky40292, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":6.1257,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.96937192,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"273","issue":"3","first_page":"H1324","last_page":"H1332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.8960000276565552},{"id":"https://openalex.org/keywords/late-preconditioning","display_name":"late preconditioning","score":0.9789999723434448},{"id":"https://openalex.org/keywords/adenosine-receptors","display_name":"adenosine receptors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.800000011920929},{"id":"https://openalex.org/keywords/8-p-sulfophenyl-theophylline","display_name":"8-(p-sulfophenyl)theophylline","score":0.9259999990463257},{"id":"https://openalex.org/keywords/2-chloro-n6-cyclopentyladenosine","display_name":"2-chloro-N6-cyclopentyladenosine","score":0.9359999895095825},{"id":"https://openalex.org/keywords/coronary-artery-occlusion","display_name":"coronary artery occlusion","score":0.7379999756813049},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.8169999718666077},{"id":"https://openalex.org/keywords/systolic-wall-thickening","display_name":"systolic wall thickening","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2778492669","wikidata":"https://www.wikidata.org/wiki/Q7628762","display_name":"Stunning","level":3,"score":0.8947737812995911},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.7749682664871216},{"id":"https://openalex.org/C2775992611","wikidata":"https://www.wikidata.org/wiki/Q2075261","display_name":"Myocardial stunning","level":3,"score":0.680026113986969},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.49148309230804443},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4882562458515167},{"id":"https://openalex.org/C2779311647","wikidata":"https://www.wikidata.org/wiki/Q17148404","display_name":"Ischemic preconditioning","level":3,"score":0.4475133419036865},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4351941645145416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43162068724632263},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42775827646255493},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3905888795852661},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.1324729025363922},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.0999724268913269}],"mesh":[{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013599","descriptor_name":"Systole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015425","descriptor_name":"Myocardial Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018047","descriptor_name":"Receptors, Purinergic P1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019157","descriptor_name":"Ischemic Preconditioning, Myocardial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058915","descriptor_name":"Purinergic P1 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1997.273.3.h1324","doi":"https://doi.org/10.1152/ajpheart.1997.273.3.h1324","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1997.273.3.h1324","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:9321822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9321822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2528103329","display_name":"OXYGEN RADICALS AND POSTISCHEMIC DYSFUNCTION","funder_award_id":"R01HL043151","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G424334138","display_name":"CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING","funder_award_id":"R01HL050688","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G482390063","display_name":null,"funder_award_id":"HL 55757","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985080442","https://openalex.org/W2316951438","https://openalex.org/W2048782803","https://openalex.org/W6886238924","https://openalex.org/W2161074774","https://openalex.org/W2416074078","https://openalex.org/W2127186576","https://openalex.org/W3151727041","https://openalex.org/W2160260475","https://openalex.org/W2007330950"],"abstract_inverted_index":{"Conscious":[0],"rabbits":[1,157],"underwent":[2,28],"six":[3],"4-min":[4,9],"coronary":[5],"occlusions":[6],"interspersed":[7],"with":[8,159,168,227,242],"periods":[10],"of":[11,21,36,77,100,116,125,132,178,212,224,238,254],"reperfusion":[12],"for":[13,87,191],"2":[14,20,24,35,142],"consecutive":[15],"days":[16],"(days":[17,32],"1":[18,33,48,62,76,109,146],"and":[19,34,72,199],"stage":[22,37,78,135,171],"I);":[23],"wk":[25],"later,":[26],"they":[27,41],"the":[29,58,97,114,130,176,210,252],"same":[30],"protocol":[31],"II)":[38],"except":[39],"that":[40,195,245],"received":[42],"either":[43,228],"8-(p-sulfophenyl)theophylline":[44],"(SPT)":[45],"on":[46,57,74,93,107,140,144,161,180],"day":[47,59,61,75,94,108,141,145,162,181],"(group":[49,63],"I,":[50,79],"n":[51,65],"=":[52,66],"5)":[53],"or":[54,230],"2-chloro-N6-cyclopentyl-adenosine":[55],"(CCPA)":[56],"before":[60],"II,":[64,73,166],"6).":[67],"In":[68,164,207],"both":[69],"groups":[70],"I":[71,129],"systolic":[80],"wall":[81],"thickening":[82],"(WTh)":[83],"remained":[84],"significantly":[85],"depressed":[86],"several":[88],"hours,":[89],"indicating":[90,113,244],"myocardial":[91,121,193,216],"stunning;":[92],"2,":[95],"however,":[96],"total":[98],"deficit":[99,131,177],"WTh":[101,133,179],"was":[102,137],"approximately":[103],"50%":[104],"less":[105,139,201],"than":[106,143,203],"(P":[110,147],"<":[111,148],"0.01),":[112],"development":[115,211],"late":[117,213],"preconditioning":[118],"(PC)":[119],"against":[120,215],"stunning.":[122],"Despite":[123],"administration":[124],"SPT,":[126],"in":[127,154,251],"group":[128,165],"during":[134,170],"II":[136,172],"55%":[138],"0.05).":[149],"Similar":[150],"results":[151],"were":[152],"obtained":[153],"three":[155],"other":[156],"treated":[158],"PD-115199":[160],"1.":[163,182],"pretreatment":[167],"CCPA":[169],"failed":[173],"to":[174],"decrease":[175],"This":[183],"study":[184],"presents":[185],"a":[186],"new":[187],"conscious":[188],"rabbit":[189],"model":[190],"studying":[192],"stunning":[194,217],"is":[196,218,233],"relatively":[197],"inexpensive":[198],"technically":[200],"demanding":[202],"larger":[204],"animal":[205],"models.":[206],"this":[208,255],"model,":[209],"PC":[214],"not":[219,249],"blocked":[220],"by":[221,236],"nonselective":[222],"blockade":[223],"adenosine":[225,239,246],"receptors":[226,241,247],"SPT":[229],"PD-115199,":[231],"nor":[232],"it":[234],"induced":[235],"activation":[237],"A1":[240],"CCPA,":[243],"are":[248],"involved":[250],"pathogenesis":[253],"phenomenon.":[256]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}