{"id":"https://openalex.org/W2408265232","doi":null,"title":"Activated protein C resistance and pregnancy - Department's of Haematology, Coltea Clinical Hospital experience","display_name":"Activated protein C resistance and pregnancy - Department's of Haematology, Coltea Clinical Hospital experience","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2408265232","mag":"2408265232"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.507.7058","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.507.7058","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.maedica.org/articole/nr2_2009/Art_02.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Simona Elena Avram","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Elena Avram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031715758","display_name":"Anca Roxana Lupu","orcid":"https://orcid.org/0000-0002-3353-6683","observed_orcids":["https://orcid.org/0000-0002-3353-6683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anca Roxana Lupu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3353-6683","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087543915","display_name":"Oana Stanca Ciocan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oana Stanca Ciocan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077941571","display_name":"Nicoleta Mariana BERBEC","orcid":"https://orcid.org/0000-0002-4638-3479","observed_orcids":["https://orcid.org/0000-0002-4638-3479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicoleta Berbec","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4638-3479","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012748602","display_name":"Andrei Coli\u0163\u0103","orcid":"https://orcid.org/0000-0002-6531-7717","observed_orcids":["https://orcid.org/0000-0002-6531-7717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrei Coli\u0163\u0103","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6531-7717","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109306933","display_name":"Silvana Angelescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvana Angelescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044880651","display_name":"Carmen \u0218aguna","orcid":"https://orcid.org/0009-0003-6213-0142","observed_orcids":["https://orcid.org/0009-0003-6213-0142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen \u0218aguna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004668565","display_name":"Ileana Delia Mut","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ileana Delia Mut","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activated-protein-c-resistance","display_name":"activated protein C resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.8410000205039978},{"id":"https://openalex.org/keywords/thrombophilia","display_name":"thrombophilia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.8500000238418579},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.656000018119812},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8980000019073486},{"id":"https://openalex.org/keywords/placental-vasculature","display_name":"placental vasculature","score":0.8050000071525574},{"id":"https://openalex.org/keywords/thrombosis-screening","display_name":"thrombosis screening","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2779956388","wikidata":"https://www.wikidata.org/wiki/Q296104","display_name":"Activated protein C resistance","level":5,"score":0.8725423812866211},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.8135179281234741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.799367368221283},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.606974720954895},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.5794922113418579},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5580115914344788},{"id":"https://openalex.org/C2780842393","wikidata":"https://www.wikidata.org/wiki/Q1570013","display_name":"Thrombophilia","level":3,"score":0.5181342363357544},{"id":"https://openalex.org/C2776135265","wikidata":"https://www.wikidata.org/wiki/Q419774","display_name":"Protein S","level":3,"score":0.5035068392753601},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.49747541546821594},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.49677640199661255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4412786662578583},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.4229884743690491},{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.3666905164718628},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.14415904879570007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08118632435798645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06022182106971741}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.507.7058","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.507.7058","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.maedica.org/articole/nr2_2009/Art_02.pdf","raw_type":"text"},{"id":"mag:2408265232","doi":null,"is_oa":false,"landing_page_url":"http://www.maedica.org/articles/2009/2009_Vol4(7)_No2/2009_Vol4(7)_No2_pg100-105.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W87579421","https://openalex.org/W1510008853","https://openalex.org/W1596313173","https://openalex.org/W1966708143","https://openalex.org/W1968930113","https://openalex.org/W1970442833","https://openalex.org/W1987737906","https://openalex.org/W1995474189","https://openalex.org/W2000296190","https://openalex.org/W2011784685","https://openalex.org/W2064175400","https://openalex.org/W2064806361","https://openalex.org/W2064985699","https://openalex.org/W2080301026","https://openalex.org/W2088476813","https://openalex.org/W2088909125","https://openalex.org/W2098093935","https://openalex.org/W2121995585","https://openalex.org/W2136372495","https://openalex.org/W2138687978","https://openalex.org/W2142666514","https://openalex.org/W2144587057","https://openalex.org/W2154266255","https://openalex.org/W2160456405","https://openalex.org/W2171453022","https://openalex.org/W2339094875","https://openalex.org/W2408820274"],"related_works":["https://openalex.org/W7095242753","https://openalex.org/W2316834752","https://openalex.org/W2137049751","https://openalex.org/W2062627910","https://openalex.org/W1973932789","https://openalex.org/W2359889471","https://openalex.org/W2142053086","https://openalex.org/W1966559901","https://openalex.org/W1966332613","https://openalex.org/W1990944320"],"abstract_inverted_index":{"Activated":[0],"Protein":[1],"C":[2,95,110],"resistance":[3,91,106],"(APCR)":[4],"is":[5,18,25,39,115],"the":[6,26,56,63],"most":[7,27],"frequency":[8],"trombophilia":[9],"that":[10,16,30,85],"induces":[11],"thrombotic":[12],"complications":[13,60,76,124],"of":[14,37,44,73,77,127],"pregnancy":[15,47,78,101,128],"itself":[17],"a":[19,71],"hypercoagulable":[20],"state.":[21],"Abnormal":[22],"placental":[23,123],"vasculature":[24],"important":[28,97],"mechanism":[29],"causes":[31],"various":[32],"complications.":[33,102,129],"The":[34,103],"screening":[35,104],"diagnosis":[36],"APCR":[38],"influenced":[40],"by":[41],"physiological":[42],"changes":[43],"hemostasis":[45],"in":[46,68,117],"and":[48,90],"may":[49],"be":[50],"difficult.":[51],"We":[52,83],"propose":[53],"to":[54,92,107],"evaluate":[55],"risk":[57,98],"for":[58,100,105],"thrombosis":[59],"associated":[61],"with":[62,75,111,121],"factor":[64,86],"V":[65,87],"Leiden":[66,88],"mutation":[67,89],"pregnancy,":[69],"using":[70],"lot":[72],"women":[74,120],"selected":[79],"from":[80],"our":[81],"casuistic.":[82],"concluded":[84],"activated":[93,108],"protein":[94,109],"are":[96],"factors":[99],"FV":[112],"deficiency":[113],"plasma":[114],"recommended":[116],"all":[118],"pregnant":[119],"vascular":[122],"or":[125],"history":[126]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}