{"id":"https://openalex.org/W2408155273","doi":null,"title":"The problem of cardiac valve prostheses, anticoagulants, and pregnancy.","display_name":"The problem of cardiac valve prostheses, anticoagulants, and pregnancy.","publication_year":1984,"publication_date":"1984-09-01","ids":{"openalex":"https://openalex.org/W2408155273","mag":"2408155273","pmid":"https://pubmed.ncbi.nlm.nih.gov/6744561"},"language":"en","primary_location":{"id":"pmid:6744561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6744561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101637575","display_name":"Eduardo J. Salazar","orcid":"https://orcid.org/0000-0003-2136-3823","observed_orcids":["https://orcid.org/0000-0003-2136-3823"]},"institutions":[{"id":"https://openalex.org/I4210106620","display_name":"Instituto Nacional de Cardiologia","ror":"https://ror.org/01fjcgc06","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210106620"]},{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]}],"countries":["BR","MX"],"is_corresponding":false,"raw_author_name":"E Salazar","raw_affiliation_strings":["Instituto Nacional de Cardiologia Ignacio Chavez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Cardiologia Ignacio Chavez","institution_ids":["https://openalex.org/I4210106620","https://openalex.org/I4210157394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027917797","display_name":"Alejandro Zajar\u00edas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Zajarias","raw_affiliation_strings":["Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"N Gutierrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106620","display_name":"Instituto Nacional de Cardiologia","ror":"https://ror.org/01fjcgc06","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210106620"]},{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]}],"countries":["BR","MX"],"is_corresponding":false,"raw_author_name":"N Gutierrez","raw_affiliation_strings":["Instituto Nacional de Cardiologia Ignacio Chavez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Cardiologia Ignacio Chavez","institution_ids":["https://openalex.org/I4210106620","https://openalex.org/I4210157394"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054182908","display_name":"I Iturbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106620","display_name":"Instituto Nacional de Cardiologia","ror":"https://ror.org/01fjcgc06","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210106620"]},{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]}],"countries":["BR","MX"],"is_corresponding":false,"raw_author_name":"I Iturbe","raw_affiliation_strings":["Instituto Nacional de Cardiologia Ignacio Chavez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Cardiologia Ignacio Chavez","institution_ids":["https://openalex.org/I4210106620","https://openalex.org/I4210157394"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5204,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.9618368,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"3 Pt 2","first_page":"I169","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prosthetic-heart-valves","display_name":"prosthetic heart valves","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.8650000095367432},{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.8159999847412109},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.9639999866485596},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.949999988079071},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cerebral-embolism","display_name":"cerebral embolism","score":0.8700000047683716},{"id":"https://openalex.org/keywords/fetal-death","display_name":"fetal death","score":0.7749999761581421},{"id":"https://openalex.org/keywords/bioprosthetic-heart-valves","display_name":"bioprosthetic heart valves","score":0.6970000267028809},{"id":"https://openalex.org/keywords/maternal-fetal-risk","display_name":"maternal and fetal risk","score":0.5580000281333923},{"id":"https://openalex.org/keywords/pregnancy-counseling","display_name":"pregnancy counseling","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9715290069580078},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6786870360374451},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.5911139249801636},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5892587304115295},{"id":"https://openalex.org/C2908892503","wikidata":"https://www.wikidata.org/wiki/Q1339474","display_name":"Maternal death","level":3,"score":0.4936774671077728},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.49109339714050293},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4785100519657135},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4617493450641632},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.4362197518348694},{"id":"https://openalex.org/C2777185221","wikidata":"https://www.wikidata.org/wiki/Q275466","display_name":"Embolism","level":2,"score":0.4314623177051544},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4285874366760254},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34582898020744324},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.11435434222221375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074","descriptor_name":"Acenocoumarol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000074","descriptor_name":"Acenocoumarol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005313","descriptor_name":"Fetal Death","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005313","descriptor_name":"Fetal Death","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008943","descriptor_name":"Mitral Valve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011517","descriptor_name":"Prothrombin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014261","descriptor_name":"Tricuspid Valve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6744561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6744561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Comparative Study"},{"id":"mag:2408155273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6744561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1491720093","https://openalex.org/W17224727","https://openalex.org/W2049256890","https://openalex.org/W2053744213","https://openalex.org/W2413083460","https://openalex.org/W2068882347","https://openalex.org/W2271998366","https://openalex.org/W2058371859","https://openalex.org/W2381281716","https://openalex.org/W2911960045"],"abstract_inverted_index":{"To":[0],"assess":[1],"the":[2,39,50,112,122,126,130,146,200,215,219,225,234],"maternal":[3,139],"and":[4,80,93,129,151,206,218,239],"fetal":[5,204],"risks":[6],"in":[7,18,57,77,82,100,111,115,125,143,155,194,214,244],"patients":[8,56],"with":[9,29,36,162,175],"cardiac":[10,176],"valve":[11,177],"prostheses,":[12],"a":[13,62],"series":[14],"of":[15,53,64,66,72,88,102,134,145,157,199,203,210,222,227,236],"223":[16],"pregnancies":[17,25,150],"156":[19],"women":[20,174,245],"was":[21,32,75,91,98,119],"studied.":[22],"In":[23],"68":[24],"(group":[26,136,160],"I)":[27],"treatment":[28],"antiplatelet":[30,186],"agents":[31,187],"substituted":[33,120],"for":[34,121],"that":[35,87,172],"coumarinics":[37,48,211],"from":[38],"first":[40,127,216],"trimester":[41,128,217],"on.":[42],"Group":[43],"II":[44,84,104],"(128":[45],"pregnancies)":[46],"received":[47,166],"through":[49],"thirty-eighth":[51],"week":[52],"gestation.":[54],"Three":[55],"group":[58,78,83,103],"I":[59,79],"died":[60],"as":[61],"result":[63],"thrombosis":[65],"their":[67],"caged-ball":[68],"valves.":[69],"The":[70],"incidence":[71,202,235],"cerebral":[73,140],"embolism":[74,141],"25.0%":[76],"2.3%":[81],"patients,":[85,196],"while":[86],"spontaneous":[89],"abortion":[90],"10.3%":[92],"28.1%,":[94],"respectively.":[95],"Coumarin":[96],"embryopathy":[97],"found":[99],"7.9%":[101],"infants.":[105],"Fetal":[106],"death":[107,205],"did":[108],"not":[109,189],"occur":[110],"12":[113,156],"cases":[114],"which":[116],"subcutaneous":[117],"heparin":[118,228],"coumarin":[123],"derivative":[124],"last":[131,220],"2":[132],"weeks":[133,221],"pregnancy":[135],"III),":[137],"but":[138],"developed":[142],"8.3%":[144],"patients.":[147],"Finally,":[148],"uneventful":[149],"deliveries":[152],"were":[153],"observed":[154],"15":[158],"mothers":[159],"IV)":[161],"biological":[163],"prostheses":[164,178],"who":[165,246],"no":[167],"anticoagulants.":[168],"It":[169],"is":[170,212],"concluded":[171],"(1)":[173],"should":[179],"be":[180],"counseled":[181],"against":[182,192],"becoming":[183],"pregnant,":[184],"(2)":[185],"do":[188],"provide":[190],"protection":[191],"thromboembolism":[193],"these":[195,230,237],"(3)":[197],"because":[198],"high":[201],"birth":[207],"defects":[208],"use":[209],"contraindicated":[213],"pregnancy,":[223],"(4)":[224],"substitution":[226],"at":[229],"times":[231],"may":[232],"decrease":[233],"complications,":[238],"(5)":[240],"bioprostheses":[241],"are":[242],"indicated":[243],"wish":[247],"to":[248],"bear":[249],"children.":[250]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}