{"id":"https://openalex.org/W2408103287","doi":null,"title":"Histopathological changes in experimental cholera with a non toxigenic non- O1 non-O139 Vibrio cholerae strain isolated from Kolkata, India.","display_name":"Histopathological changes in experimental cholera with a non toxigenic non- O1 non-O139 Vibrio cholerae strain isolated from Kolkata, India.","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2408103287","mag":"2408103287","pmid":"https://pubmed.ncbi.nlm.nih.gov/16538861"},"language":"en","primary_location":{"id":"pmid:16538861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16538861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063570188","display_name":"Dipu Saha","orcid":"https://orcid.org/0000-0001-7089-7878","observed_orcids":["https://orcid.org/0000-0001-7089-7878"]},"institutions":[{"id":"https://openalex.org/I4210101909","display_name":"National Institute of Cholera and Enteric Diseases","ror":"https://ror.org/018azgd14","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210101909"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"D R Saha","raw_affiliation_strings":["National Institute of Cholera & Enteric Diseases P-33, CIT Road, Scheme XM, Kolkata 700 010, India. sahadr@yahoo.co.uk","National Institute of Cholera & Enteric Diseases P-33, CIT Road, Scheme XM, Kolkata 700 010, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Cholera & Enteric Diseases P-33, CIT Road, Scheme XM, Kolkata 700 010, India. sahadr@yahoo.co.uk","institution_ids":["https://openalex.org/I4210101909"]},{"raw_affiliation_string":"National Institute of Cholera & Enteric Diseases P-33, CIT Road, Scheme XM, Kolkata 700 010, India","institution_ids":["https://openalex.org/I4210101909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101413363","display_name":"Amit Pal","orcid":"https://orcid.org/0009-0007-5407-2818","observed_orcids":["https://orcid.org/0009-0007-5407-2818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102707595","display_name":"K. Rajendran","orcid":"https://orcid.org/0000-0002-9898-8883","observed_orcids":["https://orcid.org/0000-0002-9898-8883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Rajendran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110280617","display_name":"P Dutta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Dutta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7008,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.66181818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"44","issue":"3","first_page":"221","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-o1-non-o139-vibrio-cholerae","display_name":"non-O1/non-O139 Vibrio cholerae","score":0.9610000252723694},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hemorrhagic-enteritis","display_name":"hemorrhagic enteritis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/inflammatory-cell-infiltration","display_name":"inflammatory cell infiltration","score":0.8140000104904175},{"id":"https://openalex.org/keywords/enteric-neurons","display_name":"enteric neurons","score":0.7670000195503235},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2778643871","wikidata":"https://www.wikidata.org/wiki/Q160821","display_name":"Vibrio cholerae","level":3,"score":0.8366605043411255},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7390446662902832},{"id":"https://openalex.org/C2780722889","wikidata":"https://www.wikidata.org/wiki/Q12090","display_name":"Cholera","level":2,"score":0.7249151468276978},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.6775088310241699},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.63185054063797},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5964810848236084},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.5525085926055908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5497270226478577},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4855782389640808},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4634757936000824},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4546045660972595},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.41940224170684814},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34598779678344727},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3321409225463867},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.31348156929016113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20708659291267395},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10712176561355591},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0927639901638031},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002771","descriptor_name":"Cholera","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002771","descriptor_name":"Cholera","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D002771","descriptor_name":"Cholera","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014734","descriptor_name":"Vibrio cholerae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D014734","descriptor_name":"Vibrio cholerae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16538861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16538861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},{"id":"mag:2408103287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16538861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1501353922","https://openalex.org/W1577011066","https://openalex.org/W1860453813","https://openalex.org/W1878688220","https://openalex.org/W1933935340","https://openalex.org/W1959617663","https://openalex.org/W1986083162","https://openalex.org/W1997898391","https://openalex.org/W2000197092","https://openalex.org/W2011122897","https://openalex.org/W2027237838","https://openalex.org/W2097359027","https://openalex.org/W2108301297","https://openalex.org/W2108993526","https://openalex.org/W2116286111","https://openalex.org/W2120782801","https://openalex.org/W2122672445","https://openalex.org/W2131058836","https://openalex.org/W2140096935","https://openalex.org/W2153707526","https://openalex.org/W2168354494","https://openalex.org/W2318763602","https://openalex.org/W2397038074","https://openalex.org/W2417296534"],"related_works":["https://openalex.org/W1546924902","https://openalex.org/W2271557330","https://openalex.org/W2168354494","https://openalex.org/W2015193273","https://openalex.org/W2127744635","https://openalex.org/W2279317318","https://openalex.org/W2468155848","https://openalex.org/W2111924435","https://openalex.org/W2585150359","https://openalex.org/W2395390199"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,38,53,111],"conducted":[3],"to":[4,57],"understand":[5],"the":[6,16,42,49,63,67,79,88,91,95,107,118,132,138,152,160,165,170,176],"pathophysiological":[7],"changes":[8],"in":[9,30,40,86,114,117,131,159,174,179],"experimental":[10],"rabbit":[11,46],"ileal":[12,133],"loop":[13],"model":[14,47,121],"using":[15],"Vibrio":[17],"cholerae":[18],"strain":[19,50,182],"non-O1non-O139,":[20],"isolated":[21,166],"as":[22,55,135],"sole":[23],"pathogen":[24],"from":[25,106],"clinically":[26],"diagnosed":[27],"cholera":[28],"patients":[29],"Kolkata.":[31],"Significant":[32],"amount":[33],"of":[34,45,51,62,69,78,90,126,162],"haemorrhagic":[35],"fluid":[36,65],"accumulation":[37],"observed":[39],"all":[41,87],"test":[43],"loops":[44,134],"where":[48],"V.cholerae":[52],"inoculated":[54],"compared":[56],"control":[58],"loops.":[59],"Microscopic":[60],"examination":[61],"accumulated":[64],"showed":[66,123],"presence":[68],"erythrocytes":[70],"and":[71,128,151,164],"pus":[72],"cells.":[73],"Histology":[74],"revealed":[75],"structural":[76],"alteration":[77],"villous":[80],"epithelium":[81],"with":[82,101,137,146],"inflammatory":[83,149],"cells":[84,150],"infiltration":[85],"layers":[89],"gut":[92],"mucosa":[93],"including":[94],"nerve":[96],"plexus":[97],"region.":[98],"Preliminary":[99],"observation":[100],"a":[102],"haemagglutinin":[103],"protease":[104,167],"extracted":[105],"non-O1":[108],"non-O139":[109],"strain,":[110],"also":[112],"studied":[113],"different":[115],"concentrations":[116],"same":[119],"animal":[120],"which":[122],"similar":[124],"type":[125],"macroscopic":[127],"microscopic":[129],"response":[130],"seen":[136],"original":[139],"strain.":[140],"The":[141],"results":[142],"highlight":[143],"that":[144],"along":[145],"other":[147],"pathways,":[148],"enteric":[153],"neurons":[154],"have":[155],"an":[156],"important":[157],"role":[158],"pathophysiology":[161],"diarrhoea":[163],"may":[168],"be":[169],"probable":[171],"virulence":[172],"factor":[173],"initiating":[175],"disease":[177],"process":[178],"this":[180],"non-O1non-O139":[181],"induced":[183],"cholera.":[184]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}