{"id":"https://openalex.org/W2408080321","doi":null,"title":"Elevated DNA polymerase iota (Poli) is involved in the acquisition of aggressive phenotypes of human esophageal squamous cell cancer.","display_name":"Elevated DNA polymerase iota (Poli) is involved in the acquisition of aggressive phenotypes of human esophageal squamous cell cancer.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2408080321","mag":"2408080321","pmid":"https://pubmed.ncbi.nlm.nih.gov/26097541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4466928"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3435147","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4466928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4466928","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044617387","display_name":"Haoyao Sun","orcid":"https://orcid.org/0000-0002-0150-1339","observed_orcids":["https://orcid.org/0000-0002-0150-1339"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyao Sun","raw_affiliation_strings":["Department of Radio-Oncology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radio-Oncology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068512903","display_name":"Shitao Zou","orcid":"https://orcid.org/0000-0001-5147-0975","observed_orcids":["https://orcid.org/0000-0001-5147-0975"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shitao Zou","raw_affiliation_strings":["Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634784","display_name":"Shuyu Zhang","orcid":"https://orcid.org/0000-0003-1419-3635","observed_orcids":["https://orcid.org/0000-0003-1419-3635"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyu Zhang","raw_affiliation_strings":["School of Radiation Medicine and Protection, Medical College of Soochow University Suzhou 215123, Jiangsu, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Radiation Medicine and Protection, Medical College of Soochow University Suzhou 215123, Jiangsu, P. R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Biao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biao Liu","raw_affiliation_strings":["Department of Pathology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090588305","display_name":"Xingjun Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingjun Meng","raw_affiliation_strings":["Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456713","display_name":"Xiaoqing Li","orcid":"https://orcid.org/0000-0002-9815-6040","observed_orcids":["https://orcid.org/0000-0002-9815-6040","https://orcid.org/0009-0002-6630-8529"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqing Li","raw_affiliation_strings":["Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613423","display_name":"Jian Yu","orcid":"https://orcid.org/0000-0001-8449-8739","observed_orcids":["https://orcid.org/0000-0001-8449-8739"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Yu","raw_affiliation_strings":["Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082206594","display_name":"Jinchang Wu","orcid":"https://orcid.org/0000-0002-0786-8529","observed_orcids":["https://orcid.org/0000-0002-0786-8529"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinchang Wu","raw_affiliation_strings":["Department of Radio-Oncology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radio-Oncology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008470213","display_name":"Jundong Zhou","orcid":"https://orcid.org/0000-0002-3752-8728","observed_orcids":["https://orcid.org/0000-0002-3752-8728"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jundong Zhou","raw_affiliation_strings":["Department of Radio-Oncology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China ; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radio-Oncology, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P. R. China ; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital Suzhou 215001, Jiangsu, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2766,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7722585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"8","issue":"4","first_page":"3591","last_page":"601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-iota","display_name":"DNA polymerase iota","score":0.9829999804496765},{"id":"https://openalex.org/keywords/poli","display_name":"Poli","score":0.46000000834465027},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6899999976158142},{"id":"https://openalex.org/keywords/clonogenicity","display_name":"clonogenicity","score":0.5720000267028809},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6321320533752441},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.595113217830658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5637037754058838},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.5552915930747986},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5379559993743896},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4845213294029236},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46019721031188965},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4431925415992737},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4203493297100067},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4080176055431366},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3424970209598541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17656564712524414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1046762764453888},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077277","descriptor_name":"Esophageal Squamous Cell Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094769","descriptor_name":"DNA Polymerase iota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3435147","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4466928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26097541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26097541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4466928","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4466928/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:2408080321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26097541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3435147","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4466928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W56168888","https://openalex.org/W151714794","https://openalex.org/W1908705633","https://openalex.org/W1972598936","https://openalex.org/W1973207486","https://openalex.org/W1995319809","https://openalex.org/W1996613664","https://openalex.org/W2006349852","https://openalex.org/W2006470414","https://openalex.org/W2022752668","https://openalex.org/W2025661917","https://openalex.org/W2032326904","https://openalex.org/W2055749910","https://openalex.org/W2064076994","https://openalex.org/W2080232352","https://openalex.org/W2105707275","https://openalex.org/W2106787323","https://openalex.org/W2111986605","https://openalex.org/W2112979110","https://openalex.org/W2122219557","https://openalex.org/W2126597686","https://openalex.org/W2129036353","https://openalex.org/W2129353670","https://openalex.org/W2136049586","https://openalex.org/W2136369251","https://openalex.org/W2152950651","https://openalex.org/W4238820556","https://openalex.org/W4239358484"],"related_works":["https://openalex.org/W2496296489","https://openalex.org/W2340754995","https://openalex.org/W1995319809","https://openalex.org/W2755421182","https://openalex.org/W3186796564","https://openalex.org/W256076207","https://openalex.org/W4392135713","https://openalex.org/W598583023","https://openalex.org/W1981389501","https://openalex.org/W2367127768"],"abstract_inverted_index":{"DNA":[0,9],"polymerase":[1],"iota":[2],"(Pol\u03b9)":[3],"can":[4],"repair":[5],"several":[6],"types":[7],"of":[8,40,68,85,102,117,156,174,176],"damage":[10],"but":[11],"has":[12],"extremely":[13],"low":[14],"fidelity.":[15],"Previous":[16],"studies":[17],"have":[18],"shown":[19],"an":[20,105],"aberrantly":[21],"elevated":[22],"Pol\u03b9":[23,41,53,69,86,118,148,157,168],"expression":[24,54,155],"in":[25,42,57,94,119,147,171],"human":[26,95,177],"esophageal":[27,43,58,96,178],"squamous":[28,97,179],"cell":[29,98,107,142,180],"cancer":[30,44,59,99,123],"tissues.":[31],"However,":[32],"there":[33],"were":[34],"few":[35],"reports":[36],"describing":[37],"the":[38,172],"role":[39],"progression.":[45],"Based":[46],"on":[47],"Real-time":[48],"PCR":[49],"assay,":[50],"we":[51],"found":[52,111],"was":[55,70,110,145],"up-regulated":[56],"tissues":[60,65],"compared":[61],"to":[62,72,112],"adjacent":[63],"normal":[64],"and":[66,78,91,122,133,163],"overexpression":[67,84],"correlated":[71],"lymph":[73],"node":[74],"metastasis.":[75],"Clonogenic":[76],"assay":[77,81],"transwell":[79],"chamber":[80],"showed":[82,140],"that":[83,116,141,154,167],"had":[87],"higher":[88],"clongenic":[89],"capability":[90],"invasive":[92],"tendency":[93],"cells.":[100,150],"Expression":[101],"cyclin":[103],"D1,":[104],"important":[106],"cycle":[108,143],"regulator,":[109],"be":[113],"associated":[114],"with":[115,160],"tissue":[120],"samples":[121],"cells":[124],"as":[125],"analyzed":[126],"by":[127],"real-time":[128],"PCR,":[129],"immunohistochemistry,":[130],"Western":[131],"blotting":[132],"immunofluorescence":[134],"assay.":[135],"Flow":[136],"cytometry":[137],"analysis":[138],"further":[139],"distribution":[144],"altered":[146],"overexpressing":[149],"These":[151],"results":[152],"indicated":[153],"correlates":[158],"significantly":[159],"tumor":[161],"proliferation":[162],"invasion.":[164],"We":[165],"conclude":[166],"is":[169],"involved":[170],"degree":[173],"aggressiveness":[175],"cancer.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}