{"id":"https://openalex.org/W2408010643","doi":null,"title":"[Preclinical trials for mastering intracytoplasmic injection of a sole spermatozoid for the treatment of male infertility].","display_name":"[Preclinical trials for mastering intracytoplasmic injection of a sole spermatozoid for the treatment of male infertility].","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W2408010643","mag":"2408010643","pmid":"https://pubmed.ncbi.nlm.nih.gov/7627280"},"language":"fr","primary_location":{"id":"pmid:7627280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7627280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contraception, fertilite, sexualite (1992)","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104057293","display_name":"Marc Van den Bergh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M Van den Bergh","raw_affiliation_strings":["Laboratoire FIV, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Belgique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire FIV, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, Belgique","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002734974","display_name":"Edouard Bertrand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Bertrand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081883377","display_name":"Isabelle Govaerts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Govaerts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076424268","display_name":"I. Koenig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Koenig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004082398","display_name":"Jamila Biramane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Biramane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073327731","display_name":"Y Englert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Englert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.28607797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"6","first_page":"393","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.2565999925136566,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.9139999747276306},{"id":"https://openalex.org/keywords/oocyte-damage","display_name":"oocyte damage","score":0.8090000152587891},{"id":"https://openalex.org/keywords/fertilization-rate","display_name":"fertilization rate","score":0.9240000247955322},{"id":"https://openalex.org/keywords/embryo-implantation-rate","display_name":"embryo implantation rate","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pregnancy-rate","display_name":"pregnancy rate","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mesa","display_name":"MESA","score":0.4650000035762787},{"id":"https://openalex.org/keywords/cryopreserved-embryos","display_name":"cryopreserved embryos","score":0.625},{"id":"https://openalex.org/keywords/fertilization-failure","display_name":"fertilization failure","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2778278907","wikidata":"https://www.wikidata.org/wiki/Q28700","display_name":"Intracytoplasmic sperm injection","level":4,"score":0.8290375471115112},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.8275467157363892},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.6032643914222717},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5902778506278992},{"id":"https://openalex.org/C2776537878","wikidata":"https://www.wikidata.org/wiki/Q7239894","display_name":"Pregnancy rate","level":3,"score":0.5642684698104858},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5155922770500183},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.5108201503753662},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5062836408615112},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4748977720737457},{"id":"https://openalex.org/C2776632385","wikidata":"https://www.wikidata.org/wiki/Q74560","display_name":"Spermatozoon","level":3,"score":0.4286479353904724},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.37738358974456787},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.36561793088912964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3224380612373352},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10652968287467957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007317","descriptor_name":"Insemination, Artificial, Homologous","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007318","descriptor_name":"Inservice Training","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015044","descriptor_name":"Zona Pellucida","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7627280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7627280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contraception, fertilite, sexualite (1992)","raw_type":"Clinical Trial"},{"id":"mag:2408010643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7627280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2015034546","https://openalex.org/W2353404449","https://openalex.org/W92049275","https://openalex.org/W2049503427","https://openalex.org/W2460705800","https://openalex.org/W2390398634","https://openalex.org/W7101220206","https://openalex.org/W2024672766","https://openalex.org/W4289048818","https://openalex.org/W2022275862"],"abstract_inverted_index":{"Before":[0],"starting":[1,214],"with":[2,18,102,188,215,242],"the":[3,53,90,95,121,124,129,154],"clinical":[4,216,228],"application":[5],"of":[6,52,120,176,240],"ICS,":[7],"aged":[8,208],"unfertilized":[9,209],"oocytes":[10,63,210],"were":[11,16,68,73,107,179,197],"gathered":[12],"for":[13,30,70],"training":[14,58],"and":[15,139,151,163,167,186,226,235],"injected":[17,54],"a":[19,24,27],"single":[20],"sperm":[21],"or":[22],"without":[23],"spermatozoon":[25],"as":[26,35,37,218],"control":[28],"group":[29,156],"activation.":[31],"Oocyte":[32],"damage,":[33],"initially":[34],"high":[36,219,233],"40%":[38],"was":[39,148,158,172],"reduced":[40,225],"to":[41,89,115,137],"15%":[42],"after":[43,184],"60":[44],"oocytes.":[45,55],"Normal":[46],"fertilization":[47,111,157,170,234],"(2PN)":[48],"occurred":[49],"in":[50,76,94,100,128,238],"18%":[51],"After":[56],"this":[57,251],"period":[59],"1,488":[60],"metaphase":[61],"II":[62],"collected":[64],"during":[65,123],"144":[66],"cycles":[67,122],"used":[69],"ICSI.":[71],"Results":[72,97],"split":[74],"up":[75],"3":[77],"periods":[78],"(n":[79,104],"=":[80,83,86,105],"55,":[81],"n":[82,85],"24,":[84],"57)":[87],"corresponding":[88],"different":[91],"improvements":[92],"made":[93],"technique.":[96,253],"form":[98],"ICSI":[99],"combination":[101],"MESA":[103,155,185],"6)":[106],"analysed":[108],"separately.":[109],"Mean":[110],"increased":[112],"from":[113,135],"24%":[114],"77%.":[116],"Fertilization":[117],"failures":[118],"(18%":[119],"first":[125],"period)":[126],"vanished":[127],"last":[130],"period.":[131],"Implantation":[132],"rate":[133,144,161,165],"improved":[134],"7.4%":[136],"11.4%":[138],"reached":[140],"finally":[141],"26%.":[142],"Pregnancy":[143],"per":[145],"oocyte":[146,221],"retrieval":[147],"16%,":[149],"25%":[150],"54%.":[152],"For":[153],"28%,":[159],"implantation":[160],"17%":[162],"pregnancy":[164,236],"33%":[166],"only":[168],"one":[169],"failure":[171],"observed.":[173],"A":[174],"total":[175],"50":[177],"pregnancies":[178,201],"obtained":[180,183],"including":[181],"2":[182,187],"cryopreserved":[189],"embryos.":[190],"Four":[191],"healthy":[192],"children":[193],"are":[194,202],"born,":[195],"9":[196],"early":[198],"abortions,":[199],"37":[200],"still":[203],"on-going.":[204],"Preclinical":[205],"practice":[206],"on":[207],"seems":[211],"useful":[212],"before":[213],"ICSI,":[217],"initial":[220],"damage":[222],"could":[223],"be":[224],"subsequent":[227],"treatment":[229],"successfully":[230],"applied.":[231],"Offering":[232],"rates":[237],"cases":[239],"infertility":[241],"severe":[243],"male":[244],"factor":[245],"it":[246],"is":[247],"extremely":[248],"worthwhile":[249],"mastering":[250],"new":[252]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
