{"id":"https://openalex.org/W2407977249","doi":null,"title":"Contribution of Somatic and Dendritic SK Channels in the Firing Rate of Deep Cerebellar Nuclei: Implication in Cerebellar Ataxia.","display_name":"Contribution of Somatic and Dendritic SK Channels in the Firing Rate of Deep Cerebellar Nuclei: Implication in Cerebellar Ataxia.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2407977249","mag":"2407977249","pmid":"https://pubmed.ncbi.nlm.nih.gov/27303600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4892332"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3871816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4892332","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4892332","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102965223","display_name":"Samira Abbasi","orcid":"https://orcid.org/0000-0001-6572-8711","observed_orcids":["https://orcid.org/0000-0001-6572-8711"]},"institutions":[{"id":"https://openalex.org/I107853901","display_name":"Sahand University of Technology","ror":"https://ror.org/03wdrmh81","country_code":"IR","type":"education","lineage":["https://openalex.org/I107853901"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Samira Abbasi","raw_affiliation_strings":["Computational Neuroscience Laboratory, Department of Biomedical Engineering, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Neuroscience Laboratory, Department of Biomedical Engineering, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran","institution_ids":["https://openalex.org/I107853901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084494552","display_name":"Ataollah Abbasi","orcid":"https://orcid.org/0000-0001-8406-8587","observed_orcids":["https://orcid.org/0000-0001-8406-8587"]},"institutions":[{"id":"https://openalex.org/I41832843","display_name":"University of Tabriz","ror":"https://ror.org/01papkj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I41832843"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ataollah Abbasi","raw_affiliation_strings":["Department of Mechatronics, School of Engineering Technologies, University of Tabriz, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechatronics, School of Engineering Technologies, University of Tabriz, Tabriz, Iran","institution_ids":["https://openalex.org/I41832843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037275437","display_name":"Yashar Sarbaz","orcid":"https://orcid.org/0000-0002-6258-9653","observed_orcids":["https://orcid.org/0000-0002-6258-9653"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Yashar Sarbaz","raw_affiliation_strings":["Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085837100","display_name":"Parviz Shahabi","orcid":"https://orcid.org/0000-0001-5594-5544","observed_orcids":["https://orcid.org/0000-0001-5594-5544"]},"institutions":[{"id":"https://openalex.org/I107853901","display_name":"Sahand University of Technology","ror":"https://ror.org/03wdrmh81","country_code":"IR","type":"education","lineage":["https://openalex.org/I107853901"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parviz Shahabi","raw_affiliation_strings":["Computational Neuroscience Laboratory, Department of Biomedical Engineering, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Neuroscience Laboratory, Department of Biomedical Engineering, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran","institution_ids":["https://openalex.org/I107853901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5121,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63598753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"1","first_page":"57","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-cerebellar-nuclei","display_name":"deep cerebellar nuclei","score":0.8539999723434448},{"id":"https://openalex.org/keywords/small-conductance-calcium-activated-potassium-channels","display_name":"small conductance calcium-activated potassium channels","score":0.968999981880188},{"id":"https://openalex.org/keywords/cerebellar-ataxia","display_name":"cerebellar ataxia","score":0.9190000295639038},{"id":"https://openalex.org/keywords/neuronal-firing-rate","display_name":"neuronal firing rate","score":0.8600000143051147},{"id":"https://openalex.org/keywords/afterhyperpolarization","display_name":"afterhyperpolarization","score":0.8640000224113464},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7169004082679749},{"id":"https://openalex.org/C2780148635","wikidata":"https://www.wikidata.org/wiki/Q154709","display_name":"Cerebellar ataxia","level":3,"score":0.6159951090812683},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6059019565582275},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.522452712059021},{"id":"https://openalex.org/C2778472085","wikidata":"https://www.wikidata.org/wiki/Q1570272","display_name":"Purkinje cell","level":3,"score":0.49181631207466125},{"id":"https://openalex.org/C2775845787","wikidata":"https://www.wikidata.org/wiki/Q5250377","display_name":"Deep cerebellar nuclei","level":4,"score":0.4670414328575134},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.4479387402534485},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.43823644518852234},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.25800347328186035},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.20642372965812683},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:3871816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4892332","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4892332","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4892332","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Clin Neurosci","raw_type":"Text"},{"id":"pmid:27303600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27303600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic and clinical neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:719015f1b89d428d98da829893a10c72","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/719015f1b89d428d98da829893a10c72","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 7, Iss 1, Pp 57-62 (2016)","raw_type":"article"},{"id":"mag:2407977249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27303600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3871816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4892332","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1510148946","https://openalex.org/W1567568235","https://openalex.org/W1992798574","https://openalex.org/W2005164092","https://openalex.org/W2013380793","https://openalex.org/W2037587275","https://openalex.org/W2062977022","https://openalex.org/W2073500023","https://openalex.org/W2108844680","https://openalex.org/W2109335291","https://openalex.org/W2113734421","https://openalex.org/W2117120818","https://openalex.org/W2126403492","https://openalex.org/W2133031138","https://openalex.org/W2138768371","https://openalex.org/W2143570725","https://openalex.org/W2283057741","https://openalex.org/W2523300383","https://openalex.org/W4234468592"],"related_works":["https://openalex.org/W2037587275","https://openalex.org/W2126403492","https://openalex.org/W7096953560","https://openalex.org/W2404700573","https://openalex.org/W2113734421","https://openalex.org/W1965854108","https://openalex.org/W2079131863","https://openalex.org/W2143570725","https://openalex.org/W2298095409","https://openalex.org/W3017619760"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Loss":[1],"of":[2,11,24,33,51,59,69,75,86,103,120,138,148,186,217,242],"inhibitory":[3],"output":[4],"from":[5],"Purkinje":[6],"cells":[7],"leads":[8],"to":[9,112,193,211,261],"hyperexcitability":[10],"the":[12,49,57,114,117,129,145,190,194,201,240],"Deep":[13],"Cerebellar":[14],"Nuclei":[15],"(DCN),":[16],"which":[17,35],"results":[18,134,180],"in":[19,47,72,116,128,200,220,248],"cerebellar":[20,38,60,224,236],"ataxia.":[21,39,61,237],"Also,":[22],"inhibition":[23,216],"small-conductance":[25],"calcium-activated":[26],"potassium":[27],"(SK)":[28],"channel":[29,42,143,219,228],"increases":[30],"firing":[31,79,94,118,146,196,208],"rate":[32,80,147,209],"DCN,":[34],"could":[36,245],"cause":[37,223],"Therefore,":[40,215],"SK":[41,70,142,159,187,198,218,227,243,252,263],"activators":[43],"can":[44,222,230,254],"be":[45,246,255],"effective":[46,258],"reducing":[48],"symptoms":[50],"this":[52,63,98],"disease,":[53],"and":[54,140,161,164,172,226],"used":[55],"for":[56],"treatment":[58],"In":[62,97,150,238],"regard,":[64],"we":[65],"hypothesized":[66],"that":[67,136],"blockade":[68,137],"channels":[71,88,188,199,244,253],"different":[73,82,90],"compartments":[74],"DCN":[76,104,121,195,221],"would":[77],"increase":[78],"with":[81,157],"value.":[83],"The":[84,132,178],"location":[85,241],"these":[87],"has":[89],"effects":[91],"on":[92,189,207,235],"increasing":[93],"rate.":[95,197],"METHODS:":[96],"study,":[99],"multi-compartment":[100],"computational":[101,108],"model":[102],"was":[105],"used.":[106],"This":[107],"stimulation":[109],"allowed":[110],"us":[111],"study":[113],"changes":[115],"activity":[119],"neuron":[122],"without":[123],"concerns":[124],"about":[125],"interfering":[126],"parameters":[127],"experiment.":[130],"RESULTS:":[131],"simulation":[133,179],"demonstrated":[135],"somatic":[139,262],"dendritic":[141,191],"increased":[144,156],"DCN.":[149],"addition,":[151,239],"after":[152],"hyperpolarization":[153],"(AHP)":[154],"amplitude":[155,171],"blocking":[158],"channel,":[160],"its":[162],"regularity":[163],"resting":[165],"potential":[166],"changed.":[167],"However,":[168],"action":[169],"potentials":[170],"duration":[173],"had":[174],"no":[175],"significant":[176,184],"changes.":[177],"illustrated":[181],"a":[182,232,256],"more":[183,205,257],"contribution":[185],"tree":[192],"proximal":[202],"dendrites":[203],"have":[204,231],"impact":[206],"compared":[210,260],"distal":[212],"dendrites.":[213],"DISCUSSION:":[214],"ataxia,":[225],"openers":[229],"therapeutic":[233,249],"effect":[234],"important":[247],"goals.":[250],"Dendritic":[251],"target":[259],"channels.":[264]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}