{"id":"https://openalex.org/W2407578413","doi":null,"title":"Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein.","display_name":"Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein.","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W2407578413","mag":"2407578413","pmid":"https://pubmed.ncbi.nlm.nih.gov/8877093"},"language":"en","primary_location":{"id":"pmid:8877093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8877093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085094063","display_name":"Roger J. W. Hill","orcid":"https://orcid.org/0000-0002-5049-5473","observed_orcids":["https://orcid.org/0000-0002-5049-5473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Hill","raw_affiliation_strings":["Department of Hematology, SUGEN, Inc., Redwood City, California 94063, USA. Ronald@SUGEN.SF.CA.US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, SUGEN, Inc., Redwood City, California 94063, USA. Ronald@SUGEN.SF.CA.US","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045658012","display_name":"Sergey Zozulya","orcid":"https://orcid.org/0000-0002-1179-2993","observed_orcids":["https://orcid.org/0000-0002-1179-2993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Zozulya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108036700","display_name":"Lu Yin","orcid":"https://orcid.org/0000-0002-4418-6543","observed_orcids":["https://orcid.org/0000-0002-4418-6543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y L Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081175984","display_name":"Paul W. Hollenbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P W Hollenbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001196794","display_name":"Barbara Joyce-Shaikh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Joyce-Shaikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078900428","display_name":"Jakob Bogenberger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Bogenberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016422415","display_name":"Mikhail L. Gishizky","orcid":"https://orcid.org/0000-0002-2704-9790","observed_orcids":["https://orcid.org/0000-0002-2704-9790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Gishizky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3348,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88006305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"9","first_page":"1125","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.3100999891757965,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-mpl","display_name":"c-Mpl","score":0.8510000109672546},{"id":"https://openalex.org/keywords/thrombopoietin","display_name":"thrombopoietin","score":0.968999981880188},{"id":"https://openalex.org/keywords/shc-adaptor-protein","display_name":"Shc adaptor protein","score":0.9629999995231628},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.8640000224113464},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cytokine-receptor-signaling","display_name":"cytokine receptor signaling","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.700472354888916},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6411887407302856},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.637901782989502},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.6137937307357788},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5931304097175598},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5758551955223083},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.562864363193512},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5557650923728943},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5273780822753906},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4690183997154236},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4377361834049225},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42418113350868225},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.4171079993247986},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40625569224357605},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18108195066452026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1531185805797577},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1395987570285797},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0530029833316803},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053628","descriptor_name":"Receptors, Thrombopoietin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8877093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8877093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2407578413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8877093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W50290146","https://openalex.org/W74885494","https://openalex.org/W137528262","https://openalex.org/W173282636","https://openalex.org/W228769658","https://openalex.org/W231599663","https://openalex.org/W1493438883","https://openalex.org/W1577145787","https://openalex.org/W1614661592","https://openalex.org/W1809259025","https://openalex.org/W1954929088","https://openalex.org/W1965375035","https://openalex.org/W1971987125","https://openalex.org/W1984751884","https://openalex.org/W1985368700","https://openalex.org/W1986758681","https://openalex.org/W1995819749","https://openalex.org/W1996093792","https://openalex.org/W1997632886","https://openalex.org/W1997859241","https://openalex.org/W2000269495","https://openalex.org/W2001643449","https://openalex.org/W2011722739","https://openalex.org/W2022261377","https://openalex.org/W2023550672","https://openalex.org/W2024985960","https://openalex.org/W2038818733","https://openalex.org/W2057204569","https://openalex.org/W2065810182","https://openalex.org/W2081185151","https://openalex.org/W2095024459","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2103013787","https://openalex.org/W2112327624","https://openalex.org/W2114918609","https://openalex.org/W2145376670","https://openalex.org/W2154476554","https://openalex.org/W2224708159","https://openalex.org/W2270175648","https://openalex.org/W2272268908","https://openalex.org/W2272820281","https://openalex.org/W2279158789","https://openalex.org/W2288224169","https://openalex.org/W2402366544","https://openalex.org/W2412348981"],"related_works":["https://openalex.org/W869346529","https://openalex.org/W124928854","https://openalex.org/W1966261853","https://openalex.org/W2024141039","https://openalex.org/W2065810182","https://openalex.org/W11710678","https://openalex.org/W4251746109","https://openalex.org/W2034205174","https://openalex.org/W1593199101","https://openalex.org/W2262693853"],"abstract_inverted_index":{"c-Mpl,":[0],"a":[1,35,96,189,269,285],"member":[2],"of":[3,42,61,65,77,87,102,114,123,128,144,147,158,169,179,206,235,249,257,271],"the":[4,85,119,124,148,167,176,195,199,207,215,233,243,250,258,289],"cytokine":[5],"receptor":[6],"superfamily,":[7],"induces":[8],"both":[9],"proliferative":[10,245],"and":[11,99,121,247],"differentiation":[12,28,104,112,217,230,265],"responses":[13],"when":[14,152],"stimulated":[15],"with":[16,27,68,154,161,188,219],"its":[17,282],"ligand":[18,135],"thrombopoietin":[19],"(TPO).":[20],"To":[21,174],"examine":[22],"signal":[23,236,252,272],"transduction":[24,237,253,273],"pathways":[25,238,274],"associated":[26],"versus":[29],"proliferation,":[30],"32D":[31],"clone":[32],"3":[33],"cells,":[34],"murine":[36],"interleukin":[37],"3-(IL-3)-dependent":[38],"cell":[39,93],"line":[40],"capable":[41],"granulocytic":[43,103],"differentiation,":[44,183,277],"were":[45],"engineered":[46],"to":[47,79,134,242,262,276],"express":[48],"human":[49,69],"c-Mpl":[50,182],"(designated":[51],"32DM.2).":[52],"Human":[53],"TPO-containing":[54],"medium":[55],"was":[56,116],"produced":[57],"by":[58,107],"transient":[59],"transfection":[60],"293":[62],"cells.":[63],"Treatment":[64],"32DM.2":[66,81,159,186,212],"cells":[67,82,160,187,213],"TPO":[70,88,115,138,162,216],"induced":[71,140],"cellular":[72,109],"aggregates":[73],"within":[74],"12":[75],"h":[76],"exposure":[78,133],"ligand.":[80],"maintained":[83],"in":[84,92,118,166,181,211,287],"presence":[86,122],"did":[89,163],"not":[90,164],"change":[91],"number":[94],"over":[95],"72-h":[97],"period":[98],"acquired":[100],"characteristics":[101],"as":[105,268,284],"evidenced":[106],"metamyelocytic":[108],"morphology.":[110],"The":[111,255],"effect":[113,221],"observed":[117],"absence":[120],"mitogen":[125],"IL-3.":[126,155],"Evaluation":[127],"protein":[129,150,171,210,261],"tyrosine":[130,145],"phosphorylation":[131,146,168],"following":[132],"revealed":[136],"that":[137,193,228,239],"stimulation":[139],"an":[141],"elevated":[142],"level":[143],"adaptor":[149],"Shc":[151,180,191,267],"compared":[153],"However,":[156],"treatment":[157],"result":[165],"mitogen-activated":[170],"kinase":[172],"(MAPK).":[173],"evaluate":[175],"potential":[177],"role":[178,283],"we":[184],"transfected":[185],"mutant":[190],"gene":[192],"lacked":[194],"region":[196],"coding":[197],"for":[198],"phosphotyrosine":[200],"interaction":[201],"domain":[202],"(delta":[203],"PI-Shc).":[204],"Expression":[205],"delta":[208,259],"PI-Shc":[209,260],"blocked":[214],"response":[218,246],"no":[220],"on":[222],"IL-3-stimulated":[223],"proliferation.":[224],"These":[225],"studies":[226],"demonstrate":[227],"c-Mpl-induced":[229],"results":[231],"from":[232,281],"activation":[234],"are":[240],"dominant":[241],"IL-3":[244],"independent":[248],"Ras/MAPK":[251,290],"pathway.":[254,291],"ability":[256],"block":[263],"TPO-induced":[264],"implicates":[266],"mediator":[270,286],"leading":[275],"which":[278],"is":[279],"distinct":[280],"activating":[288]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
