{"id":"https://openalex.org/W2407565807","doi":null,"title":"Valvular calcification, inflammation, and mortality in dialysis patients.","display_name":"Valvular calcification, inflammation, and mortality in dialysis patients.","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2407565807","mag":"2407565807","pmid":"https://pubmed.ncbi.nlm.nih.gov/24224425"},"language":"en","primary_location":{"id":"pmid:24224425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24224425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052391655","display_name":"Bonita A. Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191209","display_name":"Pennsylvania Hospital","ror":"https://ror.org/03mvdc478","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800191209","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonita A Mohamed","raw_affiliation_strings":["Department of Medicine, Pennsylvania Hospital, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Pennsylvania Hospital, Philadelphia, USA","institution_ids":["https://openalex.org/I2800191209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643710","display_name":"Wei Peter Yang","orcid":"https://orcid.org/0000-0001-8984-4389","observed_orcids":["https://orcid.org/0000-0001-8984-4389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005340751","display_name":"Harold I Litt","orcid":"https://orcid.org/0000-0003-2394-6053","observed_orcids":["https://orcid.org/0000-0003-2394-6053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harold Litt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086540785","display_name":"Sylvia E. Rosas","orcid":"https://orcid.org/0000-0002-9903-4002","observed_orcids":["https://orcid.org/0000-0002-9903-4002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvia E Rosas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.509,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.83579675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"4","first_page":"584","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.12020000070333481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.08860000222921371,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valvular-calcification","display_name":"valve calcification","score":0.9940000176429749},{"id":"https://openalex.org/keywords/coronary-artery-calcification","display_name":"coronary artery calcification","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dialysis-patients","display_name":"dialysis patients","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8460000157356262},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9369999766349792},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8859999775886536},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.765999972820282},{"id":"https://openalex.org/keywords/incident-dialysis","display_name":"incident dialysis","score":0.5910000205039978},{"id":"https://openalex.org/keywords/calcification-progression","display_name":"calcification progression","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9461894035339355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6862497329711914},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6837717890739441},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.6582353711128235},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6384551525115967},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.6132385730743408},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.5578258037567139},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4985847473144531},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.4739682376384735},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34071117639541626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08750608563423157},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.08709332346916199},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006351","descriptor_name":"Heart Valves","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060749","descriptor_name":"alpha-2-HS-Glycoprotein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24224425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24224425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},{"id":"mag:2407565807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24224425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1578143328","display_name":"Coronary calcification in hemodialysis patients","funder_award_id":"R21HL086971","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5052275917","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000040","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2795480987","https://openalex.org/W2170029838","https://openalex.org/W7084127498","https://openalex.org/W2581520983","https://openalex.org/W2102829335","https://openalex.org/W2619834237","https://openalex.org/W4392198654","https://openalex.org/W3015168626","https://openalex.org/W2063744531","https://openalex.org/W3158196364"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM":[2],"OF":[3],"THE":[4],"STUDY:":[5],"The":[6,66,175],"study":[7],"aim":[8],"was":[9,42,70,181,207,226],"to":[10,26,58,99,111,115,165,188],"determine":[11],"the":[12,30,60,149,249],"correlates":[13],"of":[14,32,47,64,103,137,143,151,204,251],"valvular":[15],"calcification":[16,37],"(VC),":[17],"including":[18],"clinical":[19],"and":[20,40,62,114,119,141,190,217,242,261],"physiologic":[21],"parameters,":[22],"in":[23,89,126,183,263],"individuals":[24,51],"new":[25],"dialysis.":[27],"In":[28],"addition,":[29],"association":[31],"VC":[33,94,155,168],"with":[34,93,148,154,195,209,248],"coronary":[35],"artery":[36],"(CAC)":[38],"progression":[39,163,260],"mortality":[41,176,212,262],"investigated.":[43],"METHODS:":[44],"A":[45],"total":[46],"101":[48],"incident":[49,264],"dialysis":[50,265],"underwent":[52],"electrocardiogram-triggered":[53],"multislice":[54],"computed":[55],"tomography":[56],"(CT)":[57],"monitor":[59],"presence":[61,142,150,250],"quantification":[63],"calcification.":[65],"average":[67],"follow":[68],"up":[69],"2.85":[71],"+/-":[72],"0.72":[73],"years.":[74],"RESULTS:":[75],"Twenty-six":[76],"(25.7%)":[77],"patients":[78,184],"had":[79,87,157],"only":[80],"one":[81,196],"valve":[82],"calcified,":[83],"while":[84],"10":[85],"(9.9%)":[86],"calcifications":[88],"both":[90],"valves.":[91,200],"Patients":[92,153],"were":[95,123,145],"older,":[96],"more":[97,109],"likely":[98,110],"have":[100,112],"a":[101,158,210,255],"history":[102,136],"diabetes":[104],"and/or":[105],"cardiovascular":[106],"disease":[107],"(CVD),":[108],"CAC,":[113],"be":[116],"Caucasian;":[117],"fibrinogen":[118],"interleukin-6":[120],"(IL-6)":[121],"levels":[122],"also":[124,156],"higher":[125,159,211],"these":[127],"patients.":[128,266],"Multivariable":[129],"Poisson":[130],"regression":[131],"analysis":[132],"revealed":[133],"older":[134],"age,":[135],"CVD,":[138],"increasing":[139,202],"fibrinogen,":[140],"CAC":[144,162,259],"independently":[146],"associated":[147,208,247],"VC.":[152],"median":[160],"annualized":[161],"compared":[164,187],"those":[166,194],"without":[167,185],"(2.90":[169],"versus":[170],"105.2,":[171],"p":[172,222],"=":[173,223],"0.004).":[174],"rate":[177],"per":[178],"100":[179],"years":[180],"2.57":[182],"VC,":[186,252],"4.20":[189],"13.76,":[191],"respectively,":[192],"for":[193,215,232,258],"or":[197,238],"two":[198],"calcified":[199,205],"An":[201],"number":[203],"valves":[206],"after":[213,230],"adjustment":[214,231],"gender":[216],"race":[218],"[HR":[219],"2.2":[220],"(1.03-4.69),":[221],"0.04],":[224],"but":[225],"not":[227],"statistically":[228],"significant":[229],"inflammatory":[233],"markers":[234],"such":[235],"as":[236],"IL-6":[237],"fibrinogen.":[239],"CONCLUSION:":[240],"Traditional":[241],"novel":[243],"risk":[244,256],"factors":[245],"are":[246],"which":[253],"is":[254],"marker":[257]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}