{"id":"https://openalex.org/W2407564086","doi":null,"title":"Association of Fyn with the activated platelet-derived growth factor receptor: requirements for binding and phosphorylation.","display_name":"Association of Fyn with the activated platelet-derived growth factor receptor: requirements for binding and phosphorylation.","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2407564086","mag":"2407564086","pmid":"https://pubmed.ncbi.nlm.nih.gov/1408131"},"language":"en","primary_location":{"id":"pmid:1408131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1408131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074685249","display_name":"Geraldine M. Twamley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G M Twamley","raw_affiliation_strings":["Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063352954","display_name":"Robert M. Kypta","orcid":"https://orcid.org/0000-0002-2389-310X","observed_orcids":["https://orcid.org/0000-0002-2389-310X"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R M Kypta","raw_affiliation_strings":["European Molecular Biology Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083343107","display_name":"Belinda S. Hall","orcid":"https://orcid.org/0000-0002-3753-1978","observed_orcids":["https://orcid.org/0000-0002-3753-1978"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Hall","raw_affiliation_strings":["European Molecular Biology Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049770940","display_name":"S A Courtneidge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S A Courtneidge","raw_affiliation_strings":["European Molecular Biology Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5758,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.94348445,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"10","first_page":"1893","last_page":"901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fyn","display_name":"Fyn","score":0.7829999923706055},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor-receptor","display_name":"platelet-derived growth factor receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9559999704360962},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.6610000133514404},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.859000027179718},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"autophosphorylation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/yes-kinase","display_name":"Yes kinase","score":0.5759999752044678},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.6539999842643738},{"id":"https://openalex.org/keywords/chimeric-fusion-protein","display_name":"chimeric fusion protein","score":0.6949999928474426},{"id":"https://openalex.org/keywords/baculovirus-expression-system","display_name":"baculovirus expression system","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C37686147","wikidata":"https://www.wikidata.org/wiki/Q423628","display_name":"FYN","level":4,"score":0.9465049505233765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7371596097946167},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.7117301225662231},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.6823926568031311},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6275502443313599},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5952612161636353},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5769757032394409},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.5424723029136658},{"id":"https://openalex.org/C183141693","wikidata":"https://www.wikidata.org/wiki/Q5005962","display_name":"Tyrosine-protein kinase CSK","level":5,"score":0.5359165668487549},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.49808597564697266},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.47494983673095703},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4746328592300415},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4312222898006439},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3987521231174469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2927975058555603},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.2789199650287628},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2782939374446869},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25585827231407166},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.161075621843338}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1408131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1408131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2407564086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1408131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028613968","https://openalex.org/W1989044922","https://openalex.org/W1973365703","https://openalex.org/W7096827975","https://openalex.org/W2047500417","https://openalex.org/W2143406502","https://openalex.org/W1931293178","https://openalex.org/W2257951877","https://openalex.org/W2044610226","https://openalex.org/W4251916233"],"abstract_inverted_index":{"Three":[0],"members":[1],"of":[2,6,37,88,110,117,125,167,172],"the":[3,53,60,79,86,93,96,122,133,145,164,170,183,192,199],"Src":[4],"family":[5],"tyrosine":[7],"kinases":[8,47],"[pp60c-src":[9],"(Src),":[10],"p59fyn":[11],"(Fyn)":[12],"and":[13,19,50,156],"pp62c-yes":[14],"(Yes)]":[15],"are":[16,20],"ubiquitously":[17],"expressed,":[18],"thus":[21],"likely":[22],"to":[23,42,73,114],"have":[24,31,57,67],"general":[25],"roles":[26],"in":[27,83,85,136,151,157,158,182,188],"growth":[28,39],"control.":[29],"We":[30,56],"previously":[32],"shown":[33],"that,":[34],"after":[35],"addition":[36],"platelet-derived":[38],"factor":[40],"(PDGF)":[41],"quiescent":[43],"cells,":[44],"all":[45],"three":[46],"become":[48],"activated":[49,80,184],"associated":[51,143],"with":[52,78,132,144],"PDGF":[54,81,134,146,154,185,193],"receptor.":[55],"now":[58],"addressed":[59],"requirements":[61],"for":[62,129],"this":[63],"association.":[64],"First,":[65],"we":[66,119],"used":[68],"a":[69,115],"baculovirus":[70],"expression":[71],"system":[72],"show":[74],"that":[75,92,121,142,163,191],"Fyn":[76,111,126,168,178],"associates":[77],"receptor":[82,135,147,186,194],"vitro":[84,159],"absence":[87],"other":[89],"proteins,":[90],"demonstrating":[91,190],"association":[94,131],"between":[95],"two":[97],"molecules":[98,108],"is":[99,127],"direct.":[100],"Second,":[101],"by":[102,203],"generating":[103],"cell":[104],"lines":[105],"expressing":[106],"chimeric":[107],"consisting":[109],"sequences":[112],"fused":[113],"portion":[116],"beta-galactosidase,":[118],"found":[120],"SH2":[123],"domain":[124],"necessary":[128],"ligand-stimulated":[130],"vivo.":[137],"Third,":[138],"those":[139],"fusion":[140],"proteins":[141],"also":[148,179],"became":[149,180],"phosphorylated":[150,181],"vivo":[152],"following":[153],"treatment,":[155],"kinase":[160],"assays,":[161],"suggesting":[162],"amino-terminal":[165],"half":[166],"contains":[169],"sites":[171],"PDGF-stimulated":[173],"phosphorylation.":[174],"Partially":[175],"purified,":[176],"kinase-negative":[177],"complex":[187],"vitro,":[189],"phosphorylates":[195],"Fyn,":[196],"rather":[197],"than":[198],"novel":[200],"phosphorylations":[201],"occurring":[202],"autophosphorylation.":[204]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}