{"id":"https://openalex.org/W2407547520","doi":null,"title":"[Molecular biology contributions to wound healing and practical applications].","display_name":"[Molecular biology contributions to wound healing and practical applications].","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2407547520","mag":"2407547520","pmid":"https://pubmed.ncbi.nlm.nih.gov/9931700"},"language":"de","primary_location":{"id":"pmid:9931700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9931700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077079745","display_name":"Sabine Werner","orcid":"https://orcid.org/0000-0001-7397-8710","observed_orcids":["https://orcid.org/0000-0001-7397-8710"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Werner","raw_affiliation_strings":["Max-Planck-Institut f\u00fcr Biochemie, Martinsried"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut f\u00fcr Biochemie, Martinsried","institution_ids":["https://openalex.org/I4210150093"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105364557","display_name":"Barbara Munz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Munz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.36689587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"115","issue":null,"first_page":"678","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratinocyte-growth-factor","display_name":"keratinocyte growth factor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9470000267028809},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.8709999918937683},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/peroxidase","display_name":"peroxidase","score":0.8799999952316284},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9700000286102295},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.7179999947547913},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/skin-damage","display_name":"skin damage","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2778615670","wikidata":"https://www.wikidata.org/wiki/Q3811988","display_name":"Keratinocyte growth factor","level":4,"score":0.8363925218582153},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7834983468055725},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6678211688995361},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5937590599060059},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5730559825897217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5071845054626465},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.4181622266769409},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3657522201538086},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.33891764283180237},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24358990788459778},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1587447226047516},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.13892590999603271},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.10692963004112244}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017468","descriptor_name":"Receptors, Fibroblast Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051497","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051523","descriptor_name":"Fibroblast Growth Factor 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051526","descriptor_name":"Fibroblast Growth Factor 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9931700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9931700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","raw_type":"Journal Article"},{"id":"mag:2407547520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9931700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985337907","https://openalex.org/W2469703074","https://openalex.org/W1984821767","https://openalex.org/W2080716137","https://openalex.org/W2008153386","https://openalex.org/W7134607996","https://openalex.org/W7099427869","https://openalex.org/W1980398407","https://openalex.org/W7100472488","https://openalex.org/W2027150670"],"abstract_inverted_index":{"Keratinocyte":[0],"growth":[1,122],"factor":[2],"(KGF)":[3],"is":[4,11],"a":[5,33,67,78],"potent":[6],"mitogen":[7],"for":[8,49,61],"keratinocytes":[9,99],"which":[10,51,63],"strongly":[12],"expressed":[13],"at":[14],"the":[15,27,40,72,105,117,125],"wound":[16,36,92],"edge":[17],"after":[18],"skin":[19],"injury.":[20],"Inhibition":[21],"of":[22,29,42,57,77,88,119,121],"KGF":[23,43],"receptor":[24],"signalling":[25],"in":[26,35,45,71],"epidermis":[28],"transgenic":[30],"mice":[31],"caused":[32],"delay":[34],"reepithelialization.":[37],"To":[38],"determine":[39],"mechanisms":[41,118],"action":[44,120],"keratinocytes,":[46],"we":[47,64],"searched":[48],"genes":[50,59],"are":[52],"regulated":[53],"by":[54,83],"KGF.":[55,84],"One":[56],"these":[58],"codes":[60],"activin":[62],"identified":[65],"as":[66],"novel":[68,79],"important":[69],"player":[70],"repair":[73,93],"process.":[74,127],"Furthermore,":[75],"expression":[76,86],"peroxidase":[80],"was":[81],"induced":[82],"The":[85],"pattern":[87],"this":[89],"enzyme":[90],"during":[91,104,124],"suggests":[94],"that":[95],"it":[96],"could":[97],"protect":[98],"from":[100],"reactive":[101],"oxygen":[102],"species":[103],"early":[106],"inflammatory":[107],"phase.":[108],"Taken":[109],"together,":[110],"our":[111],"studies":[112],"provide":[113],"new":[114],"insights":[115],"into":[116],"factors":[123],"healing":[126]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}