{"id":"https://openalex.org/W2407418690","doi":"https://doi.org/10.1182/blood.v70.5.1584.1584","title":"Expression of c-abl in Philadelphia-positive acute myelogenous leukemia","display_name":"Expression of c-abl in Philadelphia-positive acute myelogenous leukemia","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W2407418690","doi":"https://doi.org/10.1182/blood.v70.5.1584.1584","mag":"2407418690","pmid":"https://pubmed.ncbi.nlm.nih.gov/3311207"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v70.5.1584.1584","doi":"https://doi.org/10.1182/blood.v70.5.1584.1584","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.5.1584.1584","pdf_url":"https://ashpublications.org/blood/article-pdf/70/5/1584/598658/1584.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/70/5/1584/598658/1584.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016050067","display_name":"Razelle Kurzrock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Kurzrock","raw_affiliation_strings":["Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568613","display_name":"Mordechai Shtalrid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Shtalrid","raw_affiliation_strings":["Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011529063","display_name":"Moshe Talpaz","orcid":"https://orcid.org/0000-0003-3361-3981","observed_orcids":["https://orcid.org/0000-0003-3361-3981"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Talpaz","raw_affiliation_strings":["Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006334042","display_name":"William S. Kloetzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WS Kloetzer","raw_affiliation_strings":["Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037306441","display_name":"J U Gutterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JU Gutterman","raw_affiliation_strings":["Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, M.D. Anderson Hospital and Tumor Institute at Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.3523,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.9593921,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"70","issue":"5","first_page":"1584","last_page":"1588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-abl","display_name":"c-Abl","score":0.8949999809265137},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.9110000133514404},{"id":"https://openalex.org/keywords/22-q34","display_name":"22)(q34","score":0.8949999809265137},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/p210-bcr-abl","display_name":"p210 BCR-ABL","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bcr-rearrangement","display_name":"BCR rearrangement","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tyrosine-kinase-activity","display_name":"tyrosine kinase activity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.795575737953186},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.7671130895614624},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.7375689148902893},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6277751922607422},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.588618278503418},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5884619355201721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5743749737739563},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5446925759315491},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5018596649169922},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.48898589611053467},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.44239747524261475},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2831627130508423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17036467790603638},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12412920594215393},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.10373631119728088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08760365843772888},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.07410481572151184}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010677","descriptor_name":"Philadelphia Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v70.5.1584.1584","doi":"https://doi.org/10.1182/blood.v70.5.1584.1584","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.5.1584.1584","pdf_url":"https://ashpublications.org/blood/article-pdf/70/5/1584/598658/1584.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v70.5.1584.bloodjournal7051584","doi":"https://doi.org/10.1182/blood.v70.5.1584.bloodjournal7051584","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.5.1584.bloodjournal7051584","pdf_url":"https://ashpublications.org/blood/article-pdf/70/5/1584/365590/1584.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:3311207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3311207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1182/blood.v70.5.1584.1584","doi":"https://doi.org/10.1182/blood.v70.5.1584.1584","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.5.1584.1584","pdf_url":"https://ashpublications.org/blood/article-pdf/70/5/1584/598658/1584.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2407418690.pdf","grobid_xml":"https://content.openalex.org/works/W2407418690.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1497321698","https://openalex.org/W1510546584","https://openalex.org/W1610447706","https://openalex.org/W1855564826","https://openalex.org/W1934947469","https://openalex.org/W1969912454","https://openalex.org/W1975812434","https://openalex.org/W1977312224","https://openalex.org/W1994830891","https://openalex.org/W1998593414","https://openalex.org/W2020092689","https://openalex.org/W2040323778","https://openalex.org/W2044496404","https://openalex.org/W2053310263","https://openalex.org/W2060833726","https://openalex.org/W2069169677","https://openalex.org/W2089483984","https://openalex.org/W2106183017","https://openalex.org/W2143952301","https://openalex.org/W2220697339","https://openalex.org/W2287319973","https://openalex.org/W2423786899","https://openalex.org/W2472687946"],"related_works":["https://openalex.org/W2220697339","https://openalex.org/W2039042240","https://openalex.org/W7039839988","https://openalex.org/W2040323778","https://openalex.org/W1497321698","https://openalex.org/W2091722533","https://openalex.org/W2025151479","https://openalex.org/W2410258476","https://openalex.org/W350372407","https://openalex.org/W7099795861"],"abstract_inverted_index":{"The":[0],"identical":[1],"cytogenetic":[2],"marker,":[3],"t(9;22)(q34;q11)":[4],"(Philadelphia":[5],"[Ph]":[6],"translocation),":[7],"is":[8,190],"found":[9,181],"in":[10,93,148,182,198],"approximately":[11],"90%,":[12],"20%,":[13],"and":[14,28,64,80,120,146,189],"2%":[15],"of":[16,55,66,77,82,123,131,150,165,184,201,205,208,215],"adult":[17],"patients":[18],"with":[19,96,108,170],"chronic":[20,221],"myelogenous":[21,30],"leukemia":[22,26,31],"(CML),":[23],"acute":[24,29,217],"lymphoblastic":[25],"(ALL),":[27],"(AML),":[32],"respectively.":[33],"In":[34],"CML,":[35],"the":[36,41,48,56,75,97,100,117,134,141,199,216,220],"molecular":[37],"events":[38],"resulting":[39],"from":[40,59],"Ph":[42],"translocation":[43],"include":[44],"a":[45,83,151,162,195,213],"break":[46,135],"within":[47],"bcr":[49,78,144,157],"locus":[50],"on":[51],"chromosome":[52,60],"22,":[53,63],"transfer":[54],"c-abl":[57],"protooncogene":[58],"9":[61],"to":[62,129,193,211],"formation":[65],"an":[67],"aberrant":[68,85],"210-kD":[69],"bcr-abl":[70],"fusion":[71],"protein":[72,88,154],"(p210bcr-abl).":[73],"Recently,":[74],"absence":[76],"rearrangement":[79],"expression":[81,149],"distinct":[84],"190-kd":[86],"abl":[87,102,153],"(p190c-abl)":[89],"has":[90],"been":[91],"described":[92],"Ph-positive":[94,124,132,222],"ALL,":[95],"suggestion":[98],"that":[99,116,130,177],"two":[101],"variants":[103],"may":[104,138],"be":[105,127,180,212],"pathogenetically":[106],"associated":[107,169],"myeloid":[109,187],"v":[110],"lymphoid":[111,185,202],"leukemogenesis.":[112],"Here":[113],"we":[114],"report":[115],"genomic":[118],"configuration":[119],"translation":[121],"product":[122],"AML":[125],"can":[126,179],"similar":[128],"ALL:":[133],"at":[136],"22q11":[137],"occur":[139],"outside":[140],"5.8":[142],"kb":[143],"region":[145],"result":[147],"190-kD":[152],"lacking":[155],"these":[156],"sequences.":[158],"Phosphokinase":[159],"enzymatic":[160],"activity,":[161],"fundamental":[163],"property":[164],"p210bcr-abl,":[166],"was":[167],"also":[168],"AML-derived":[171],"p190c-abl.":[172],"Our":[173],"current":[174],"observations":[175],"indicate":[176],"p190c-abl":[178,206],"cells":[183],"or":[186],"lineage":[188],"therefore":[191],"unlikely":[192],"play":[194],"specific":[196],"role":[197],"development":[200],"leukemias.":[203],"Formation":[204],"instead":[207],"p210bcr-abl":[209],"appears":[210],"characteristic":[214],"rather":[218],"than":[219],"leukemic":[223],"state.":[224]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}