{"id":"https://openalex.org/W2407304875","doi":null,"title":"Association of TBX2 and P21 expression with clinicopathological features and survival of laryngeal squamous cell carcinoma.","display_name":"Association of TBX2 and P21 expression with clinicopathological features and survival of laryngeal squamous cell carcinoma.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2407304875","mag":"2407304875","pmid":"https://pubmed.ncbi.nlm.nih.gov/25664048","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4307495"},"language":"en","primary_location":{"id":"pmid:25664048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307495/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046546745","display_name":"Yongjiu Huang","orcid":"https://orcid.org/0000-0002-8159-3690","observed_orcids":["https://orcid.org/0000-0002-8159-3690"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yongjiu Huang","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","Department of Otolaryngology Head and Neck Surgery\uff0cBeijing Tongren Hospital\uff0cCapital Medical University\uff0cKey Laboratory of Otolaryngology Head and Neck Surgery\uff08Capital Medical University), Ministry of Education, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I1343551460","https://openalex.org/I183519381","https://openalex.org/I4210122818"]},{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery\uff0cBeijing Tongren Hospital\uff0cCapital Medical University\uff0cKey Laboratory of Otolaryngology Head and Neck Surgery\uff08Capital Medical University), Ministry of Education, Beijing, 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088324664","display_name":"Zufei Li","orcid":"https://orcid.org/0000-0003-0161-3311","observed_orcids":["https://orcid.org/0000-0003-0161-3311"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zufei Li","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","Capital University of Medical Sciences","University of Texas M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I1343551460","https://openalex.org/I183519381","https://openalex.org/I4210122818"]},{"raw_affiliation_string":"Capital University of Medical Sciences","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102016269","display_name":"Qi Zhong","orcid":"https://orcid.org/0000-0003-1259-5200","observed_orcids":["https://orcid.org/0000-0003-1259-5200"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qi Zhong","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","Capital University of Medical Sciences","University of Texas M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I1343551460","https://openalex.org/I183519381","https://openalex.org/I4210122818"]},{"raw_affiliation_string":"Capital University of Medical Sciences","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696676","display_name":"Guojun Li","orcid":"https://orcid.org/0000-0001-9505-1502","observed_orcids":["https://orcid.org/0000-0001-9505-1502"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Guojun Li","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","Head & Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I1343551460","https://openalex.org/I183519381","https://openalex.org/I4210122818"]},{"raw_affiliation_string":"Head & Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052901056","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0003-2797-7535","observed_orcids":["https://orcid.org/0000-0003-2797-7535"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","Capital University of Medical Sciences","University of Texas M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I1343551460","https://openalex.org/I183519381","https://openalex.org/I4210122818"]},{"raw_affiliation_string":"Capital University of Medical Sciences","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100646305","display_name":"Zhigang Huang","orcid":"https://orcid.org/0000-0003-2262-858X","observed_orcids":["https://orcid.org/0000-0003-2262-858X"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210122818","display_name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhigang Huang","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","Capital University of Medical Sciences","University of Texas M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education Beijing 100730, China ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I1343551460","https://openalex.org/I183519381","https://openalex.org/I4210122818"]},{"raw_affiliation_string":"Capital University of Medical Sciences","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"University of Texas M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2606,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77377475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"12","first_page":"5394","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tbx2","display_name":"TBX2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9169999957084656},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8190000057220459},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6579999923706055},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.824999988079071},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8389441967010498},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6593419313430786},{"id":"https://openalex.org/C2910049883","wikidata":"https://www.wikidata.org/wiki/Q852423","display_name":"Laryngeal Neoplasm","level":3,"score":0.6518069505691528},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6380570530891418},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.49658137559890747},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47922924160957336},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4627518653869629},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4505227506160736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43838295340538025},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4234822392463684},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3855578899383545},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34075379371643066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3090548813343048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08850923180580139},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:25664048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4307495","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307495/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:2407304875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4307495","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307495/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1778321542","https://openalex.org/W1981296878","https://openalex.org/W1985306745","https://openalex.org/W1993646208","https://openalex.org/W2015519364","https://openalex.org/W2023081386","https://openalex.org/W2023819452","https://openalex.org/W2032448449","https://openalex.org/W2037611415","https://openalex.org/W2044488139","https://openalex.org/W2050551830","https://openalex.org/W2060305085","https://openalex.org/W2061978928","https://openalex.org/W2067768332","https://openalex.org/W2072207624","https://openalex.org/W2080125477","https://openalex.org/W2089218510","https://openalex.org/W2094127052","https://openalex.org/W2101099235","https://openalex.org/W2101995865","https://openalex.org/W2131597845","https://openalex.org/W2132817913","https://openalex.org/W2137736336","https://openalex.org/W2142575284","https://openalex.org/W2156541342","https://openalex.org/W2156749394","https://openalex.org/W2171335182","https://openalex.org/W2324704321"],"related_works":["https://openalex.org/W2375803360","https://openalex.org/W3150977063","https://openalex.org/W2373769088","https://openalex.org/W1821135556","https://openalex.org/W2466547275","https://openalex.org/W2363275152","https://openalex.org/W2102535440","https://openalex.org/W2342902144","https://openalex.org/W1969162736","https://openalex.org/W2389698167"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,66,91,195],"expression":[2,68,92,107,129,152,175,210,233],"of":[3,70,93,153,211,219,234,247],"P21":[4,75,94,128,141,156,174,193,235],"and":[5,13,29,38,44,56,103,105,116,126,139,155,172,191,208,236],"TBX2":[6,71,106,125,138,154,171,190,237],"in":[7,47,78,238],"laryngeal":[8,18,85],"squamous":[9],"cell":[10],"carcinoma":[11],"(LSCC)":[12],"their":[14,23,42,82],"corresponding":[15],"adjacent":[16,84],"normal":[17],"tissues,":[19],"as":[20,22],"well":[21],"association":[24],"with":[25,81,97,110,123,136,169,186,188,205],"clinical":[26],"pathological":[27],"features":[28],"survival":[30,61,133],"remain":[31],"unclear.":[32],"METHOD:":[33],"we":[34],"used":[35],"the":[36],"RT-PCR":[37],"immunohistochemistry":[39],"to":[40,59],"detect":[41],"mRNA":[43,67],"protein":[45],"levels":[46],"75":[48],"LSCC":[49,79],"patients.":[50],"We":[51],"also":[52],"use":[53],"log-rank":[54],"test":[55],"Cox":[57],"models":[58],"compare":[60],"among":[62],"different":[63],"groups.":[64],"RESULTS:":[65],"level":[69],"was":[72,76,95,108,161,200],"up-regulated,":[73],"while":[74],"down-regulated":[77],"compared":[80,185],"matched":[83],"tissues":[86],"(All":[87,118,144],"P":[88,119,145,158],"<":[89,120,146,159],"0.001).":[90],"correlated":[96],"tumor":[98],"stage,":[99],"lymph":[100,111],"node":[101,112],"metastasis":[102],"smoking;":[104],"associated":[109],"metastasis,":[113],"differentiation":[114],"degree":[115],"smoking":[117],"0.05).":[121,147],"Patients":[122],"high":[124,140,173,192,209],"low":[127,137,170,189,207],"had":[130,177],"significantly":[131,179],"worse":[132],"than":[134,214],"those":[135,187],"expression,":[142],"respectively":[143],"A":[148],"significant":[149],"correlation":[150],"between":[151],"(Pearson,":[157],"0.05)":[160],"observed.":[162],"Furthermore,":[163],"multivariable":[164],"analysis":[165],"showed":[166],"that":[167,231],"patients":[168,204],"alone":[176],"a":[178],"reduced":[180],"risk":[181,196],"for":[182,197,203],"overall":[183,198],"death":[184,199],"expression.":[194],"even":[201],"lower":[202],"both":[206,212,220],"genes":[213,221],"any":[215],"other":[216],"co-expression":[217],"status":[218],"(HR,":[222],"0.1;":[223],"95%":[224],"CI,":[225],"0.0-0.9).":[226],"CONCLUSION:":[227],"These":[228],"results":[229],"suggest":[230],"abnormal":[232],"tumors":[239],"may":[240],"jointly,":[241],"or":[242],"individually,":[243],"predict":[244],"poor":[245],"prognosis":[246],"LSCC.":[248]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}