{"id":"https://openalex.org/W2407223645","doi":null,"title":"GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice.","display_name":"GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2407223645","mag":"2407223645","pmid":"https://pubmed.ncbi.nlm.nih.gov/20944099"},"language":"en","primary_location":{"id":"pmid:20944099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066278415","display_name":"Ming\u2010Hsien Tsai","orcid":"https://orcid.org/0000-0002-7025-6656","observed_orcids":["https://orcid.org/0000-0002-7025-6656"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Hsien Tsai","raw_affiliation_strings":["Graduate Institute of Medicine, Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medicine, Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080333862","display_name":"Ryoichi Aki","orcid":"https://orcid.org/0000-0001-7120-5714","observed_orcids":["https://orcid.org/0000-0001-7120-5714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryoichi Aki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081516321","display_name":"Yasuyuki Amoh","orcid":"https://orcid.org/0000-0002-3522-7868","observed_orcids":["https://orcid.org/0000-0002-3522-7868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuyuki Amoh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113509085","display_name":"Kensei Katsuoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kensei Katsuoka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018349469","display_name":"Hiroaki J. Kimura","orcid":"https://orcid.org/0000-0002-7441-0382","observed_orcids":["https://orcid.org/0000-0002-7441-0382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroaki Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Claudia Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090348824","display_name":"Chung\u2010Hsing Chang","orcid":"https://orcid.org/0000-0003-2197-4923","observed_orcids":["https://orcid.org/0000-0003-2197-4923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chung-Hsing Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3816,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.82268579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"9","first_page":"3291","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.1534000039100647,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.09009999781847,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/uv-c-irradiation","display_name":"UV-C irradiation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"green fluorescent protein","score":0.9190000295639038},{"id":"https://openalex.org/keywords/red-fluorescent-protein","display_name":"red fluorescent protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7279999852180481},{"id":"https://openalex.org/keywords/non-invasive-tumor-imaging","display_name":"non-invasive tumor imaging","score":0.875},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8584192395210266},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.8457791805267334},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5895190834999084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5029906630516052},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.46933308243751526},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.374098002910614},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3580936789512634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3416631519794464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3340202271938324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2716679573059082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07763966917991638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05477637052536011},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D014467","descriptor_name":"Ultraviolet Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20944099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2407223645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1798337468","https://openalex.org/W1967963872","https://openalex.org/W1986728257","https://openalex.org/W1999364789","https://openalex.org/W2032212406","https://openalex.org/W2039854579","https://openalex.org/W2045775611","https://openalex.org/W2047887335","https://openalex.org/W2048648016","https://openalex.org/W2052406653","https://openalex.org/W2066160597","https://openalex.org/W2073447587","https://openalex.org/W2087275709","https://openalex.org/W2097858802","https://openalex.org/W2108447763","https://openalex.org/W2114143448","https://openalex.org/W2121783994","https://openalex.org/W2123049876","https://openalex.org/W2133037612","https://openalex.org/W2147244050","https://openalex.org/W2151922124","https://openalex.org/W2168261379","https://openalex.org/W2169032395"],"related_works":["https://openalex.org/W2314215793","https://openalex.org/W2028187795","https://openalex.org/W2565997482","https://openalex.org/W2907636934","https://openalex.org/W2133037612","https://openalex.org/W2165382073","https://openalex.org/W2316810636","https://openalex.org/W2109674712","https://openalex.org/W2955245865","https://openalex.org/W1546275329"],"abstract_inverted_index":{"Melanoma":[0],"cell":[1],"lines":[2],"that":[3,13,176],"stably":[4],"express":[5,15],"green":[6],"fluorescent":[7,17,170],"protein":[8,18,171],"(GFP)":[9],"and":[10,70,112,123,161],"nude":[11],"mice":[12,56,77,108],"ubiquitously":[14],"red":[16],"(RFP)":[19],"have":[20],"previously":[21],"been":[22],"developed":[23,65],"to":[24],"study":[25],"tumor-host":[26,149],"interaction":[27],"by":[28],"color-coded":[29,148,169],"imaging.":[30,88,172],"In":[31],"the":[32,35,44,52,75,107,129],"present":[33],"study,":[34],"efficacy":[36,157],"of":[37,46,54,106,155],"fluorescence-guided":[38,177],"ultraviolet":[39],"C":[40],"(UVC)":[41],"irradiation":[42,116,133,179],"on":[43,138,158],"growth":[45,122,140,160],"murine":[47],"melanoma":[48,69,90,121,139,159],"expressing":[49,78],"GFP":[50],"in":[51,128],"ear":[53],"RFP":[55,79],"was":[57,91],"determined":[58],"using":[59,86],"a":[60,135,181],"non-invasive":[61,87,168],"ear-tumor":[62],"imaging":[63],"model":[64,150],"previously.":[66],"The":[67,89,104],"GFP-expressing":[68],"RFP-expressing":[71],"blood":[72,126],"vessels":[73,127],"from":[74],"transgenic":[76],"used":[80],"as":[81,141,143],"hosts":[82],"were":[83,109],"readily":[84,165],"visible":[85],"treated":[92],"under":[93],"fluorescence":[94],"guidance":[95],"with":[96,117,167],"UVC":[97,119,132,178],"at":[98],"650":[99],"J/m2/minute":[100],"for":[101,153,185],"3":[102],"minutes.":[103],"ears":[105],"observed":[110],"before":[111],"24":[113],"hours":[114],"after":[115],"UVC.":[118],"inhibited":[120],"also":[124],"damaged":[125],"tumor.":[130],"Thus,":[131],"has":[134],"direct":[136],"effect":[137],"well":[142],"an":[144],"anti-angiogenesis":[145],"effect.":[146],"This":[147],"is":[151,180],"useful":[152],"evaluation":[154],"treatment":[156],"angiogenesis,":[162],"which":[163],"are":[164],"discernable":[166],"These":[173],"results":[174],"suggest":[175],"promising":[182],"therapeutic":[183],"strategy":[184],"melanoma.":[186]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}