{"id":"https://openalex.org/W2407124373","doi":null,"title":"Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53.","display_name":"Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53.","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W2407124373","mag":"2407124373","pmid":"https://pubmed.ncbi.nlm.nih.gov/8361769"},"language":"en","primary_location":{"id":"pmid:8361769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8361769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050026664","display_name":"Albrecht Otto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Otto","raw_affiliation_strings":["Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie, Universit\u00e4t Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut f\u00fcr Experimentelle Virologie und Immunologie, Universit\u00e4t Hamburg, Germany","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091514112","display_name":"Wolfgang Deppert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Deppert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4077,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93736233,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"9","first_page":"2591","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9070000052452087},{"id":"https://openalex.org/keywords/p53-overexpression","display_name":"p53 overexpression","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tumor-suppressor-activity","display_name":"tumor suppressor activity","score":0.5720000267028809},{"id":"https://openalex.org/keywords/tumor-cell-growth-inhibition","display_name":"tumor cell growth inhibition","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.845298171043396},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.8130265474319458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7679330110549927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6546772122383118},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.5414223074913025},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5217600464820862},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5127967000007629},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.437153697013855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4159051179885864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40071019530296326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37165898084640503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17819783091545105},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.11576765775680542}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8361769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8361769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2407124373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8361769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2402625550","https://openalex.org/W4406057410","https://openalex.org/W2144615015","https://openalex.org/W2137124052","https://openalex.org/W2159423695","https://openalex.org/W2005966376","https://openalex.org/W2460485905","https://openalex.org/W2157126713","https://openalex.org/W3030435769","https://openalex.org/W2549240428"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,15,26,29,90,109,116,129,141,155,167,179,190],"mouse":[2,8],"wild-type":[3],"p53":[4,17,40,111,146,158,181,195],"(wt":[5],"p53)":[6],"in":[7,112,119,196],"Meth":[9,58,130],"A":[10,59,131],"tumor":[11,96],"cells":[12,49,62,121,132,161,198],"after":[13],"transfection":[14],"wt":[16,39,46,110,125,145,168,180,194],"encoding":[18],"vectors":[19],"induced":[20],"a":[21,52,87,134,138,152,164,176],"strong":[22],"growth-inhibitory":[23,107],"response.":[24],"Cells":[25],"only":[27],"few":[28],"randomly":[30],"selected":[31],"surviving":[32],"colonies":[33],"contained":[34],"and":[35,74,157,193],"expressed":[36],"the":[37,56,64,72,76,80,106,188],"transfected":[38],"specific":[41],"DNA.":[42],"Despite":[43],"expressing":[44],"authentic":[45],"p53,":[47,91,126],"such":[48],"(MethAp53wt)":[50],"exhibited":[51],"similar":[53],"phenotype":[54],"as":[55,86,127,187],"parental":[57],"cells.":[60,114],"These":[61],"overexpressed":[63],"mdm-2":[65,117,142],"(mouse":[66],"double":[67],"minute-2)":[68],"gene,":[69],"both":[70,191],"at":[71,75],"RNA":[73],"protein":[77,82],"level.":[78],"Recently,":[79],"MDM-2":[81,103,156,192],"has":[83,104],"been":[84],"identified":[85],"cellular":[88],"target":[89],"which":[92],"can":[93],"abolish":[94],"its":[95],"suppressor":[97],"activity.":[98],"We,":[99],"therefore,":[100],"suggest":[101],"that":[102,151],"mitigated":[105],"effect":[108],"MethAp53wt":[113,120,197],"Upregulation":[115],"expression":[118,166],"was":[122,199],"mediated":[123,174],"by":[124,175],"analysis":[128],"carrying":[133],"tsp53":[135],"(p53Val135)":[136],"revealed":[137],"strict":[139],"dependence":[140],"upregulation":[143],"upon":[144],"expression.":[147],"Our":[148],"results":[149],"propose":[150],"balanced":[153],"ratio":[154],"will":[159],"allow":[160],"to":[162,202],"tolerate":[163],"limited":[165],"p53.":[169],"This":[170],"tolerance":[171],"is":[172],"not":[173,200],"direct":[177],"inactivation":[178],"via":[182],"complex":[183],"formation":[184],"with":[185],"MDM-2,":[186],"majority":[189],"complexed":[201],"each":[203],"other.":[204]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}