{"id":"https://openalex.org/W2407098255","doi":null,"title":"Elimination of methyl methanesulfonate (MMS)-induced micronuclei (MNS) under mild hyperthermia via p53-dependent pathway in human lymphoid cells.","display_name":"Elimination of methyl methanesulfonate (MMS)-induced micronuclei (MNS) under mild hyperthermia via p53-dependent pathway in human lymphoid cells.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2407098255","mag":"2407098255","pmid":"https://pubmed.ncbi.nlm.nih.gov/17564316"},"language":"en","primary_location":{"id":"pmid:17564316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17564316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in molecular pathology and pharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111741319","display_name":"Hwa Jin Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hwa Jin Jung","raw_affiliation_strings":["Department of Pharmacology, Medical Research Center (MRC), College of Medicine, Kyung Hee University, Seoul 130-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medical Research Center (MRC), College of Medicine, Kyung Hee University, Seoul 130-701, South Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007870153","display_name":"Jee Na Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jee Na Hwang","raw_affiliation_strings":["[Kyung Hee University]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Kyung Hee University]","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017613692","display_name":"Young Rok Seo","orcid":"https://orcid.org/0000-0002-4093-4073","observed_orcids":["https://orcid.org/0000-0002-4093-4073"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young R Seo","raw_affiliation_strings":["[Kyung Hee University]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Kyung Hee University]","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"115-116","issue":null,"first_page":"175","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyl-methanesulfonate","display_name":"methyl methanesulfonate","score":0.984000027179718},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mild-hyperthermia","display_name":"mild hyperthermia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6470000147819519},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6650000214576721},{"id":"https://openalex.org/keywords/lymphoid-cells","display_name":"lymphoid cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/carcinogenesis-prevention","display_name":"carcinogenesis prevention","score":0.8679999709129333},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chromosomal-stability","display_name":"chromosome stability","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.8492807149887085},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.8486132621765137},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7171856164932251},{"id":"https://openalex.org/C2776900477","wikidata":"https://www.wikidata.org/wiki/Q3077242","display_name":"Methyl methanesulfonate","level":4,"score":0.6849332451820374},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6574224233627319},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6226305365562439},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.6169549822807312},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5873841047286987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4997687339782715},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4945392310619354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33384397625923157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2946510314941406},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28418105840682983},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.16922882199287415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16656413674354553},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008741","descriptor_name":"Methyl Methanesulfonate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015162","descriptor_name":"Micronucleus Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17564316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17564316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in molecular pathology and pharmacology","raw_type":"Journal Article"},{"id":"mag:2407098255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17564316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418757736","https://openalex.org/W3031359031","https://openalex.org/W2107386636","https://openalex.org/W1978232808","https://openalex.org/W2026851393","https://openalex.org/W1968646597","https://openalex.org/W6889237899","https://openalex.org/W2070030787","https://openalex.org/W2978592065","https://openalex.org/W1987803538"],"abstract_inverted_index":{"P53-mediated":[0],"cellular":[1],"response":[2,107],"has":[3],"been":[4,62],"known":[5],"to":[6,32,65,108],"play":[7],"a":[8,113],"crucial":[9],"role":[10,72,116],"in":[11,38,102,106,120,143],"maintaining":[12],"genomic":[13,57],"stability":[14,122],"of":[15,56,73,88,94,96,117,131,135,141],"mammalian":[16],"cells":[17,105],"against":[18,78,123],"genotoxic":[19,124],"stresses.":[20,125],"In":[21],"our":[22],"previous":[23],"study,":[24],"we":[25,83],"showed":[26],"that":[27,47],"mild":[28,48,76,109,118,136],"hyperthermia":[29,49,77,119,137],"was":[30],"sufficient":[31],"induce":[33],"apoptosis":[34],"on":[35,70],"p53-dependent":[36],"pathway":[37],"human":[39,103,145],"lymphoid":[40,104,146],"system":[41],"(Seo":[42],"et":[43],"al.,":[44],"1999),":[45],"suggesting":[46,112],"might":[50,128],"be":[51],"useful":[52],"for":[53,138],"the":[54,67,86,132,139,144],"reducing":[55],"instability.":[58],"However,":[59],"there":[60],"have":[61],"few":[63],"reports":[64],"show":[66,85],"direct":[68],"evidence":[69],"preventive":[71],"p53":[74,100],"under":[75],"carcinogenic":[79,97],"DNA":[80],"damage.":[81],"Here":[82],"first":[84],"elimination":[87],"MMS-induced":[89],"micronuclei":[90],"(MN)":[91],"as":[92],"one":[93],"biomarkers":[95],"risk":[98],"by":[99],"activation":[101],"hyperthermia,":[110],"strongly":[111],"possible":[114],"protective":[115],"chromosomal":[121],"Our":[126],"data":[127],"support":[129],"investigation":[130],"clinical":[133],"application":[134],"prevention":[140],"carcinogenesise":[142],"system.":[147]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}