{"id":"https://openalex.org/W2407066130","doi":null,"title":"Cytotoxic T lymphocyte-associated antigen-4 +49A>G polymorphism and the risk of non-small cell lung cancer in a Chinese population.","display_name":"Cytotoxic T lymphocyte-associated antigen-4 +49A>G polymorphism and the risk of non-small cell lung cancer in a Chinese population.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2407066130","mag":"2407066130","pmid":"https://pubmed.ncbi.nlm.nih.gov/26379973","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4565356"},"language":"en","primary_location":{"id":"pmid:26379973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26379973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4565356/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059346982","display_name":"Hui-Ning Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Ning Liu","raw_affiliation_strings":["Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004864625","display_name":"Jianling Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Ling Su","raw_affiliation_strings":["Department of Emergency, Second Hospital of Hebei Medical University Shijiazhuang 050051, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Second Hospital of Hebei Medical University Shijiazhuang 050051, China","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100553721","display_name":"Shaohui Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao-Hui Zhou","raw_affiliation_strings":["Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350025","display_name":"Lijun Liu","orcid":"https://orcid.org/0009-0000-6912-6611","observed_orcids":["https://orcid.org/0009-0000-6912-6611","https://orcid.org/0000-0001-6920-3066"]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Jun Liu","raw_affiliation_strings":["Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China","institution_ids":["https://openalex.org/I4210110525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048118159","display_name":"Peng Qie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110525","display_name":"Hebei General Hospital","ror":"https://ror.org/01nv7k942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110525"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Qie","raw_affiliation_strings":["Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Hebei General Hospital Shijiazhuang 050051, China","institution_ids":["https://openalex.org/I4210110525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3544,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59491027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"8","issue":"7","first_page":"11519","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.6650000214576721},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ctla-4-gene","display_name":"CTLA-4 gene","score":0.6620000004768372},{"id":"https://openalex.org/keywords/t-cell-regulation","display_name":"T cell regulation","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.779825747013092},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7238037586212158},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.718719482421875},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7096927165985107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6117863655090332},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6005526185035706},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5605150461196899},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5075393915176392},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4892313480377197},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.447199285030365},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.43768221139907837},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42417019605636597},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18618664145469666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11010786890983582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08610385656356812},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:26379973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26379973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4565356","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4565356/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:2407066130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26379973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4565356","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4565356/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1519521580","https://openalex.org/W1752089945","https://openalex.org/W1977369560","https://openalex.org/W1995847336","https://openalex.org/W2012305749","https://openalex.org/W2016302352","https://openalex.org/W2017861959","https://openalex.org/W2035712629","https://openalex.org/W2049365725","https://openalex.org/W2051014690","https://openalex.org/W2063417695","https://openalex.org/W2066639014","https://openalex.org/W2081590238","https://openalex.org/W2090624647","https://openalex.org/W2098668928","https://openalex.org/W2112240302","https://openalex.org/W2134638467","https://openalex.org/W2140460887","https://openalex.org/W2143467222","https://openalex.org/W2149363036","https://openalex.org/W2161817637","https://openalex.org/W2162540156"],"related_works":["https://openalex.org/W2012305749","https://openalex.org/W3148736704","https://openalex.org/W4402246617","https://openalex.org/W2898589430","https://openalex.org/W2751991030","https://openalex.org/W2049365725","https://openalex.org/W2066639014","https://openalex.org/W7095291217","https://openalex.org/W2186542236","https://openalex.org/W1562099147"],"abstract_inverted_index":{"BACKGROUND:":[0],"CTLA-4":[1,25,52,123,227],"is":[2,230],"a":[3,9,61,203],"potent":[4],"immunoregulatory":[5],"molecule":[6],"and":[7,19,28,55,70,99,105,125],"plays":[8],"pivotal":[10],"role":[11],"in":[12,36,60,74,209,237],"the":[13,22,29,49,56,75,84,122,126,132,138,141,158,176,181,199,212,226],"negative":[14],"regulation":[15],"of":[16,31,58,86,128,179,207,235],"T-cell":[17],"proliferation":[18],"activation.":[20],"Previously,":[21],"association":[23,50],"between":[24,51,96,121],"+49A>G":[26,53,228],"polymorphism":[27,54,85,124,229],"risk":[30,57,149,167,189,206,234],"NSCLC":[32,59,68,97,151,169,191,208],"has":[33],"been":[34],"investigated":[35,48],"several":[37],"studies,":[38],"however,":[39,157],"their":[40],"results":[41],"were":[42,112],"inconsistent.":[43],"Therefore,":[44],"we":[45],"aimed":[46],"to":[47,82,93,118],"Chinese":[62,238],"population.":[63,239],"METHODS:":[64],"We":[65],"recruited":[66],"231":[67],"patients":[69,98],"250":[71],"healthy":[72],"controls":[73],"present":[76],"case-control":[77],"study.":[78],"PCR-RFLP":[79],"was":[80,91,135,144,161,184],"used":[81,92,136],"analyze":[83],"CTLA-4.":[87],"The":[88,101],"chi-squared":[89],"test":[90],"examine":[94],"differences":[95],"controls.":[100],"odds":[102],"ratio":[103],"(OR)":[104],"its":[106],"95%":[107,153,171,193,216],"confidence":[108],"interval":[109],"(95%":[110],"CI)":[111],"obtained":[113],"by":[114],"logistic":[115],"regression":[116],"methodology":[117],"determine":[119],"correlations":[120],"incidence":[127],"NSCLC.":[129],"RESULTS:":[130],"When":[131],"AA":[133],"genotype":[134,143,160,183],"as":[137],"reference":[139],"group,":[140],"GG":[142],"significantly":[145,163,185],"associated":[146,164,186,231],"with":[147,165,187,211,232],"increased":[148,166,188,233],"for":[150,168,190],"(OR=2.181,":[152],"CI:":[154,172,194,217],"1.244-5.198;":[155],"P=0.007),":[156],"AG":[159],"not":[162],"(OR=2.018,":[170],"0.826-3.881;":[173],"P=0.099).":[174],"Under":[175],"dominant":[177],"model":[178],"inheritance,":[180],"AG+GG":[182],"(OR=3.271,":[192],"1.827-4.559;":[195],"P=0.015).":[196],"In":[197],"addition,":[198],"G":[200],"allele":[201,214],"had":[202],"2.754-fold":[204],"higher":[205],"comparison":[210],"A":[213],"(OR=2.754,":[215],"1.365-6.891,":[218],"P=0.005).":[219],"CONCLUSIONS:":[220],"Our":[221],"data":[222],"provided":[223],"evidence":[224],"that":[225],"NSLCL":[236]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
