{"id":"https://openalex.org/W2407042003","doi":null,"title":"[Intra-arterial infusion chemotherapy with anticancer agents for advanced breast cancer--effect and toxicity of mitomycin C and adriamycin].","display_name":"[Intra-arterial infusion chemotherapy with anticancer agents for advanced breast cancer--effect and toxicity of mitomycin C and adriamycin].","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W2407042003","mag":"2407042003","pmid":"https://pubmed.ncbi.nlm.nih.gov/2934023"},"language":"ja","primary_location":{"id":"pmid:2934023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2934023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"K Toda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Toda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027825617","display_name":"Kazuaki Asaishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Asaishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089526348","display_name":"Atsushi Okazaki","orcid":"https://orcid.org/0000-0002-4598-0589","observed_orcids":["https://orcid.org/0000-0002-4598-0589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Okazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112105490","display_name":"Y Okazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Okazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109529302","display_name":"M. Okazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Okazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022114207","display_name":"Takahiro Ebata","orcid":"https://orcid.org/0000-0001-9383-2903","observed_orcids":["https://orcid.org/0000-0001-9383-2903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ebata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081684987","display_name":"Morio TOTSUKA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Totsuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016844099","display_name":"Hiroshi Hayasaka","orcid":"https://orcid.org/0000-0001-6358-7070","observed_orcids":["https://orcid.org/0000-0001-6358-7070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hayasaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103697607","display_name":"Noriyuki Sato","orcid":"https://orcid.org/0000-0002-6202-2104","observed_orcids":["https://orcid.org/0000-0002-6202-2104","https://orcid.org/0009-0001-9418-0238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Sato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113469103","display_name":"Eichi Narimatsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Narimatsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"12","first_page":"2298","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intra-arterial-infusion-chemotherapy","display_name":"arterial infusion chemotherapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.7440000176429749},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histological-response","display_name":"histological response","score":0.6340000033378601},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2909463153","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukocytopenia","level":3,"score":0.9250114560127258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8614459037780762},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.7398204207420349},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6808481216430664},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5886503458023071},{"id":"https://openalex.org/C2776581026","wikidata":"https://www.wikidata.org/wiki/Q864868","display_name":"Bone marrow suppression","level":3,"score":0.5787051320075989},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5025599002838135},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49391061067581177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48048391938209534},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4706415832042694},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46753284335136414},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.44802340865135193},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4250043034553528},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.4108580946922302},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4092106819152832},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3233659267425537},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2740786373615265},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.234171062707901}],"mesh":[{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003875","descriptor_name":"Drug Eruptions","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008937","descriptor_name":"Mitomycins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008937","descriptor_name":"Mitomycins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2934023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2934023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},{"id":"mag:2407042003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2934023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2404958714","https://openalex.org/W2464940758","https://openalex.org/W2414965968","https://openalex.org/W2053629159","https://openalex.org/W2132584554","https://openalex.org/W2052281493","https://openalex.org/W2017172827","https://openalex.org/W2056248482","https://openalex.org/W2047574625","https://openalex.org/W1982178920"],"abstract_inverted_index":{"In":[0,86],"23":[1],"cases":[2,105,166],"of":[3,11,150,158,163,172,188,199],"primary":[4,136],"advanced":[5,137],"breast":[6,138],"cancer,":[7],"intra-arterial":[8,141],"infusion":[9,142],"chemotherapy":[10,143],"Adriamycin":[12],"(ADR)":[13],"and":[14,26,29,49,66,83,115,119],"Mitomycin":[15],"C":[16],"(MMC),":[17],"which":[18],"were":[19,32,76],"injected":[20],"jointly":[21],"or":[22],"individually,":[23],"was":[24,45,58,94,117,175,183],"performed":[25],"its":[27],"effects":[28,31,190],"side":[30,101],"studied.":[33],"As":[34,98],"for":[35,99,135],"the":[36,39,50,90,100,104,131,164,169,173,180,186,189,197],"clinical":[37,82],"effects,":[38,102],"response":[40,52,92],"rate":[41,53,93],"(CR":[42],"+":[43,70],"PR)":[44],"73.9%":[46],"(17/23":[47],"cases)":[48],"histological":[51,84,91],"(greater":[54],"than":[55,179],"grade":[56,187],"IIb)":[57],"82.6%":[59],"(19/23":[60],"cases).":[61,97],"ADR":[62,71,145],"alone":[63],"(100-150":[64],"mg)":[65,69,73],"MMC":[67],"(28":[68],"(42":[72],"combined":[74],"regimens":[75],"especially":[77],"superior":[78],"in":[79,103,147],"both":[80],"their":[81],"effects.":[85],"metastatic":[87],"lymph":[88],"nodes,":[89],"78.9%":[95],"(15/19":[96],"treated":[106],"with":[107],"MMC,":[108],"bone":[109],"marrow":[110],"suppression":[111],"such":[112],"as":[113],"leukocytopenia":[114],"thrombocytopenia":[116],"remarkable":[118],"took":[120],"a":[121,155],"long":[122],"time":[123],"to":[124,154,196],"recover.":[125],"The":[126],"above":[127],"results":[128],"suggested":[129,184],"that":[130,168,185],"most":[132],"effective":[133,165],"regimen":[134],"cancer":[139],"using":[140],"is":[144,194],"alone,":[146],"single":[148],"doses":[149],"50":[151],"mg":[152],"up":[153],"total":[156],"dose":[157],"150-200":[159],"mg.":[160],"Histological":[161],"examination":[162],"revealed":[167],"central":[170],"region":[171],"tumor":[174,192],"more":[176],"markedly":[177],"recrotic":[178],"periphery.":[181],"It":[182],"on":[191],"tissues":[193],"related":[195],"mechanism":[198],"anticancer":[200],"agents.":[201]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}