{"id":"https://openalex.org/W2407039720","doi":null,"title":"Interferon therapy does not prevent hepatocellular carcinoma in HCV compensated cirrhosis.","display_name":"Interferon therapy does not prevent hepatocellular carcinoma in HCV compensated cirrhosis.","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2407039720","mag":"2407039720","pmid":"https://pubmed.ncbi.nlm.nih.gov/12397752"},"language":"en","primary_location":{"id":"pmid:12397752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12397752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101699255","display_name":"Gianni Testino","orcid":"https://orcid.org/0000-0002-6737-0685","observed_orcids":["https://orcid.org/0000-0002-6737-0685","https://orcid.org/0000-0002-4208-3591"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianni Testino","raw_affiliation_strings":["Unit of Hepato-Gastroenterology, S. Martino Hospital, Italy. testinogia@tiscalinet.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Hepato-Gastroenterology, S. Martino Hospital, Italy. testinogia@tiscalinet.it","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035113511","display_name":"Filippo Ansaldi","orcid":"https://orcid.org/0009-0002-0099-9347","observed_orcids":["https://orcid.org/0009-0002-0099-9347"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Ansaldi","raw_affiliation_strings":["A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021552292","display_name":"Enzo Andorno","orcid":"https://orcid.org/0009-0001-3208-104X","observed_orcids":["https://orcid.org/0009-0001-3208-104X"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enzo Andorno","raw_affiliation_strings":["A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112301255","display_name":"Gian Luigi Ravetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian Luigi Ravetti","raw_affiliation_strings":["A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102303814","display_name":"Carlo Ferro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Ferro","raw_affiliation_strings":["Universita degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025959520","display_name":"Fabio De Iaco","orcid":"https://orcid.org/0009-0001-1155-4792","observed_orcids":["https://orcid.org/0009-0001-1155-4792"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio De Iaco","raw_affiliation_strings":["Universita degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008048480","display_name":"Giancarlo Icardi","orcid":"https://orcid.org/0000-0002-8463-8487","observed_orcids":["https://orcid.org/0000-0002-8463-8487"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Icardi","raw_affiliation_strings":["Universita degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054890023","display_name":"Umberto Valente","orcid":"https://orcid.org/0000-0002-1841-3802","observed_orcids":["https://orcid.org/0000-0002-1841-3802"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Valente","raw_affiliation_strings":["Universita degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2036,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.64935884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"49","issue":"48","first_page":"1636","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-therapy","display_name":"interferon therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9240000247955322},{"id":"https://openalex.org/keywords/compensated-cirrhosis","display_name":"compensated cirrhosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hcv-rna","display_name":"HCV RNA","score":0.8259999752044678},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.5509999990463257},{"id":"https://openalex.org/keywords/cirrhosis-progression","display_name":"cirrhosis progression","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.9108870029449463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8747559785842896},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7692425847053528},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6771129965782166},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.640920102596283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.625848650932312},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.5630337595939636},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.536575436592102},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.49715879559516907},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.42678651213645935},{"id":"https://openalex.org/C151678543","wikidata":"https://www.wikidata.org/wiki/Q3827867","display_name":"BDNA test","level":4,"score":0.4128822088241577},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.371578574180603},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3196799159049988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20288655161857605},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.18585368990898132}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12397752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12397752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unige.it:11567/247733","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/247733","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2407039720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12397752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2469228714","https://openalex.org/W2132933944","https://openalex.org/W2050737312","https://openalex.org/W7146194719","https://openalex.org/W1988964675","https://openalex.org/W7055934290","https://openalex.org/W2098193940","https://openalex.org/W2043892107","https://openalex.org/W2075365109","https://openalex.org/W2145142490"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Recent":[1],"experiences":[2],"suggest":[3],"that":[4],"interferon":[5,20,75,174,193,207,220,241,277],"may":[6],"significantly":[7],"decrease":[8],"the":[9,40,44,72,137,140,150,211,240,251,271,276],"incidence":[10,45],"of":[11,46,50,62,74,131,139,142,149,213,239,250,273],"hepatocellular":[12,47,132,214,265],"carcinoma.":[13,266],"We":[14,83],"conducted":[15],"a":[16,178,261],"randomized":[17],"study":[18],"with":[19,31,39,87,154,227],"versus":[21],"no":[22],"therapy":[23,76,185,278],"in":[24,216,225,268,282],"hepatitis":[25,88,106],"C":[26,89,100,107],"virus":[27,90,101,108],"Child":[28],"A":[29,60],"cirrhosis":[30,257],"abnormal":[32],"alanine":[33],"aminotransferase":[34],"and":[35,53,152,229],"HCV-RNA":[36,120],"positive":[37],"serum":[38],"aim":[41],"to":[42,70,243,270],"investigate":[43],"carcinoma,":[48],"worsening":[49,228,272],"cirrhosis's":[51,274],"stage":[52,275],"death":[54],"or":[55],"orthotopic":[56],"liver":[57,151,231],"transplantation.":[58],"METHODOLOGY:":[59],"cohort":[61],"122":[63],"patients":[64,86,167,222],"prospectively":[65],"followed":[66],"was":[67,103,122,134,164],"analyzed":[68],"retrospectively":[69],"assess":[71],"effect":[73],"(mean":[77,168,194],"follow-up:":[78],"96":[79],"+/-":[80,171,197],"18.3":[81],"months).":[82],"only":[84],"chose":[85],"infection":[91],"who":[92],"had":[93],"undergone":[94],"blood":[95],"transfusion":[96],"before":[97],"1980.":[98],"Hepatitis":[99],"serotype":[102],"determined":[104,123],"by":[105,124,259],"serotyping":[109],"1-6":[110],"assay":[111],"(Murex":[112],"Biothec":[113],"Limited":[114],"Temple":[115],"Hill,":[116],"Dartford,":[117],"Kent,":[118],"UK).":[119],"level":[121],"bDNA,":[125],"Chiron":[126],"Corporation":[127],"Emeryville,":[128],"CA.":[129],"Diagnosis":[130],"carcinoma":[133,215],"made":[135],"on":[136],"basis":[138],"appearance":[141],"local":[143],"lesions":[144],"at":[145],"periodic":[146],"ultrasound":[147],"examination":[148],"confirmed":[153],"spiral":[155],"computed":[156],"tomography.":[157],"Fine":[158],"needle":[159],"biopsy":[160],"under":[161],"sonographic":[162],"guidance":[163],"effected.":[165],"Fifty-nine":[166],"age:":[169,195],"55.3":[170],"7)":[172],"received":[173],"(3MU":[175],"three":[176],"times":[177],"week":[179],"for":[180,186,264],"12":[181],"months),":[182],"8":[183],"stopped":[184],"side":[187],"effects,":[188],"71":[189],"did":[190],"not":[191,209],"receive":[192],"56.8":[196],"8).":[198],"Baseline":[199],"characteristics":[200],"were":[201],"similar.":[202],"RESULTS:":[203],"It":[204],"emerges":[205],"how":[206],"does":[208],"reduce":[210],"risk":[212,262],"compensated":[217,283],"cirrhosis.":[218,284],"In":[219],"treated":[221],"an":[223],"improvement":[224],"relation":[226,269],"death/orthotopic":[230],"transplantation":[232],"has":[233],"been":[234],"noted.":[235],"CONCLUSIONS:":[236],"The":[237],"use":[238],"seems":[242],"be":[244,280],"scarcely":[245],"useful":[246,281],"when":[247],"structural":[248],"alterations":[249],"cirrhotic":[252],"kind":[253],"show":[254],"up,":[255],"as":[256],"represents":[258],"itself":[260],"factor":[263],"Nevertheless,":[267],"can":[279]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}