{"id":"https://openalex.org/W2407015992","doi":null,"title":"[Anticarcinogenic role of melatonin--potential mechanisms].","display_name":"[Anticarcinogenic role of melatonin--potential mechanisms].","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2407015992","mag":"2407015992","pmid":"https://pubmed.ncbi.nlm.nih.gov/21995112"},"language":"pl","primary_location":{"id":"pmid:21995112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21995112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medycyna pracy","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018561788","display_name":"Agnieszka Bukowska","orcid":"https://orcid.org/0000-0002-3223-6750","observed_orcids":["https://orcid.org/0000-0002-3223-6750"]},"institutions":[{"id":"https://openalex.org/I206105734","display_name":"Nofer Institute of Occupational Medicine","ror":"https://ror.org/02b5m3n83","country_code":"PL","type":"facility","lineage":["https://openalex.org/I206105734"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Agnieszka Bukowska","raw_affiliation_strings":["Zak\u0142ad Epidemiologii Srodowiskowej, Pracownia Epidemiologii Institut Medycyny Pracy im. prof. J. Nofera, \u0141\u00f3d\u017a. bukowska@imp.lodz.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zak\u0142ad Epidemiologii Srodowiskowej, Pracownia Epidemiologii Institut Medycyny Pracy im. prof. J. Nofera, \u0141\u00f3d\u017a. bukowska@imp.lodz.pl","institution_ids":["https://openalex.org/I206105734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018561788"],"corresponding_institution_ids":["https://openalex.org/I206105734"],"apc_list":null,"apc_paid":null,"fwci":1.1667,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.72707249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"62","issue":"4","first_page":"425","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/anticarcinogenic-activity","display_name":"anticarcinogenic activity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6290000081062317},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hormone-dependent-cancers","display_name":"hormone-dependent tumors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.7979999780654907},{"id":"https://openalex.org/keywords/pinealectomy","display_name":"pinealectomy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/carcinogens","display_name":"carcinogens","score":0.7649999856948853},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9765215516090393},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.7080482244491577},{"id":"https://openalex.org/C2776201020","wikidata":"https://www.wikidata.org/wiki/Q7195422","display_name":"Pinealectomy","level":4,"score":0.6862751841545105},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5419611930847168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5332642793655396},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5332177877426147},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5217017531394958},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.509510338306427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4628191888332367},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4494495093822479},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.4471408426761627},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.4148067235946655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35227012634277344},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33097463846206665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.163457989692688},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.1416456699371338},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:21995112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21995112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medycyna pracy","raw_type":"English Abstract"},{"id":"mag:2407015992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21995112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2412386364","doi":null,"is_oa":false,"landing_page_url":"http://cybra.p.lodz.pl/Content/8941/Medycyna_Pracy_2011_T_62_nr_4_(425-434).pdf","pdf_url":null,"source":{"id":"https://openalex.org/S64923111","display_name":"Medycyna Pracy","issn_l":"0465-5893","issn":["0465-5893","2353-1339"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317318","host_organization_name":"Nofer Institute of Occupational Medicine","host_organization_lineage":["https://openalex.org/P4310317318"],"host_organization_lineage_names":["Nofer Institute of Occupational Medicine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medycyna Pracy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W265456471","https://openalex.org/W270611766","https://openalex.org/W1481663693","https://openalex.org/W1500606150","https://openalex.org/W1557668836","https://openalex.org/W1573881090","https://openalex.org/W1596063300","https://openalex.org/W1836501822","https://openalex.org/W1881108429","https://openalex.org/W1972069681","https://openalex.org/W1975291167","https://openalex.org/W1978386536","https://openalex.org/W1979642701","https://openalex.org/W1980544171","https://openalex.org/W1985079131","https://openalex.org/W1985087876","https://openalex.org/W1985577941","https://openalex.org/W1986732480","https://openalex.org/W1988241394","https://openalex.org/W1988908275","https://openalex.org/W1994890751","https://openalex.org/W1998713395","https://openalex.org/W2002061397","https://openalex.org/W2005327805","https://openalex.org/W2013936099","https://openalex.org/W2015934269","https://openalex.org/W2026875500","https://openalex.org/W2027222274","https://openalex.org/W2028085265","https://openalex.org/W2029479550","https://openalex.org/W2038491937","https://openalex.org/W2040644496","https://openalex.org/W2045043453","https://openalex.org/W2045531839","https://openalex.org/W2049985521","https://openalex.org/W2050309531","https://openalex.org/W2051596977","https://openalex.org/W2053375677","https://openalex.org/W2053534737","https://openalex.org/W2055801190","https://openalex.org/W2055988844","https://openalex.org/W2058643553","https://openalex.org/W2058826220","https://openalex.org/W2069389572","https://openalex.org/W2085456997","https://openalex.org/W2088014624","https://openalex.org/W2090517643","https://openalex.org/W2094560884","https://openalex.org/W2098901841","https://openalex.org/W2103172237","https://openalex.org/W2113613331","https://openalex.org/W2126747014","https://openalex.org/W2142069774","https://openalex.org/W2144292389","https://openalex.org/W2146287748","https://openalex.org/W2153825511","https://openalex.org/W2155679235","https://openalex.org/W2158874366","https://openalex.org/W2160684230","https://openalex.org/W2164700186","https://openalex.org/W2165834747","https://openalex.org/W2172008556"],"related_works":["https://openalex.org/W2412386364","https://openalex.org/W2148895922","https://openalex.org/W2163976491","https://openalex.org/W3037357223","https://openalex.org/W4394062765","https://openalex.org/W45641394","https://openalex.org/W2883791115","https://openalex.org/W2156261924","https://openalex.org/W165592813","https://openalex.org/W1023444678"],"abstract_inverted_index":{"Over":[0],"50":[1],"years":[2],"have":[3,32,171],"passed":[4],"since":[5],"the":[6,11,51,68,72,79,105,125,144],"detection":[7],"of":[8,24,36,45,56,84,99,107,117,127,143,149,153,168,180],"melatonin":[9,16,94,118],"in":[10,78,86,89,132,137,163,174],"cattle":[12],"pineal":[13],"gland.":[14],"Initially":[15],"was":[17,48],"believed":[18],"to":[19,49,61,75,121,185],"be":[20,122],"only":[21,191],"a":[22,147],"regulator":[23],"physiological":[25],"circadian":[26],"rhythm":[27],"processes,":[28],"however,":[29],"further":[30],"studies":[31,91,145],"revealed":[33],"other":[34],"characteristics":[35],"this":[37,46],"hormone,":[38],"including":[39,177],"its":[40,62],"anticarcinogenic":[41,151],"activity.":[42,64,112,140],"The":[43,65,82,113,166],"aim":[44],"work":[47],"review":[50,66],"literature":[52],"on":[53],"biological":[54],"role":[55],"melatonin,":[57,154,181],"with":[58],"special":[59],"reference":[60],"oncostatic":[63,115],"covered":[67],"articles":[69],"published":[70],"from":[71],"early":[73],"1960's":[74],"2010,":[76],"collected":[77],"MEDLINE":[80],"database.":[81],"majority":[83,167],"experimental":[85,169,196],"vitro":[87],"and":[88,97,110,135],"vivo":[90],"suggest":[92],"that":[93],"inhibits":[95],"initiation":[96],"growth":[98],"hormone-dependent":[100],"tumors":[101],"by":[102],"decreasing":[103],"both":[104],"expression":[106],"estrogen":[108],"receptors":[109],"aromatase":[111],"protective":[114],"activity":[116],"is":[119,156],"likely":[120],"expressed":[123],"through":[124],"inhibition":[126],"cancer":[128],"cell":[129],"proliferation,":[130],"decrease":[131],"oxidative":[133],"stress":[134],"increase":[136],"immune":[138],"system":[139],"Although":[141],"most":[142],"confirm":[146],"hypothesis":[148],"an":[150],"effect":[152],"it":[155],"not":[157],"clear":[158],"whether":[159],"these":[160],"effects":[161],"occur":[162],"natural":[164],"conditions.":[165],"models":[170],"been":[172],"applied":[173],"extreme":[175],"conditions,":[176],"high":[178],"doses":[179],"pinealectomy":[182],"or":[183],"exposure":[184],"carcinogens.":[186],"To":[187],"date,":[188],"there":[189],"are":[190],"limited":[192],"epidemiological":[193],"data":[194],"supporting":[195],"observations.":[197]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}