{"id":"https://openalex.org/W2406996090","doi":null,"title":"[Intra-arterial administration of epirubicin in the treatment of non-resectable hepatocellular carcinoma. Epirubicin Study Group for Hepatocellular Carcinoma].","display_name":"[Intra-arterial administration of epirubicin in the treatment of non-resectable hepatocellular carcinoma. Epirubicin Study Group for Hepatocellular Carcinoma].","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W2406996090","mag":"2406996090","pmid":"https://pubmed.ncbi.nlm.nih.gov/3019251"},"language":"ja","primary_location":{"id":"pmid:3019251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3019251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030048967","display_name":"Naofumi Nagasue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Nagasue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108594896","display_name":"Hirofumi YUKAYA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Yukaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068265502","display_name":"J Okamura","orcid":"https://orcid.org/0000-0003-0389-2051","observed_orcids":["https://orcid.org/0000-0003-0389-2051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Okamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110107499","display_name":"C Kuroda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Kuroda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Kubo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Kubo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Hirai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Hirai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113770723","display_name":"Kyuichi Tanikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tanikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006889095","display_name":"Kenji Okita","orcid":"https://orcid.org/0000-0003-0254-4020","observed_orcids":["https://orcid.org/0000-0003-0254-4020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Okita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013897530","display_name":"Kazusaburo Ando","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025923948","display_name":"Kei Tamura","orcid":"https://orcid.org/0000-0002-6077-5428","observed_orcids":["https://orcid.org/0000-0002-6077-5428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"9","first_page":"2786","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/intra-arterial-chemotherapy","display_name":"intra-arterial chemotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion","display_name":"hepatic artery infusion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/unresectable-liver-cancer","display_name":"unresectable liver cancer","score":0.9240000247955322},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/doxorubicin-comparison","display_name":"doxorubicin comparison","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-response-rate","display_name":"tumor response rate","score":0.7080000042915344},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9480000138282776},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.9834586381912231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8865060806274414},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8470195531845093},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6931168437004089},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6040880680084229},{"id":"https://openalex.org/C2776581026","wikidata":"https://www.wikidata.org/wiki/Q864868","display_name":"Bone marrow suppression","level":3,"score":0.5567523837089539},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.553366482257843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5380522608757019},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46232321858406067},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4454032778739929},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3354617953300476},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3019251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3019251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},{"id":"mag:2406996090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3019251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2478040519","https://openalex.org/W2046801195","https://openalex.org/W2009435220","https://openalex.org/W2065281115","https://openalex.org/W2440500325","https://openalex.org/W2398592440","https://openalex.org/W2442450821","https://openalex.org/W2070923720","https://openalex.org/W2074965477","https://openalex.org/W1994513787"],"abstract_inverted_index":{"A":[0,162],"group":[1],"study":[2,194],"was":[3,65,91,117,153],"conducted":[4],"to":[5,42,75,86,125,220],"investigate":[6],"the":[7,16,27,45,56,71,111,132,156,166,204,212,215,224],"effect":[8],"of":[9,13,18,55,62,83,140,165,177,189,206,211,226],"intra-hepatic":[10],"arterial":[11],"administration":[12,176],"epirubicin":[14,181,197,227],"in":[15,94,159,187,203],"treatment":[17,205],"non-resectable":[19],"hepatocellular":[20],"carcinoma(HCC).":[21],"Sixty-four":[22],"patients":[23,51,120,172],"were":[24,30,98,143],"entered":[25],"into":[26,70],"study.":[28,161,235],"There":[29,97],"51":[31],"males":[32],"and":[33,107,149,214],"13":[34],"females,":[35],"with":[36,169,228],"an":[37,81],"age":[38],"range":[39],"from":[40],"32":[41],"79":[43],"years,":[44],"average":[46],"being":[47],"59.1":[48],"years.":[49],"Fifty-four":[50],"had":[52],"associated":[53],"cirrhosis":[54],"liver.":[57],"Epirubicin":[58],"at":[59,80,155],"a":[60,68,200],"dose":[61],"60-90":[63],"mg/m2":[64],"infused":[66],"as":[67],"bolus":[69],"hepatic":[72],"artery":[73],"1":[74,99],"4":[76],"times":[77],"(average":[78],"1.8)":[79],"interval":[82,216],"3":[84,87],"weeks":[85],"months.":[88],"Tumor":[89],"size":[90],"properly":[92],"evaluated":[93],"53":[95],"patients.":[96],"CR,":[100],"7":[101,103],"PR,":[102],"MR,":[104],"27":[105],"NC,":[106],"11":[108],"PD.":[109],"Thus,":[110],"response":[112],"rate":[113],"(CR":[114],"+":[115],"PR)":[116],"15.1%.":[118],"Seventeen":[119],"are":[121,219],"still":[122],"alive":[123],"305":[124],"720":[126],"days":[127],"(mean":[128],"505":[129],"days)":[130],"after":[131],"initial":[133],"treatment.":[134],"The":[135,192,208],"most":[136],"common":[137],"side":[138],"effects":[139],"this":[141,160],"drug":[142,213],"bone":[144],"marrow":[145],"suppression,":[146],"gastrointestinal":[147],"complaints,":[148],"alopecia.":[150],"Cardiac":[151],"toxicity":[152],"negligible":[154],"doses":[157],"used":[158],"retrospective":[163],"comparison":[164],"present":[167],"results":[168],"those":[170],"for":[171,217,234],"treated":[173],"by":[174],"intra-arterial":[175],"doxorubicin":[178,186],"demonstrated":[179],"that":[180,196],"is":[182,232],"more":[183],"effective":[184],"than":[185],"terms":[188],"survival":[190],"rate.":[191],"current":[193],"indicates":[195],"may":[198],"be":[199,221],"promising":[201],"alternative":[202],"HCC.":[207],"appropriate":[209],"dosage":[210],"infusion":[218],"elucidated.":[222],"Also,":[223],"combination":[225],"other":[229],"cytostatic":[230],"drugs":[231],"open":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}