{"id":"https://openalex.org/W2406445505","doi":null,"title":"Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.","display_name":"Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W2406445505","mag":"2406445505","pmid":"https://pubmed.ncbi.nlm.nih.gov/1726835"},"language":"en","primary_location":{"id":"pmid:1726835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1726835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth regulation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054497725","display_name":"Subburaman Mohan","orcid":"https://orcid.org/0000-0003-0063-986X","observed_orcids":["https://orcid.org/0000-0003-0063-986X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Mohan","raw_affiliation_strings":["Dept of Biochemistry, Loma Linda University, CA","Department of Biochemistry, Loma Linda University, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biochemistry, Loma Linda University, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Biochemistry, Loma Linda University, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033217982","display_name":"Baylink Dj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Baylink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3649,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.8079682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"1","issue":"3","first_page":"110","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.8709999918937683},{"id":"https://openalex.org/keywords/igf-binding-protein-4","display_name":"IGF binding protein-4","score":0.7559999823570251},{"id":"https://openalex.org/keywords/bone-cell-proliferation","display_name":"bone cell proliferation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6809999942779541},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.8069999814033508},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/3-isobutyl-1-methylxanthine","display_name":"3-isobutyl-1-methylxanthine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/osteosarcoma-cells","display_name":"osteosarcoma cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/autocrine-and-paracrine-regulation","display_name":"autocrine and paracrine regulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bone-cells","display_name":"bone cells","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7705082893371582},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.7563306093215942},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6943316459655762},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5562562346458435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5369906425476074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5293641090393066},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5031978487968445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49489516019821167},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.4875723719596863},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.4859088957309723},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.4251338839530945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3863487243652344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3397829234600067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.263774037361145},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17496588826179504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08890610933303833},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.07726031541824341}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018974","descriptor_name":"Insulin-Like Growth Factor Binding Protein 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1726835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1726835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth regulation","raw_type":"Journal Article"},{"id":"mag:2406445505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1726835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2494010510","display_name":"Endosteal Bone Volume Regulation and Osteoporosis","funder_award_id":"R01AR031062","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1964874419","https://openalex.org/W1994470495","https://openalex.org/W2037659124","https://openalex.org/W1511750039","https://openalex.org/W7051655019","https://openalex.org/W2397261717","https://openalex.org/W2018179997","https://openalex.org/W1991780769","https://openalex.org/W2476805144","https://openalex.org/W2017530941"],"abstract_inverted_index":{"Our":[0],"previous":[1],"studies":[2,57,138],"have":[3],"shown":[4],"that":[5,44,81,122,154,169],"insulin-like":[6],"growth":[7],"factor-II":[8],"(IGF-II)":[9],"is":[10,40],"an":[11,126,132],"important":[12],"autocrine/paracrine":[13],"regulator":[14],"of":[15,30,48,54,58,82,95,131,144,170,225],"human":[16,34,64,85,182],"bone":[17,35,86,183,208],"cell":[18,150,209,240],"proliferation.":[19,210],"In":[20,88,211],"this":[21,89],"study,":[22,90],"we":[23,61,91],"sought":[24],"to":[25,80,163,168],"look":[26],"at":[27,50],"the":[28,46,93,115,129,140,155,223],"regulation":[29],"IGF-II":[31,38,49,59,116,206],"production":[32,130,224],"by":[33,158],"cells":[36,66,73,160,184],"since":[37,71],"synthesis":[39],"a":[41,51,68,218,243],"key":[42],"variable":[43],"regulates":[45],"actions":[47,202],"local":[52],"site":[53],"bone.":[55],"For":[56],"regulation,":[60],"used":[62],"TE85":[63,135,149,159,239],"osteosarcoma":[65],"as":[67,177],"model":[69],"system":[70],"these":[72,123,229],"exhibited":[74],"several":[75],"characteristics":[76],"which":[77,97,234],"are":[78],"similar":[79],"untransformed":[83],"normal":[84],"cells.":[87,136],"investigated":[92],"effects":[94],"agents":[96,124,233],"increase":[98,127,235],"intracellular":[99,236],"cAMP":[100,237],"(forskolin,":[101],"isobutylmethyl":[102],"xanthine":[103],"and":[104,107,142,199,205,214,232],"prostaglandin":[105],"E2)":[106],"N6,O2'":[108],"dibutyryl":[109],"adenosine":[110],"3',5'-cyclic":[111],"monophosphate":[112],"(DBcAMP)":[113],"on":[114,139,203],"regulatory":[117],"system.":[118],"It":[119],"was":[120,166],"found":[121],"caused":[125,217],"in":[128,134,161,222,242],"IGFBP":[133,145,156,174],"Subsequent":[137],"purification":[141],"characterization":[143],"from":[146,180],"DBcAMP":[147,164,215,231],"treated":[148],"conditioned":[151],"medium":[152],"revealed":[153],"produced":[157],"response":[162],"treatment":[165],"identical":[167],"25":[171],"kDa":[172],"inhibitory":[173,201],"(now":[175],"designated":[176],"IGFBP-4)":[178],"purified":[179],"TE89":[181],"based":[185],"on:":[186],"1)":[187],"N-terminal":[188],"amino":[189,193],"acid":[190,194],"sequence,":[191],"2)":[192],"composition,":[195],"3)":[196],"molecular":[197],"weight":[198],"4)":[200],"basal":[204],"induced":[207],"addition,":[212],"forskolin":[213],"also":[216],"dose":[219,244],"dependent":[220,245],"decrease":[221],"IGF-II.":[226],"Consistent":[227],"with":[228],"results,":[230],"inhibited":[238],"proliferation":[241],"manner.(ABSTRACT":[246],"TRUNCATED":[247],"AT":[248],"250":[249],"WORDS)":[250]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}