{"id":"https://openalex.org/W2406363109","doi":null,"title":"USE OF THE HYPOXIA-INDUCED POLYCYTHEMIC MOUSE IN THE ASSAY AND STANDARDIZATION OF ERYTHROPOIETIN.","display_name":"USE OF THE HYPOXIA-INDUCED POLYCYTHEMIC MOUSE IN THE ASSAY AND STANDARDIZATION OF ERYTHROPOIETIN.","publication_year":1963,"publication_date":"1963-11-01","ids":{"openalex":"https://openalex.org/W2406363109","mag":"2406363109","pmid":"https://pubmed.ncbi.nlm.nih.gov/14078010"},"language":"en","primary_location":{"id":"pmid:14078010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14078010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067126291","display_name":"Arthur H. Weintraub","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H WEINTRAUB","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111752136","display_name":"Albert Saul Gordon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S GORDON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085506284","display_name":"James F. Camiscoli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F CAMISCOLI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.0549,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.98073004,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":null,"first_page":"743","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parallel-line-assay","display_name":"parallel line assay","score":0.47600001096725464},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.9422961473464966},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.7745095491409302},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.578791618347168},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4776434004306793},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.47475293278694153},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.459267258644104},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.4493480324745178},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41937577724456787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4123450517654419},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.41220200061798096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37958768010139465},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.3709118664264679},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3410447835922241},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3342837691307068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3307284712791443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3158954977989197},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28502824902534485},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.2071838676929474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19339615106582642},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068817","descriptor_name":"Epoetin Alfa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011086","descriptor_name":"Polycythemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14078010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14078010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2406363109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14078010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2056635665","https://openalex.org/W2065192041","https://openalex.org/W2262926579","https://openalex.org/W2409639791","https://openalex.org/W2416599184"],"related_works":["https://openalex.org/W1897113920","https://openalex.org/W2419510480","https://openalex.org/W2408595728","https://openalex.org/W2905275120","https://openalex.org/W2063736691","https://openalex.org/W2086153233","https://openalex.org/W4231544622","https://openalex.org/W2407676364","https://openalex.org/W2198342443","https://openalex.org/W1547874759"],"abstract_inverted_index":{"Abstract":[0],"The":[2,155],"polycythemic":[3],"mouse,":[4],"produced":[5],"by":[6,88],"the":[7,23,38,64,83,89,92,136,140,143,189],"method":[8],"of":[9,25,28,40,49,63,85,91,99,122,142,153,158,161],"discontinuous":[10],"hypoxia,":[11],"has":[12],"been":[13],"shown":[14],"to":[15,31,119,130,181,184],"be":[16],"a":[17,78,100,159],"highly":[18],"sensitise":[19],"test":[20],"animal":[21],"for":[22,37,82,128,148],"assay":[24,69],"erythropoietin.":[26],"Exposure":[27],"such.":[29],"mice":[30],"0.4":[32],"atmosphere":[33],"is":[34],"more":[35,59],"efficient":[36],"production":[39],"suitable":[41],"plethoric":[42],"animals":[43],"than":[44],"0.5":[45],"atmosphere;":[46],"lower":[47,65],"baselines":[48],"red":[50],"blood":[51],"cell":[52],"Fe":[53],"59":[54],"incorporation":[56],"are":[57],"attained":[58],"rapidly":[60],"after":[61],"interruption":[62],"pressure.":[66],"With":[67],"this":[68,146],"method,":[70],"Erythropoictin":[71],"Standard":[72],"B":[73],"(ESA)":[74],"was":[75,165],"evaluated":[76],"as":[77],"primary":[79],"reference":[80],"standard":[81,104],"expression":[84],"unknown":[86],"potencies":[87],"use":[90],"4":[93,185],"point":[94,186],"parallel-line":[95],"procedure.":[96],"Periodic":[97],"calibration":[98],"purified":[101],"sheep-crythropoietin":[102],"laboratory":[103],"with":[105,176,188],"ESA":[106],"showed":[107],"good":[108],"reproducibility":[109],"in":[110,125,145],"slope,":[111],"and":[112,115,171],"precision":[113],"characteristics,":[114],"potency":[116,137],"ratios":[117],"close":[118],"1.":[120],"Incubation":[121],"sheep":[123,190],"erythropoietin":[124],"dog":[126],"plasma":[127,172],"up":[129],"5":[131],"hours":[132],"did":[133],"not":[134],"affect":[135],"estimate,":[138],"indicating":[139],"stability":[141],"factor":[144],"medium":[147],"at":[149],"least":[150],"that":[151],"length":[152],"time.":[154],"dose/response":[156],"relation":[157],"number":[160],"human":[162],"crythropoietin":[163],"preparations":[164],"also":[166],"studied.":[167],"Several":[168],"crude":[169],"urine":[170],"samples":[173],"from":[174],"patients":[175],"Cooley's":[177],"anemia":[178],"were":[179],"found":[180],"be,":[182],"amenable":[183],"analysis":[187],"standard.":[191]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}